Tubular duplication of the colon is very rare especially in adulthood,because it is frequently symptomatic earlier in newborn life,so only few cases are reported in literature.Several theories are proposed to explain ...Tubular duplication of the colon is very rare especially in adulthood,because it is frequently symptomatic earlier in newborn life,so only few cases are reported in literature.Several theories are proposed to explain the onset and the evolution of gut malformations as the aberrant lumen recanalization or the diverticular theory,the alteration of the lateral closure of the embryonal disk or finally the dorsal protrusion of the yolksac for herniation or adhesion to the ectoderm for an abnormality of the longitudinal line,but none clarifies the exact genesis of duplication.We present a case of "Y-shaped" tubular duplication of the transverse colon in a 21-year-old adult,with a history of chronic pain and constipation,referred to our department for abdominal pain with retrosternal irradiation,treated with the resection of the aberrant bowel.展开更多
Fibrin-based hydrogels have been widely used in various tissue engineering because of their biocompatibility,biodegradability,tunable mechanical characteristics and nanofibrous structural properties.However,their abil...Fibrin-based hydrogels have been widely used in various tissue engineering because of their biocompatibility,biodegradability,tunable mechanical characteristics and nanofibrous structural properties.However,their ability to support stem cells for hair follicle neogenesis is unclear.In this study,we investigated the effect of fibrin hydrogels in supporting skin-derived precursors(SKPs)in hair follicle neogenesis.Our results showed that SKPs in fibrin hydrogels with high cell viability and proliferation,the stemness of SKPs could be maintained,and the expression of hair induction signature genes such as akp2 and nestin was enhanced.Moreover,hair follicle reconstruction experiments showed de novo hair genesis in mice and the hairs persisted for a long time without teratoma formation.More importantly,the blood vessels and sebaceous glands were also regenerated.Our study demonstrated that fibrin hydrogels are promising in hair follicle regeneration and have potential application in clinical settings for alopecia and wound healing.展开更多
【目的】探讨多普勒超声监测不同剂量酚妥拉明对新生儿重症肺炎伴肺动脉高压疗效的意义,为临床使用酚妥拉明辅佐治疗重症肺炎、防止并发心力衰竭提供依据。【方法】连续监测22例重症肺炎患儿生命体征的变化,分别于应用酚妥拉明前及不同...【目的】探讨多普勒超声监测不同剂量酚妥拉明对新生儿重症肺炎伴肺动脉高压疗效的意义,为临床使用酚妥拉明辅佐治疗重症肺炎、防止并发心力衰竭提供依据。【方法】连续监测22例重症肺炎患儿生命体征的变化,分别于应用酚妥拉明前及不同用药剂量时,经彩色多普勒超声测定左心室射血分数(ejection fraction,EF),左心室短轴缩短率(shortening fraction,FS),二尖瓣口血流频谱E峰、A峰值流速(maximal mitral velocity in early and late diastole,EV、AV)以及肺动脉压力(pulmonary arterial pressure,PAP)的变化。【结果】不同剂量酚妥拉明静滴时,重症肺炎患儿肺动脉压力以及射血分数改变差异有显著性,当以5 g/(kg.min)速度静滴酚妥拉明时,PAP显著下降,当进一步加大剂量至10μg/(kg.min)时,PAP进一步下降,同时体循环压力也出现明显的下降,心率加快。MVA/E比值随剂量增加呈下降趋势,但差异无显著性。且酚妥拉明剂量增加至10μg/(kg.min)时,2例患儿出现明显鼻塞。【结论】静脉应用酚妥拉明对重型肺炎伴肺动脉高压患儿有良好的血流动力学效应,相对选择性扩张肺血管,同时减轻心脏的前后负荷,宜从小剂量开始,最适剂量为5 g/(kg.min)。展开更多
Combined treatment of ischemic stroke with Chinese medicine and exogenous bone marrow mesenchymal stem cell(BMSC) transplantation may improve the removal of blood stasis and stimulation of neogenesis.Chinese medicines...Combined treatment of ischemic stroke with Chinese medicine and exogenous bone marrow mesenchymal stem cell(BMSC) transplantation may improve the removal of blood stasis and stimulation of neogenesis.Chinese medicines that remove blood stasis not only promote blood circulation but also calm the endopathic wind,remove heat,resolve phlegm,remove toxic substances and strengthen body resistance.The medicinal targeting effect of Chinese medicine can promote the homing of BMSCs,and the synergistic therapeutic effects of drugs can contribute to BMSC differentiation.As such,exogenous BMSC transplantation has potential advantages for neogenesis.Chinese medicines and exogenous BMSCs provide complementary functions for the removal of blood stasis and stimulation of neogenesis.Therefore,a combination of Chinese medicine and transplantation of exogenous BMSCs may be particularly suited to ischemic stroke treatment.展开更多
文摘Tubular duplication of the colon is very rare especially in adulthood,because it is frequently symptomatic earlier in newborn life,so only few cases are reported in literature.Several theories are proposed to explain the onset and the evolution of gut malformations as the aberrant lumen recanalization or the diverticular theory,the alteration of the lateral closure of the embryonal disk or finally the dorsal protrusion of the yolksac for herniation or adhesion to the ectoderm for an abnormality of the longitudinal line,but none clarifies the exact genesis of duplication.We present a case of "Y-shaped" tubular duplication of the transverse colon in a 21-year-old adult,with a history of chronic pain and constipation,referred to our department for abdominal pain with retrosternal irradiation,treated with the resection of the aberrant bowel.
基金supported by National Natural Science Foundation of China(32000956)the Science and Technology Innovation Program of Hunan Province(2020RC4023).
文摘Fibrin-based hydrogels have been widely used in various tissue engineering because of their biocompatibility,biodegradability,tunable mechanical characteristics and nanofibrous structural properties.However,their ability to support stem cells for hair follicle neogenesis is unclear.In this study,we investigated the effect of fibrin hydrogels in supporting skin-derived precursors(SKPs)in hair follicle neogenesis.Our results showed that SKPs in fibrin hydrogels with high cell viability and proliferation,the stemness of SKPs could be maintained,and the expression of hair induction signature genes such as akp2 and nestin was enhanced.Moreover,hair follicle reconstruction experiments showed de novo hair genesis in mice and the hairs persisted for a long time without teratoma formation.More importantly,the blood vessels and sebaceous glands were also regenerated.Our study demonstrated that fibrin hydrogels are promising in hair follicle regeneration and have potential application in clinical settings for alopecia and wound healing.
文摘【目的】探讨多普勒超声监测不同剂量酚妥拉明对新生儿重症肺炎伴肺动脉高压疗效的意义,为临床使用酚妥拉明辅佐治疗重症肺炎、防止并发心力衰竭提供依据。【方法】连续监测22例重症肺炎患儿生命体征的变化,分别于应用酚妥拉明前及不同用药剂量时,经彩色多普勒超声测定左心室射血分数(ejection fraction,EF),左心室短轴缩短率(shortening fraction,FS),二尖瓣口血流频谱E峰、A峰值流速(maximal mitral velocity in early and late diastole,EV、AV)以及肺动脉压力(pulmonary arterial pressure,PAP)的变化。【结果】不同剂量酚妥拉明静滴时,重症肺炎患儿肺动脉压力以及射血分数改变差异有显著性,当以5 g/(kg.min)速度静滴酚妥拉明时,PAP显著下降,当进一步加大剂量至10μg/(kg.min)时,PAP进一步下降,同时体循环压力也出现明显的下降,心率加快。MVA/E比值随剂量增加呈下降趋势,但差异无显著性。且酚妥拉明剂量增加至10μg/(kg.min)时,2例患儿出现明显鼻塞。【结论】静脉应用酚妥拉明对重型肺炎伴肺动脉高压患儿有良好的血流动力学效应,相对选择性扩张肺血管,同时减轻心脏的前后负荷,宜从小剂量开始,最适剂量为5 g/(kg.min)。
基金Supported by The Science and Technology Development Fund of Macao Special Administrative Region(No.048/2008/ A3)
文摘Combined treatment of ischemic stroke with Chinese medicine and exogenous bone marrow mesenchymal stem cell(BMSC) transplantation may improve the removal of blood stasis and stimulation of neogenesis.Chinese medicines that remove blood stasis not only promote blood circulation but also calm the endopathic wind,remove heat,resolve phlegm,remove toxic substances and strengthen body resistance.The medicinal targeting effect of Chinese medicine can promote the homing of BMSCs,and the synergistic therapeutic effects of drugs can contribute to BMSC differentiation.As such,exogenous BMSC transplantation has potential advantages for neogenesis.Chinese medicines and exogenous BMSCs provide complementary functions for the removal of blood stasis and stimulation of neogenesis.Therefore,a combination of Chinese medicine and transplantation of exogenous BMSCs may be particularly suited to ischemic stroke treatment.
基金This work is partly supported by the French CNRS/SPI (programATIP,programIMPRES) ,the Region of Lorraine ,France ,andthe Associa-tion Franco-Chinoise pour la Recherche Scientifique et Technique (PRAB03-06)
