In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin secretion.Despite numerous in vitro and pre-clinical studies supporting the invol...In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin secretion.Despite numerous in vitro and pre-clinical studies supporting the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of diabetes and its complications,efforts to target mitochondria for glycemic control in diabetes using mitochondria-targeted antioxidants have produced inconsistent results.The intricate functionality of mitochondria is summarized to underscore the challenges it poses as a therapeutic target.While mitochondria-targeted antioxidants have demonstrated improvement in mitochondrial function and oxidative stress in pre-clinical diabetes models,the results regarding glycemic control have been mixed,and no studies have evaluated their hypoglycemic effects in diabetic patients.Nonetheless,pre-clinical trials have shown promising outcomes in ameliorating diabetes-related complications.Here,we review some reasons why mitochondria-targeted antioxidants may not function effectively in the context of mitochondrial dysfunction.We also highlight several alternative approaches under development that may enhance the targeting of mitochondria for diabetes treatment.展开更多
There were signi cant differences in energy metabolism between normal and tumor cells(normal cells depend on mitochondrial respiration for energy supply,while tumor cells rely on aerobic glycolysis)^([1,2]).Based on t...There were signi cant differences in energy metabolism between normal and tumor cells(normal cells depend on mitochondrial respiration for energy supply,while tumor cells rely on aerobic glycolysis)^([1,2]).Based on this difference,this study aims to provide a new therapeutic strategy for precise radiation protection of normal cells through utilizing selective autophagy induced by MitoQ-constructed pseudo-mitochondrial membrane potential(PMMP)by targeting mitochondrial respiration.Normal cells HA.展开更多
基金Supported by Instituto de Ciencia,Tecnología e Innovación-Gobierno del Estado de Michoacán,México,No.ICTI-PICIR23-063Programa Proyectos de Investigación Financiados 2024,Coordinación de Investigación Científica,Universidad Michoacana de San Nicolás de Hidalgo,México.
文摘In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin secretion.Despite numerous in vitro and pre-clinical studies supporting the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of diabetes and its complications,efforts to target mitochondria for glycemic control in diabetes using mitochondria-targeted antioxidants have produced inconsistent results.The intricate functionality of mitochondria is summarized to underscore the challenges it poses as a therapeutic target.While mitochondria-targeted antioxidants have demonstrated improvement in mitochondrial function and oxidative stress in pre-clinical diabetes models,the results regarding glycemic control have been mixed,and no studies have evaluated their hypoglycemic effects in diabetic patients.Nonetheless,pre-clinical trials have shown promising outcomes in ameliorating diabetes-related complications.Here,we review some reasons why mitochondria-targeted antioxidants may not function effectively in the context of mitochondrial dysfunction.We also highlight several alternative approaches under development that may enhance the targeting of mitochondria for diabetes treatment.
基金Fellow of Youth Innovation Promotion Association(2020414)Key Program of Natural Science Foundation of Gansu Province(21JR7RA097)。
文摘There were signi cant differences in energy metabolism between normal and tumor cells(normal cells depend on mitochondrial respiration for energy supply,while tumor cells rely on aerobic glycolysis)^([1,2]).Based on this difference,this study aims to provide a new therapeutic strategy for precise radiation protection of normal cells through utilizing selective autophagy induced by MitoQ-constructed pseudo-mitochondrial membrane potential(PMMP)by targeting mitochondrial respiration.Normal cells HA.
