目的:系统评价补肾中药联合达英-35治疗多囊卵巢综合征(PCOS)的疗效及安全性。方法:计算机检索相关中英文数据库关于补肾中药联合达英-35治疗PCOS的随机对照试验(RCT),各数据库检索时间均由建库至2017年2月。对符合纳入和排除标准的文...目的:系统评价补肾中药联合达英-35治疗多囊卵巢综合征(PCOS)的疗效及安全性。方法:计算机检索相关中英文数据库关于补肾中药联合达英-35治疗PCOS的随机对照试验(RCT),各数据库检索时间均由建库至2017年2月。对符合纳入和排除标准的文献进行数据提取及方法学质量评价,应用Rev Man 5.3软件作Meta分析。结果:共纳入文献22篇,1676例患者。Meta分析结果显示:补肾中药联合达英-35与单用达英-35组对比,联合用药组总有效率更高[OR=4.22,95%CI(2.86,6.23),P<0.00001],雄激素[MD=-0.45,95%CI(-0.67,-0.22),P<0.0001]、促黄体生成素[MD=-1.84,95%CI(-1.98,-1.70),P<0.00001]、LH/FSH值[MD=-0.25,95%CI(-0.44,-0.06),P=0.009]等性激素水平改善均优于单用西药组,并能明显提高妊娠率[OR=3.34,95%CI(2.23,5.02),P<0.00001],且未出现明显不良反应。结论:现有证据显示补肾中药联合达英-35治疗PCOS疗效显著,能明显改善性激素水平,提高总有效率及妊娠率,不良反应少,可供临床参考与应用。展开更多
目的:评价补肾类中药治疗强直性脊柱炎的临床疗效。方法:计算机检索数据库包括美国医学文摘数据库(PubMed)、中国知网(CNKI)、万方学术期刊数据库(WanFang Dat a)、维普中文期刊数据库(VIP)等,收集单用西药治疗(柳氮磺胺吡啶,SASP)与补...目的:评价补肾类中药治疗强直性脊柱炎的临床疗效。方法:计算机检索数据库包括美国医学文摘数据库(PubMed)、中国知网(CNKI)、万方学术期刊数据库(WanFang Dat a)、维普中文期刊数据库(VIP)等,收集单用西药治疗(柳氮磺胺吡啶,SASP)与补肾类中药治疗强直性脊柱炎的随机对照试验(RCT),采用Rev Man5.3软件进行Met a分析。结果:29篇文献符合纳入要求,共计2565例患者,其中中药组1384例,西药组1181例。Met a分析结果显示补肾类中药治疗强直性脊柱炎的有效率优于西药(SASP)[OR=3.61,95%CI (2.91,4.47)]。结论:补肾类中药与西药(SASP)相比,临床疗效较好,不良反应少。但所纳入的临床研究仅2篇属高质量文献,其余文献质量相对偏低,因此需要更多高质量、多中心的随机双盲临床研究进一步补充验证。展开更多
Objective To investigate the mechanisms through which kidney-tonifying herbs（KTHs） and liver-clearing herbs（LCHs） in Dingjing Decoction（DJD） regulate premature ovarian failure（POF）. Methods One hundred and fif...Objective To investigate the mechanisms through which kidney-tonifying herbs（KTHs） and liver-clearing herbs（LCHs） in Dingjing Decoction（DJD） regulate premature ovarian failure（POF）. Methods One hundred and fifty Sprague-Dawley rats were randomly divided into five groups such as control, model, KTHs, LCHs, and DJD groups. POF-related biological molecules were examined. Factor analysis was performed to investigate the regulatory networks and key biomolecules involved in mediating POF after treatment with KTHs and LCHs. Results The master regulatory factors in the reproductive endocrine network associated with KTHs intervention included four molecules in the pituitary-ovarian axis, cortisol（CORT） in the target gland of pituitary-adrenal axis, and some molecules in the hypothalamus. In contrast, the master regulatory factors associated with LCHs intervention included four molecules in the pituitary-ovarian axis and some molecules in the hypothalamus; No biomolecules in the pituitary-adrenal axis were involved in the LCH-mediated mechanisms.Gonadotropin-releasing hormone（Gn RH）, which was identified as a common biological molecule in the hypothalamus, was involved in regulating the reproductive endocrine network in association with KTHs intervention. Conclusion KTHs directly regulates biological molecules in the pituitary-adrenal axis and indirectly regulates those in the pituitary-adrenal axis through the hypothalamus, while the LCHs only exert its effects indirectly. Gn RH is the key biological molecule associated with KTHs intervention.展开更多
文摘目的:系统评价补肾中药联合达英-35治疗多囊卵巢综合征(PCOS)的疗效及安全性。方法:计算机检索相关中英文数据库关于补肾中药联合达英-35治疗PCOS的随机对照试验(RCT),各数据库检索时间均由建库至2017年2月。对符合纳入和排除标准的文献进行数据提取及方法学质量评价,应用Rev Man 5.3软件作Meta分析。结果:共纳入文献22篇,1676例患者。Meta分析结果显示:补肾中药联合达英-35与单用达英-35组对比,联合用药组总有效率更高[OR=4.22,95%CI(2.86,6.23),P<0.00001],雄激素[MD=-0.45,95%CI(-0.67,-0.22),P<0.0001]、促黄体生成素[MD=-1.84,95%CI(-1.98,-1.70),P<0.00001]、LH/FSH值[MD=-0.25,95%CI(-0.44,-0.06),P=0.009]等性激素水平改善均优于单用西药组,并能明显提高妊娠率[OR=3.34,95%CI(2.23,5.02),P<0.00001],且未出现明显不良反应。结论:现有证据显示补肾中药联合达英-35治疗PCOS疗效显著,能明显改善性激素水平,提高总有效率及妊娠率,不良反应少,可供临床参考与应用。
基金National Natural Science Foundation of China(No.81073073,No.81403153)
文摘Objective To investigate the mechanisms through which kidney-tonifying herbs（KTHs） and liver-clearing herbs（LCHs） in Dingjing Decoction（DJD） regulate premature ovarian failure（POF）. Methods One hundred and fifty Sprague-Dawley rats were randomly divided into five groups such as control, model, KTHs, LCHs, and DJD groups. POF-related biological molecules were examined. Factor analysis was performed to investigate the regulatory networks and key biomolecules involved in mediating POF after treatment with KTHs and LCHs. Results The master regulatory factors in the reproductive endocrine network associated with KTHs intervention included four molecules in the pituitary-ovarian axis, cortisol（CORT） in the target gland of pituitary-adrenal axis, and some molecules in the hypothalamus. In contrast, the master regulatory factors associated with LCHs intervention included four molecules in the pituitary-ovarian axis and some molecules in the hypothalamus; No biomolecules in the pituitary-adrenal axis were involved in the LCH-mediated mechanisms.Gonadotropin-releasing hormone（Gn RH）, which was identified as a common biological molecule in the hypothalamus, was involved in regulating the reproductive endocrine network in association with KTHs intervention. Conclusion KTHs directly regulates biological molecules in the pituitary-adrenal axis and indirectly regulates those in the pituitary-adrenal axis through the hypothalamus, while the LCHs only exert its effects indirectly. Gn RH is the key biological molecule associated with KTHs intervention.
