摘要
目的:探究补肾益气活血方剂对2型糖尿病(T2DM)患者脑记忆功能、脑诱发电位的影响。方法:选取2015年3月至2016年12月南京医科大学第一附属医院收治的T2DM患者87例作为研究对象,按照随机数字表法随机分为对照组(n=43)和观察组(n=44),对照组给予常规降糖、营养神经治疗,观察组在此基础上联合补肾益气活血方剂治疗,治疗3个月。比较2组临床疗效、血糖水平、脑干听觉诱发电位及脑记忆功能。结果:治疗后观察组总有效率为93.18%,高于对照组(72.09%,P<0.01);与治疗前比较,治疗后2组血清FPG、2 h PG及观察组血清HbA1c水平降低(P<0.01),且观察组低于对照组(P<0.05);2组人像特点联系回忆、无意义图形再认评分及观察组指向学习、联想学习、图像自由记忆、记忆商评分升高,且观察组高于对照组(P<0.05)。与治疗前比较,治疗后观察组Ⅰ、Ⅴ波潜伏期及2组Ⅲ波潜伏期、Ⅲ-Ⅴ波峰间期缩短,观察组短于对照组(P<0.05)。结论:在常规治疗的基础上联合补肾益气活血方剂可有效降低T2DM患者血糖水平,改善其脑记忆功能及脑干听觉诱发电位,有效缓解患者脑功能减退症状,值得临床推广。
Objective:To explore the effect of kidney-reinforcing,qi-replenishing and blood-activating prescription on brain memory function and brain evoked potential in patients with T2 DM.Methods:A total of 87 patients with T2 DM from March 2015 to December 2016 T2 DM were selected as the subjects,which were randomly divided into a control group(n=43) and an observation group(n=44).The control group was treated with conventional diabetes therapy and nerve nutrition therapy,while the observation group was treated with kidney-reinforcing,qi-replenishing and blood-activating prescription on the basis of control group,all of which were treated for 3 months.Clinical efficacy,blood glucose level,brainstem auditory evoked potential and brain memory function were compared between the 2 groups.Results:The clinical total effective rate of observation group was 93.18%,which was higher than the 72.09% of control group(P<0.01);compared with before treatment,the serum FPG,2 h PG in 2 groups and the serum HbA1 c levels in observation group decreased after treatment(P<0.01),and observation group was lower than control group(P<0.05);the scores of contact memories like characteristics,random shape recognition in 2 groups and the scores of pointing learning,associative learning,image free memory,memory quotient in observation group increased,and observation group was higher than control group(P<0.05);compared with those before treatment,the latency of Ⅰ and Ⅴ wave and the interval of Ⅲ wave and Ⅲ-Ⅴ wave were shorter in the observation group than in the control group(P<0.05).Conclusion:Kidney-reinforcing,qi-replenishing and blood-activating prescription on the basis of conventional therapy can effectively reduce the blood glucose level,improve the brain memory function and brain stem auditory evoked potential of T2 DM patients,and relieve the brain function impairment symptoms,which is worthy of clinical promotion.
作者
彭玲玲
段宇
PENG Lingling;DUAN Yu(Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《世界中医药》
CAS
2020年第24期3810-3813,共4页
World Chinese Medicine
基金
江苏省中医药科技计划项目(Y01-024)。
关键词
2型糖尿病
补肾益气活血方剂
脑记忆功能
脑诱发电位
Type 2 diabetes mellitus
Kidney-reinforcing,qi-replenishing and blood-activating prescription
Brain memory function
Brain evoked potential
