Objective： To observe the metabolic, regulatory and anti-oxidative effects of modified Bushen Huoxue Decoction （BSHXD, 补肾活血方）, a Chinese herbal medicine for Kidney （Shen）-reinforcement and bloodactivation, o...Objective： To observe the metabolic, regulatory and anti-oxidative effects of modified Bushen Huoxue Decoction （BSHXD, 补肾活血方）, a Chinese herbal medicine for Kidney （Shen）-reinforcement and bloodactivation, on an osteoarthritis （OA） rabbit model. Methods： A rabbit model for knee joint OA was established by the classic Huith＇s method. The OA model rabbits were randomized into 5 groups： the model control group, the positive control group treated with glucosamine sulfate, and the three BSHXD treated groups treated respectively with low, moderate, and high doses of BSHXD. In addition, a normal control group and a sham-operated group were set up. Experimental animals were sacrificed after a 7-week treatment, and pathological changes in cartilaginous tissue were estimated using the Mankin criteria. Hydroxyproline （Hyp） and malonaldehyde （MDA） contents in blood serum and urine, as well as superoxide dismutase （SOD） activity and nitric oxide （NO） content in blood serum and knee joint synovial homogenates were detected. Results： Mankin scoring showed insignificant statistical differences between the various treatment groups （P〉0.05）, but all were better than the model control group （P〈0.05）. Serum and udnary contents of Hyp and MDA as well as serum and synovial levels of NO were significantly lower, but the SOD activity in blood serum and synovial tissue was higher in the BSHXD treated groups than in the model group （P〈0.01）; the effect of BSHXD was dose-dependent to some extent. Coaclasloa： The modified BSHXD shows an effect of improving cartilage metabolism in experimental rabbits with OA, and possesses osteo-chondric protective effects in antagonizing peroxidation injury.展开更多
OBJECTIVE:To compare the efficacy of modified treatments based on "kidney reinforcing" in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and e...OBJECTIVE:To compare the efficacy of modified treatments based on "kidney reinforcing" in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),"kidney reinforcing and Qi tonifying"(KQ),and "kidney reinforcing and blood circulation invigorating"(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery.展开更多
OBJECTIVE:The aim of this study was to evaluate the effectiveness of Chinese herbal medicines for invigorating the kidney(CHMIK)on senile osteoporosis.METHODS:We searched for studies in English-language databases(Pub ...OBJECTIVE:The aim of this study was to evaluate the effectiveness of Chinese herbal medicines for invigorating the kidney(CHMIK)on senile osteoporosis.METHODS:We searched for studies in English-language databases(Pub Med,the Cochrane Library,and Web of Science)and Chinese-language databases(China National Knowledge Infrastructure,Wan Fang Data,VIP Chinese periodical service platform),and China Biology Medicine disc from their inception to September 2017.Randomized controlled trials comparing the effectiveness of Traditional Chinese Medicine therapies(alone or in combination)and conventional clinical medicine therapies among older adult patients with osteoporosis were identified.We conducted a network Meta-analysis with a Bayesian hierarchical random-effects model using RStudio software,Version 3.4.1.RESULTS:Forty-three randomized controlled trials assessing the differences between Traditional Chinese Medicine and conventional clinical medicine were identified,including 15 treatments and involving 3316 patients.The results of the network Meta-analysis indicated that alendronate(odds ratio[OR]=0.20,95%confidence interval[CI]:0.047-0.73)and calcium(OR=0.18,95%CI:0.11-0.30)are significantly more effective if combined with oral CHMIK.CHMIK alone is significantly more effective than both alendronate(OR=0.34,95%CI:0.10-1.0)and calcium(OR=0.13,95%CI:0.056-0.28).Moreover,CHMIK+tuina+calcium is more effective than CHMIK+calcium+vitamin D+alendronate(OR=18.0,95%CI:1.1-2.7 e+02).CONCLUSION:The present network Meta-analysis found that alendronate and calcium are more effective if combined with oral CHMIK and that oral CHMIK alone may be more effective than alendronate or calcium.Tuina may have an advantage over oral medicines.Oral CHMIK and calcitonin show the most potential for treating senile osteoporosis.展开更多
In Traditional Chinese Medicine(TCM),the'tonifying kidney and benefiting marrow'(TKBM)method is based on the theory that kidney controls bones,while marrow moistens bones.There have been aboundant theoretical ...In Traditional Chinese Medicine(TCM),the'tonifying kidney and benefiting marrow'(TKBM)method is based on the theory that kidney controls bones,while marrow moistens bones.There have been aboundant theoretical studies on kidney controlling bones since Huangdi's Internal Classics.Howev-er,there are too few ones about the marrow moistening the bones.Researchers generally use the tonifying kidney method instead of the TKBM method,which causes lack of a unified standard and theoretical basis in evaluating the TKBM method.Herein,we first proposed the hypothesis that deficiency of marrow sea causes osteoporosis.Next,we prove the scientific validity of this hypothesis from the side of the TCM theory on the relationship among kidney,bone and marrow sea physiologically and pathologically.Based on this,we find that the TCM theory provides theoretical basis for deficiency of marrow sea causing osteoporosis.On the other side,Western Medicine theory holds that(a)physiologically,the brain regulates the bone mass via three pathways:the neuro-osteogenic network,neuro-endocrine-bone network,and neuropeptide-bone network;(b)pathologically,brain impacts bone mass via three major passways including the regulation of the sympathetic nervous system,secreting hormones that directly act on bone cells and regulating the synthesis and secretion of hormones in the intermediary organs,and neuropeptides such as neuropeptide Y(NPY),substance P(SP),and calcitonin gene-related peptide(CGRP).Evidences involving estrogen deficiency,sympatheticotonia,or neuropeptides imbalance prove that brain-bone mass regulation plays an important role in the pathogenesis of osteoporosis.Finally,we find that kidney invigoration method can change the concentrations of central neurotransmitters of norepinephrine and glutamate to regulate neuro-osteogenic network,and promote the recovery of ovarian function and have an estrogen-like effect by regulating the hypothalamus-pituitary-ovarian axis,which thus influences bone metabolism without clinically significant estro展开更多
目的:探究补肾益气活血方剂对2型糖尿病(T2DM)患者脑记忆功能、脑诱发电位的影响。方法:选取2015年3月至2016年12月南京医科大学第一附属医院收治的T2DM患者87例作为研究对象,按照随机数字表法随机分为对照组(n=43)和观察组(n=44),对照...目的:探究补肾益气活血方剂对2型糖尿病(T2DM)患者脑记忆功能、脑诱发电位的影响。方法:选取2015年3月至2016年12月南京医科大学第一附属医院收治的T2DM患者87例作为研究对象,按照随机数字表法随机分为对照组(n=43)和观察组(n=44),对照组给予常规降糖、营养神经治疗,观察组在此基础上联合补肾益气活血方剂治疗,治疗3个月。比较2组临床疗效、血糖水平、脑干听觉诱发电位及脑记忆功能。结果:治疗后观察组总有效率为93.18%,高于对照组(72.09%,P<0.01);与治疗前比较,治疗后2组血清FPG、2 h PG及观察组血清HbA1c水平降低(P<0.01),且观察组低于对照组(P<0.05);2组人像特点联系回忆、无意义图形再认评分及观察组指向学习、联想学习、图像自由记忆、记忆商评分升高,且观察组高于对照组(P<0.05)。与治疗前比较,治疗后观察组Ⅰ、Ⅴ波潜伏期及2组Ⅲ波潜伏期、Ⅲ-Ⅴ波峰间期缩短,观察组短于对照组(P<0.05)。结论:在常规治疗的基础上联合补肾益气活血方剂可有效降低T2DM患者血糖水平,改善其脑记忆功能及脑干听觉诱发电位,有效缓解患者脑功能减退症状,值得临床推广。展开更多
In this case,the acupuncture treatment for open-angle glaucoma patient achieved a significant result.The acupoints Jingming(睛明BL1),Qiuhou(球后Extra),Fengchi(风池GB20),and Taichong(太冲LR3)were used as the main ones ...In this case,the acupuncture treatment for open-angle glaucoma patient achieved a significant result.The acupoints Jingming(睛明BL1),Qiuhou(球后Extra),Fengchi(风池GB20),and Taichong(太冲LR3)were used as the main ones plus some symptomatic acupoints.After one course of treatment,the left eye pressure decreased by 12 mmHg compared with that before treatment,the left eye vision improved,and the fundus oozing was significantly reduced.After two courses of treatment,the left eye pressure was below 20 mmHg,left eye vision obviously improved,and the fundus oozing completely disappeared.展开更多
基金Supported by Practice Basic Research Plan of Tianjin City(No. 06YFJMJC09600)
文摘Objective： To observe the metabolic, regulatory and anti-oxidative effects of modified Bushen Huoxue Decoction （BSHXD, 补肾活血方）, a Chinese herbal medicine for Kidney （Shen）-reinforcement and bloodactivation, on an osteoarthritis （OA） rabbit model. Methods： A rabbit model for knee joint OA was established by the classic Huith＇s method. The OA model rabbits were randomized into 5 groups： the model control group, the positive control group treated with glucosamine sulfate, and the three BSHXD treated groups treated respectively with low, moderate, and high doses of BSHXD. In addition, a normal control group and a sham-operated group were set up. Experimental animals were sacrificed after a 7-week treatment, and pathological changes in cartilaginous tissue were estimated using the Mankin criteria. Hydroxyproline （Hyp） and malonaldehyde （MDA） contents in blood serum and urine, as well as superoxide dismutase （SOD） activity and nitric oxide （NO） content in blood serum and knee joint synovial homogenates were detected. Results： Mankin scoring showed insignificant statistical differences between the various treatment groups （P〉0.05）, but all were better than the model control group （P〈0.05）. Serum and udnary contents of Hyp and MDA as well as serum and synovial levels of NO were significantly lower, but the SOD activity in blood serum and synovial tissue was higher in the BSHXD treated groups than in the model group （P〈0.01）; the effect of BSHXD was dose-dependent to some extent. Coaclasloa： The modified BSHXD shows an effect of improving cartilage metabolism in experimental rabbits with OA, and possesses osteo-chondric protective effects in antagonizing peroxidation injury.
基金Supported by Special Item of Important Disease of Zhejiang Province Traditional Chinese Medicine Sic-Tech Innovation Platform(Effect and Mechanism of Traditional Chinese Medicine on the Treatment of Aplastic Anemia and the Funding of Traditional Chinese Medicine Assessment Criterion,No.2009ZDJB01)Subject of Key Sic-Tech Innovation Team of Zhejiang Province(Clinical Study on Treatment of Chronic Aplastic Anemia by Tonifying Kidney and Promoting Blood Circulation,No.2011R09042-02)+2 种基金Special Research Funds for Traditional Chinese Medicine Industry(Effect of Traditional Chinese Medicine on the Treatment of Risk Factors of Chronic Aplastic Anemia,No.201107001)Special Research Funds for Traditional Chinese Medicine Industry(Clinical Study on the Diagnosis and Treatment of Aplastic Anemia Based on the Syndrome And Stage Differentiation,No.201407001)Zhejiang Provincial Traditional Chinese Medicine Administration Bureau Program(Establishment of Traditional Chinese Medicine Clinical Pathway on Aplastic Anemia,No.2010ZA039)
文摘OBJECTIVE:To compare the efficacy of modified treatments based on "kidney reinforcing" in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),"kidney reinforcing and Qi tonifying"(KQ),and "kidney reinforcing and blood circulation invigorating"(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery.
基金Supported by the National Natural Science Foundation of China"Kidney Health Bone,Marrow Link Brain",a Study of Chinese Nourishing Kidney Herbs’Mechanism of Treatment of Osteoporosis Based on Neuropeptide Network"Too Salty to Hurt the Bone",A Study on the Molecular Mechanism of High Salt Affecting Bone Metabolism Based on Related Ion Channels and Intervention of A Compound Chinese Medicine for Reinforcing Kidney(No.81473509,81673837).
文摘OBJECTIVE:The aim of this study was to evaluate the effectiveness of Chinese herbal medicines for invigorating the kidney(CHMIK)on senile osteoporosis.METHODS:We searched for studies in English-language databases(Pub Med,the Cochrane Library,and Web of Science)and Chinese-language databases(China National Knowledge Infrastructure,Wan Fang Data,VIP Chinese periodical service platform),and China Biology Medicine disc from their inception to September 2017.Randomized controlled trials comparing the effectiveness of Traditional Chinese Medicine therapies(alone or in combination)and conventional clinical medicine therapies among older adult patients with osteoporosis were identified.We conducted a network Meta-analysis with a Bayesian hierarchical random-effects model using RStudio software,Version 3.4.1.RESULTS:Forty-three randomized controlled trials assessing the differences between Traditional Chinese Medicine and conventional clinical medicine were identified,including 15 treatments and involving 3316 patients.The results of the network Meta-analysis indicated that alendronate(odds ratio[OR]=0.20,95%confidence interval[CI]:0.047-0.73)and calcium(OR=0.18,95%CI:0.11-0.30)are significantly more effective if combined with oral CHMIK.CHMIK alone is significantly more effective than both alendronate(OR=0.34,95%CI:0.10-1.0)and calcium(OR=0.13,95%CI:0.056-0.28).Moreover,CHMIK+tuina+calcium is more effective than CHMIK+calcium+vitamin D+alendronate(OR=18.0,95%CI:1.1-2.7 e+02).CONCLUSION:The present network Meta-analysis found that alendronate and calcium are more effective if combined with oral CHMIK and that oral CHMIK alone may be more effective than alendronate or calcium.Tuina may have an advantage over oral medicines.Oral CHMIK and calcitonin show the most potential for treating senile osteoporosis.
基金Supported by National Natural Science Foundation of China-Founded Projects:Multi-modality f MRI Study on Brain-bone Mass Regulation in Postmenopausal Osteoporosis Patients Intervented by Catgut Embedding in Points(No.81574064)In Vivo Investigation on Brain Neural Activation and Glutamate and GABA of Perimenopausal Panic Disorder Treated by Catgut Embedding(No.81473755)+1 种基金Scientific Research Program of Administration of Traditional Chinese Medicine of Guangdong Province-Founded Project:Clinical Research on Brain-bone Regulation of Postmenopausal Osteoporosis Intervened by Catgut Embedded in Acupoint Based on Electroencephalogram(No.20181237)Shenzhen Science and Technology Planning Project:Resting f MRI Study on Postmenopausal Brain-bone Regulating Network Intervened by Catgut Embedding in Acupoints(No.JCYJ20170306152650625)
文摘In Traditional Chinese Medicine(TCM),the'tonifying kidney and benefiting marrow'(TKBM)method is based on the theory that kidney controls bones,while marrow moistens bones.There have been aboundant theoretical studies on kidney controlling bones since Huangdi's Internal Classics.Howev-er,there are too few ones about the marrow moistening the bones.Researchers generally use the tonifying kidney method instead of the TKBM method,which causes lack of a unified standard and theoretical basis in evaluating the TKBM method.Herein,we first proposed the hypothesis that deficiency of marrow sea causes osteoporosis.Next,we prove the scientific validity of this hypothesis from the side of the TCM theory on the relationship among kidney,bone and marrow sea physiologically and pathologically.Based on this,we find that the TCM theory provides theoretical basis for deficiency of marrow sea causing osteoporosis.On the other side,Western Medicine theory holds that(a)physiologically,the brain regulates the bone mass via three pathways:the neuro-osteogenic network,neuro-endocrine-bone network,and neuropeptide-bone network;(b)pathologically,brain impacts bone mass via three major passways including the regulation of the sympathetic nervous system,secreting hormones that directly act on bone cells and regulating the synthesis and secretion of hormones in the intermediary organs,and neuropeptides such as neuropeptide Y(NPY),substance P(SP),and calcitonin gene-related peptide(CGRP).Evidences involving estrogen deficiency,sympatheticotonia,or neuropeptides imbalance prove that brain-bone mass regulation plays an important role in the pathogenesis of osteoporosis.Finally,we find that kidney invigoration method can change the concentrations of central neurotransmitters of norepinephrine and glutamate to regulate neuro-osteogenic network,and promote the recovery of ovarian function and have an estrogen-like effect by regulating the hypothalamus-pituitary-ovarian axis,which thus influences bone metabolism without clinically significant estro
文摘目的:探究补肾益气活血方剂对2型糖尿病(T2DM)患者脑记忆功能、脑诱发电位的影响。方法:选取2015年3月至2016年12月南京医科大学第一附属医院收治的T2DM患者87例作为研究对象,按照随机数字表法随机分为对照组(n=43)和观察组(n=44),对照组给予常规降糖、营养神经治疗,观察组在此基础上联合补肾益气活血方剂治疗,治疗3个月。比较2组临床疗效、血糖水平、脑干听觉诱发电位及脑记忆功能。结果:治疗后观察组总有效率为93.18%,高于对照组(72.09%,P<0.01);与治疗前比较,治疗后2组血清FPG、2 h PG及观察组血清HbA1c水平降低(P<0.01),且观察组低于对照组(P<0.05);2组人像特点联系回忆、无意义图形再认评分及观察组指向学习、联想学习、图像自由记忆、记忆商评分升高,且观察组高于对照组(P<0.05)。与治疗前比较,治疗后观察组Ⅰ、Ⅴ波潜伏期及2组Ⅲ波潜伏期、Ⅲ-Ⅴ波峰间期缩短,观察组短于对照组(P<0.05)。结论:在常规治疗的基础上联合补肾益气活血方剂可有效降低T2DM患者血糖水平,改善其脑记忆功能及脑干听觉诱发电位,有效缓解患者脑功能减退症状,值得临床推广。
基金National Natural Science Foundation of China:8157151194。
文摘In this case,the acupuncture treatment for open-angle glaucoma patient achieved a significant result.The acupoints Jingming(睛明BL1),Qiuhou(球后Extra),Fengchi(风池GB20),and Taichong(太冲LR3)were used as the main ones plus some symptomatic acupoints.After one course of treatment,the left eye pressure decreased by 12 mmHg compared with that before treatment,the left eye vision improved,and the fundus oozing was significantly reduced.After two courses of treatment,the left eye pressure was below 20 mmHg,left eye vision obviously improved,and the fundus oozing completely disappeared.
