Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modu...Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modulation of heart rate and neuronal excitability.Different from typical voltage-gated sodium channels and potassium channels,HCN channels were evoked inward currents when the cell was hyperpolarized.More and more recent studies have disclosed that HCN channels play important roles in the nervous system,which were linked with its special electrophysiological features as well as its regulatory effect on the cellular membrane excitability.HCN channels could be modulated by many factors including both extracellular molecules and intracellular signaling cascades,which made its functions complicated in the different condition.Based on its role,HCN channels are presumed to be a promising target for chronic pain and brain disorders.In this paper,we will focus on the advancement of roles of HCN channels in the neural system as well as its complex modulator factors.展开更多
Eight-port optical routers are widely used in cluster-mesh photonic networks-on-chip(No C). By using 24 groups of cross-coupling two-ring resonators, a 1-stage 8-port polymer optical router is proposed, which can opti...Eight-port optical routers are widely used in cluster-mesh photonic networks-on-chip(No C). By using 24 groups of cross-coupling two-ring resonators, a 1-stage 8-port polymer optical router is proposed, which can optically route 7 channel wavelength data streams along definite path in two-dimensional(2D) plane. Under the selected 7 channel wavelengths, the insertion losses along all routing paths are within 0.02-0.58 d B, the maximum crosstalk of all routing operations is less than-39 d B, and the device footprint size is about 0.79 mm2. Then, a universal novel structure and routing scheme of N-stage cascaded 8-port optical router are presented, which contains 7N channel wavelengths. Because of the good scalability in wavelength, this device shows potential application of wideband signal routing in optical No C.展开更多
针对传统N通道滤波器存在增益以及时钟的偶次谐波对滤波性能产生不利影响的问题,利用增益提高技术和差分时钟技术提出了一种增益提高型、时钟偶次谐波消除的N通道带通滤波器。在TSMC 90 nm工艺参数和1.2 V电源电压下对其进行Spectre模...针对传统N通道滤波器存在增益以及时钟的偶次谐波对滤波性能产生不利影响的问题,利用增益提高技术和差分时钟技术提出了一种增益提高型、时钟偶次谐波消除的N通道带通滤波器。在TSMC 90 nm工艺参数和1.2 V电源电压下对其进行Spectre模拟。结果表明,滤波器的增益高于9.8 d B,中心频率可调范围为0.2~2.2 GHz,S11>10 d B,IIP3>11 d B,阻带抑制为26 d B。电路结构简单,仅由反向器、开关和电容组成,且易于集成。展开更多
基金supported by the Beijing Municipal Natural Science Foundation(7142123)
文摘Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modulation of heart rate and neuronal excitability.Different from typical voltage-gated sodium channels and potassium channels,HCN channels were evoked inward currents when the cell was hyperpolarized.More and more recent studies have disclosed that HCN channels play important roles in the nervous system,which were linked with its special electrophysiological features as well as its regulatory effect on the cellular membrane excitability.HCN channels could be modulated by many factors including both extracellular molecules and intracellular signaling cascades,which made its functions complicated in the different condition.Based on its role,HCN channels are presumed to be a promising target for chronic pain and brain disorders.In this paper,we will focus on the advancement of roles of HCN channels in the neural system as well as its complex modulator factors.
基金supported by the National Natural Science Foundation of China(Nos.61107021,61177027 and 61077041)the Ministry of Education of China(Nos.20110061120052 and 20120061130008)+2 种基金the China Postdoctoral Science Foundation Funded Project(Nos.20110491299 and 2012T50297)the Science and Technology Department of Jilin Province of China(No.20130522161JH)the Special Funds of Basic Science and Technology of Jilin University(No.201103076)
文摘Eight-port optical routers are widely used in cluster-mesh photonic networks-on-chip(No C). By using 24 groups of cross-coupling two-ring resonators, a 1-stage 8-port polymer optical router is proposed, which can optically route 7 channel wavelength data streams along definite path in two-dimensional(2D) plane. Under the selected 7 channel wavelengths, the insertion losses along all routing paths are within 0.02-0.58 d B, the maximum crosstalk of all routing operations is less than-39 d B, and the device footprint size is about 0.79 mm2. Then, a universal novel structure and routing scheme of N-stage cascaded 8-port optical router are presented, which contains 7N channel wavelengths. Because of the good scalability in wavelength, this device shows potential application of wideband signal routing in optical No C.
文摘针对传统N通道滤波器存在增益以及时钟的偶次谐波对滤波性能产生不利影响的问题,利用增益提高技术和差分时钟技术提出了一种增益提高型、时钟偶次谐波消除的N通道带通滤波器。在TSMC 90 nm工艺参数和1.2 V电源电压下对其进行Spectre模拟。结果表明,滤波器的增益高于9.8 d B,中心频率可调范围为0.2~2.2 GHz,S11>10 d B,IIP3>11 d B,阻带抑制为26 d B。电路结构简单,仅由反向器、开关和电容组成,且易于集成。
