In this paper,a new GLKKM type theorem is established for noncompact complete L-convex metric spaces.As applications,the properties of the solution set of variational in-equalities,intersection point sets,Ky Fan secti...In this paper,a new GLKKM type theorem is established for noncompact complete L-convex metric spaces.As applications,the properties of the solution set of variational in-equalities,intersection point sets,Ky Fan sections and maximal element sets are shown,and a Fan-Browder fixed point theorem is obtained.展开更多
Nanog protein is expressed in the interior cells of compacted morulae and maintained till epiblasts but downregulated by implantation stage. It is also expressed in embryonic stem cells, embryonic carcinoma cells and ...Nanog protein is expressed in the interior cells of compacted morulae and maintained till epiblasts but downregulated by implantation stage. It is also expressed in embryonic stem cells, embryonic carcinoma cells and embryonic germ cells but disappeared in differentiated ES cells. In this study, we have isolated, sequenced, and performed the first characterization of the Nanog promoter. The transcription start sites were mapped by primer extension analysis. Two promoter regions were found upstream the transcription start sites and the expression of major Nanog promoter/ reporter gene construct is abolished in differentiated F9 EC cells as compared to the undifferentiated counterpart. We also showed that a putative octamer motif (ATGCAAAA) is necessary for the major promoter activity. Gel shift and supershift assays showed that Oct-1, Oct-4 and Oct-6 protein selectively bind to the octamer motif.展开更多
目的:探讨颅内压参数联合血清小窝蛋白-1(caveolin-1)、水通道蛋白4(AQP-4)对高血压脑出血(HICH)患者术后预后不良的预测价值。方法:选择2020年1月至2022年1月河北省胸科医院收治的106例HICH患者,术后随访3个月,根据格拉斯哥预后(GOS)...目的:探讨颅内压参数联合血清小窝蛋白-1(caveolin-1)、水通道蛋白4(AQP-4)对高血压脑出血(HICH)患者术后预后不良的预测价值。方法:选择2020年1月至2022年1月河北省胸科医院收治的106例HICH患者,术后随访3个月,根据格拉斯哥预后(GOS)评分将患者分为预后良好组(55例),预后不良组(51例)。术后监测颅内压参数[压力反应指数(PRx)、平均颅内压波幅(MWA)、20 mm Hg阈值下颅内压剂量(Dicp20)],检测血清caveolin-1、AQP-4水平。多因素Logistic回归分析HICH患者术后预后不良的因素。受试者工作特征曲线(ROC)分析颅内压参数联合血清caveolin-1、AQP-4预测HICH患者术后预后不良的价值。结果:预后不良组PRx、MWA、Dicp20以及血清caveolin-1、AQP-4水平高于预后良好组(P<0.05)。低术前格拉斯哥昏迷评分(GCS)评分、高PRx、高Dicp20、高caveolin-1、高AQP-4是HICH患者术后预后不良的危险因素(P<0.05)。联合PRx、Dicp20、caveolin-1和AQP-4预测HICH患者术后3个月预后不良的的曲线下面积为0.823,大于PRx、Dicp20、caveolin-1和AQP-4单独预测。结论:高PRx、Dicp20、caveolin-1、AQP4是HICH患者术后预后不良的危险因素,联合颅内压参数PRx、Dicp20及血清caveolin-1、AQP4预测HICH患者术后预后不良具有较高的价值。展开更多
基金Foundation item： the Natural Science Research Foundation of Guizhou Provincial Education Department （No. 2008072） the Natural Science Foundation of Science and Technologe Bureau of Bijie Area （No. 2008-06）.
文摘In this paper,a new GLKKM type theorem is established for noncompact complete L-convex metric spaces.As applications,the properties of the solution set of variational in-equalities,intersection point sets,Ky Fan sections and maximal element sets are shown,and a Fan-Browder fixed point theorem is obtained.
文摘Nanog protein is expressed in the interior cells of compacted morulae and maintained till epiblasts but downregulated by implantation stage. It is also expressed in embryonic stem cells, embryonic carcinoma cells and embryonic germ cells but disappeared in differentiated ES cells. In this study, we have isolated, sequenced, and performed the first characterization of the Nanog promoter. The transcription start sites were mapped by primer extension analysis. Two promoter regions were found upstream the transcription start sites and the expression of major Nanog promoter/ reporter gene construct is abolished in differentiated F9 EC cells as compared to the undifferentiated counterpart. We also showed that a putative octamer motif (ATGCAAAA) is necessary for the major promoter activity. Gel shift and supershift assays showed that Oct-1, Oct-4 and Oct-6 protein selectively bind to the octamer motif.
文摘目的:探讨颅内压参数联合血清小窝蛋白-1(caveolin-1)、水通道蛋白4(AQP-4)对高血压脑出血(HICH)患者术后预后不良的预测价值。方法:选择2020年1月至2022年1月河北省胸科医院收治的106例HICH患者,术后随访3个月,根据格拉斯哥预后(GOS)评分将患者分为预后良好组(55例),预后不良组(51例)。术后监测颅内压参数[压力反应指数(PRx)、平均颅内压波幅(MWA)、20 mm Hg阈值下颅内压剂量(Dicp20)],检测血清caveolin-1、AQP-4水平。多因素Logistic回归分析HICH患者术后预后不良的因素。受试者工作特征曲线(ROC)分析颅内压参数联合血清caveolin-1、AQP-4预测HICH患者术后预后不良的价值。结果:预后不良组PRx、MWA、Dicp20以及血清caveolin-1、AQP-4水平高于预后良好组(P<0.05)。低术前格拉斯哥昏迷评分(GCS)评分、高PRx、高Dicp20、高caveolin-1、高AQP-4是HICH患者术后预后不良的危险因素(P<0.05)。联合PRx、Dicp20、caveolin-1和AQP-4预测HICH患者术后3个月预后不良的的曲线下面积为0.823,大于PRx、Dicp20、caveolin-1和AQP-4单独预测。结论:高PRx、Dicp20、caveolin-1、AQP4是HICH患者术后预后不良的危险因素,联合颅内压参数PRx、Dicp20及血清caveolin-1、AQP4预测HICH患者术后预后不良具有较高的价值。
