Histopathological examination is still the gold standard for diagnoses of oral-maxillofacial lesions,but it is invasive and time-consuming.Optical coherence tomography(OCT)provides a kind of noninvasive,label-free,rea...Histopathological examination is still the gold standard for diagnoses of oral-maxillofacial lesions,but it is invasive and time-consuming.Optical coherence tomography(OCT)provides a kind of noninvasive,label-free,real-time and high-resolution imaging technology.In this study,in order to assess the feasibility of OCT in oral clinical application,fresh excised tissue specimens from 59 patients undergoing oral-maxillofacial surgery were imaged in detail by using a benchtop sweptsource OCT system.It is shown that different lesions or tissues can be obviously distinguished based on their different microstructural features in OCT images,and the features are similar to those of their corresponding histopathological images.It is proven that OCT has great feasibility and potential as a diagnostic aid for surgeons in oral medicine.展开更多
[目的]探讨乳腺容积成像(Volume Imaging for Breast Assessment,VIBRANT)技术诊断乳腺肿块性病变的临床价值。[方法]对52例(57灶)经病理证实的女性乳腺患者术前行VIBRANT动态增强检查。分析良恶性病变VIBRANT动态增强形态学特征及时间...[目的]探讨乳腺容积成像(Volume Imaging for Breast Assessment,VIBRANT)技术诊断乳腺肿块性病变的临床价值。[方法]对52例(57灶)经病理证实的女性乳腺患者术前行VIBRANT动态增强检查。分析良恶性病变VIBRANT动态增强形态学特征及时间-信号强度曲线(Time-Signal intensity Curves,TIC)。采用评分法根据积分情况进行综合定性诊断。[结果]利用毛刺征鉴别乳腺良恶性病变的特异度97.1%(33/34)。乳腺恶性病变的TIC类型中III型比例最大,占14/23;乳腺良性病变的TIC类型中Ⅰ型比例最大,占19/34。乳腺良恶性病变的信号增强比率(Signal Enhancement Ratio,SER)差异有显著性意义(t=3.243,P<0.01),以恶性病变的95%CI上界作为SER值的阈值即1.33。通过对乳腺病变VIBRANT动态增强形态学和TIC类型综合的评分诊断乳腺病变的敏感度、特异度和阳性似然比、阴性似然比分别为86.96%(20/23)、85.29%(29/34)和5.913、0.153,诊断符合率为86.0%;通过对乳腺病变SER值的评分诊断乳腺病变的敏感度、特异度和阳性似然比、阴性似然比分别为82.6%(19/23)、82.4%(28/34)和4.681、0.211,诊断符合率为82.5%;联合VIBRANT动态增强形态学、TIC的分型和半定量参数值诊断乳腺病变良恶性的敏感度、特异度和阳性似然比、阴性似然比分别为91.3%(21/23)、88.2%(30/34)和7.761、0.099,诊断符合率为89.5%。[结论]VIBRANT技术对乳腺肿块性病变的诊断可提供更有价值和更接近真实的信息。病灶边缘的毛刺征是VIBRANT动态增强鉴别乳腺良恶性肿块性病变特异度较高的征象。将乳腺MR VIBRANT的形态学与血流动力学表现相结合,可以提高乳腺病变诊断的准确率。当病灶形态学、TIC类型可疑恶性时,SER值能提供更有价值的信息。展开更多
局灶性白质损伤(punctate white matter lesions,PWML)是婴儿期最为常见的白质损伤性疾病(发生率超过20%),可引起不良神经发育结局,严重威胁患儿的身心健康发展。该损伤具有多变性及扩展性,可导致广泛脑结构及功能变化。笔者主要阐述了P...局灶性白质损伤(punctate white matter lesions,PWML)是婴儿期最为常见的白质损伤性疾病(发生率超过20%),可引起不良神经发育结局,严重威胁患儿的身心健康发展。该损伤具有多变性及扩展性,可导致广泛脑结构及功能变化。笔者主要阐述了PWML病灶特征及其预后评估方面的研究进展,指出现有损伤评估中存在的问题并进行展望。展开更多
基金supported by National Natural Science Foundation of China(NSFC)(61875092 and 11374167)State Key Project of Research and Development Plan(2016YFC0101002)+1 种基金Science and Technology Support Program of Tianjin(17YFZCSY00740)Fundamental Research Funds for the Central Universities of Nankai University(63191203).
文摘Histopathological examination is still the gold standard for diagnoses of oral-maxillofacial lesions,but it is invasive and time-consuming.Optical coherence tomography(OCT)provides a kind of noninvasive,label-free,real-time and high-resolution imaging technology.In this study,in order to assess the feasibility of OCT in oral clinical application,fresh excised tissue specimens from 59 patients undergoing oral-maxillofacial surgery were imaged in detail by using a benchtop sweptsource OCT system.It is shown that different lesions or tissues can be obviously distinguished based on their different microstructural features in OCT images,and the features are similar to those of their corresponding histopathological images.It is proven that OCT has great feasibility and potential as a diagnostic aid for surgeons in oral medicine.
文摘[目的]探讨乳腺容积成像(Volume Imaging for Breast Assessment,VIBRANT)技术诊断乳腺肿块性病变的临床价值。[方法]对52例(57灶)经病理证实的女性乳腺患者术前行VIBRANT动态增强检查。分析良恶性病变VIBRANT动态增强形态学特征及时间-信号强度曲线(Time-Signal intensity Curves,TIC)。采用评分法根据积分情况进行综合定性诊断。[结果]利用毛刺征鉴别乳腺良恶性病变的特异度97.1%(33/34)。乳腺恶性病变的TIC类型中III型比例最大,占14/23;乳腺良性病变的TIC类型中Ⅰ型比例最大,占19/34。乳腺良恶性病变的信号增强比率(Signal Enhancement Ratio,SER)差异有显著性意义(t=3.243,P<0.01),以恶性病变的95%CI上界作为SER值的阈值即1.33。通过对乳腺病变VIBRANT动态增强形态学和TIC类型综合的评分诊断乳腺病变的敏感度、特异度和阳性似然比、阴性似然比分别为86.96%(20/23)、85.29%(29/34)和5.913、0.153,诊断符合率为86.0%;通过对乳腺病变SER值的评分诊断乳腺病变的敏感度、特异度和阳性似然比、阴性似然比分别为82.6%(19/23)、82.4%(28/34)和4.681、0.211,诊断符合率为82.5%;联合VIBRANT动态增强形态学、TIC的分型和半定量参数值诊断乳腺病变良恶性的敏感度、特异度和阳性似然比、阴性似然比分别为91.3%(21/23)、88.2%(30/34)和7.761、0.099,诊断符合率为89.5%。[结论]VIBRANT技术对乳腺肿块性病变的诊断可提供更有价值和更接近真实的信息。病灶边缘的毛刺征是VIBRANT动态增强鉴别乳腺良恶性肿块性病变特异度较高的征象。将乳腺MR VIBRANT的形态学与血流动力学表现相结合,可以提高乳腺病变诊断的准确率。当病灶形态学、TIC类型可疑恶性时,SER值能提供更有价值的信息。
文摘局灶性白质损伤(punctate white matter lesions,PWML)是婴儿期最为常见的白质损伤性疾病(发生率超过20%),可引起不良神经发育结局,严重威胁患儿的身心健康发展。该损伤具有多变性及扩展性,可导致广泛脑结构及功能变化。笔者主要阐述了PWML病灶特征及其预后评估方面的研究进展,指出现有损伤评估中存在的问题并进行展望。
