目的探讨支气管哮喘患者乙酰甲胆碱Dmin与红细胞分布宽度(red cell distribution width, RDW)的相关性。方法支气管哮喘患者50例(哮喘组),同期体检健康者50例(对照组),检测2组血清RDW值;对哮喘组行支气管激发试验,记录乙酰甲胆碱Dmin;Pe...目的探讨支气管哮喘患者乙酰甲胆碱Dmin与红细胞分布宽度(red cell distribution width, RDW)的相关性。方法支气管哮喘患者50例(哮喘组),同期体检健康者50例(对照组),检测2组血清RDW值;对哮喘组行支气管激发试验,记录乙酰甲胆碱Dmin;Pearson相关法分析哮喘患者乙酰甲胆碱Dmin与RDW的相关性。结果哮喘组支气管激发试验强阳性17例,阳性17例,弱阳性16例;哮喘组强阳性、阳性、弱阳性者乙酰甲胆碱Dmin值[(2.88±1.47)、(8.01±0.90)、(15.52±3.74)u]依次升高(P<0.05);哮喘组强阳性者RDW[(13.86±0.76)%]高于阳性者[(13.16±1.15)%]、弱阳性者[(12.49±0.54)%]和对照组[(12.28±0.71)%](P<0.05),阳性者高于弱阳性者和对照组(P<0.05),弱阳性者与对照组比较差异无统计学意义(P>0.05);哮喘组强阳性、阳性、弱阳性者乙酰甲胆碱Dmin值与RDW均呈负相关(r=-0.901,P<0.001;r=-0.888,P<0.001;r=-0.649,P<0.001)。结论支气管哮喘患者乙酰甲胆碱Dmin值越低RDW越高,测定RDW可评估支气管哮喘患者的病情严重程度。展开更多
Bronchial hyperresponsiveness(BHR) is an important but not asthma-specific characteristic and can be assessed by direct and indirect methods, based on the stimulus causing airway obstruction. BHR has been proposed as ...Bronchial hyperresponsiveness(BHR) is an important but not asthma-specific characteristic and can be assessed by direct and indirect methods, based on the stimulus causing airway obstruction. BHR has been proposed as a prognostic marker of asthma severity and persistence, and may also be used to control pharmacological management of asthma. The most recent data on the prevalence and development of BHR in childhood and its predictive value for subsequent asthma development in late adolescence and adulthood is discussed in this review. According to the BHR-related scientific articles written in the English language and indexed in the publicly searchable PubM ed database, the prevalence of BHR varies based upon the methods used to assess it and the population examined. In general, however, BHR prevalence is reduced as children grow older, in both healthy and asthmatic populations. While asthma can be predicted by BHR, the predictive value is limited. Reduced lung function, allergic sensitization, female sex, and early respiratory illness have been identified as risk factors for BHR. The collective studies further indicate that BHR is a dynamic feature related to asthma, but asymptomatic BHR is also common. Ultimately, the prevalence of BHR varies depending on the population, the environment, and the evaluation methods used. While both the methacholine challenge and the exercise test may predict asthma in adolescence or early adulthood, the predictive value is higher for the methacholine challenge compared to the exercise test. The collective data presented in the present study demonstrate how BHR develops through childhood and its relation to bronchial asthma.展开更多
文摘目的探讨支气管哮喘患者乙酰甲胆碱Dmin与红细胞分布宽度(red cell distribution width, RDW)的相关性。方法支气管哮喘患者50例(哮喘组),同期体检健康者50例(对照组),检测2组血清RDW值;对哮喘组行支气管激发试验,记录乙酰甲胆碱Dmin;Pearson相关法分析哮喘患者乙酰甲胆碱Dmin与RDW的相关性。结果哮喘组支气管激发试验强阳性17例,阳性17例,弱阳性16例;哮喘组强阳性、阳性、弱阳性者乙酰甲胆碱Dmin值[(2.88±1.47)、(8.01±0.90)、(15.52±3.74)u]依次升高(P<0.05);哮喘组强阳性者RDW[(13.86±0.76)%]高于阳性者[(13.16±1.15)%]、弱阳性者[(12.49±0.54)%]和对照组[(12.28±0.71)%](P<0.05),阳性者高于弱阳性者和对照组(P<0.05),弱阳性者与对照组比较差异无统计学意义(P>0.05);哮喘组强阳性、阳性、弱阳性者乙酰甲胆碱Dmin值与RDW均呈负相关(r=-0.901,P<0.001;r=-0.888,P<0.001;r=-0.649,P<0.001)。结论支气管哮喘患者乙酰甲胆碱Dmin值越低RDW越高,测定RDW可评估支气管哮喘患者的病情严重程度。
文摘Bronchial hyperresponsiveness(BHR) is an important but not asthma-specific characteristic and can be assessed by direct and indirect methods, based on the stimulus causing airway obstruction. BHR has been proposed as a prognostic marker of asthma severity and persistence, and may also be used to control pharmacological management of asthma. The most recent data on the prevalence and development of BHR in childhood and its predictive value for subsequent asthma development in late adolescence and adulthood is discussed in this review. According to the BHR-related scientific articles written in the English language and indexed in the publicly searchable PubM ed database, the prevalence of BHR varies based upon the methods used to assess it and the population examined. In general, however, BHR prevalence is reduced as children grow older, in both healthy and asthmatic populations. While asthma can be predicted by BHR, the predictive value is limited. Reduced lung function, allergic sensitization, female sex, and early respiratory illness have been identified as risk factors for BHR. The collective studies further indicate that BHR is a dynamic feature related to asthma, but asymptomatic BHR is also common. Ultimately, the prevalence of BHR varies depending on the population, the environment, and the evaluation methods used. While both the methacholine challenge and the exercise test may predict asthma in adolescence or early adulthood, the predictive value is higher for the methacholine challenge compared to the exercise test. The collective data presented in the present study demonstrate how BHR develops through childhood and its relation to bronchial asthma.
