Timely diagnosis and control of cardiovascular risk factors is a priority objective for adequate primary and secondary prevention of acute stroke. Hypertension, atrial fibrillation and diabetes mellitus are the most c...Timely diagnosis and control of cardiovascular risk factors is a priority objective for adequate primary and secondary prevention of acute stroke. Hypertension, atrial fibrillation and diabetes mellitus are the most common risk factors for acute cerebrovascular events, although novel risk factors, such as sleep-disordered breathing, inflammatory markers or carotid intima-media thickness have been identified. However, the cardiovascular risk factors profile differs according to the different subtypes of ischemic stroke. Atrial fibrillation and ischemic heart disease are more frequent in patients with cardioembolic infarction, hypertension and diabetes in patients with lacunar stroke, and vascular peripheral disease, hypertension, diabetes, previous transient ischemic attack and chronic obstructive pulmonary disease in patients with atherothrombotic infarction. This review aims to present updated data on risk factors for acute ischemic stroke as well as to describe the usefulness of new and emerging vascular risk factors in stroke patients.展开更多
目的探讨ABCD3-I评分结合血清可溶性CD40配体(sCD40L)和血浆纤维蛋白原(Fib)检测对短暂性脑缺血发作(TIA)患者90d内发生脑梗死的预测价值。方法连续选取首次发病的TIA患者178例,随访90d,将发展为脑梗死的27例患者作为脑梗死组,未发展为...目的探讨ABCD3-I评分结合血清可溶性CD40配体(sCD40L)和血浆纤维蛋白原(Fib)检测对短暂性脑缺血发作(TIA)患者90d内发生脑梗死的预测价值。方法连续选取首次发病的TIA患者178例,随访90d,将发展为脑梗死的27例患者作为脑梗死组,未发展为脑梗死的151例患者作为对照组。入选者均进行ABCD3-I评分,采用酶联免疫吸附法检测sCD40L和Fib水平,绘制ROC曲线分析相关指标的预测价值。结果与对照组比较,脑梗死组ABCD3-I评分和sCD40L及Fib水平明显升高[(6.17±1.04)分vs (5.43±1.32)分,P=0.009;(222.00±28.75)μg/L vs (187.80±35.47)μg/L,P=0.014;(4.01±1.52)g/L vs (3.55±1.26)g/L,P=0.012]。ROC曲线分析显示,ABCD3-I评分联合sCD40L、ABCD3-I评分联合Fib、ABCD3-I评分联合sCD40L和Fib预测TIA患者90d内发展为脑梗死的曲线下面积分别为0.656(95%CI:0.586~0.732,P=0.001)、0.680(95%CI:0.615~0.745,P=0.000)和0.714(95%CI:0.654~0.774,P=0.000),均有预测价值,且ABCD3-I评分联合sCD40L和Fib的预测价值较前两者更高,其敏感性为90.1%,特异性为88.2%。结论 ABCD3-I评分联合sCD40L和Fib检测可进一步提高预测TIA患者90d内发展为脑梗死的准确率,且预测价值较高。展开更多
文摘Timely diagnosis and control of cardiovascular risk factors is a priority objective for adequate primary and secondary prevention of acute stroke. Hypertension, atrial fibrillation and diabetes mellitus are the most common risk factors for acute cerebrovascular events, although novel risk factors, such as sleep-disordered breathing, inflammatory markers or carotid intima-media thickness have been identified. However, the cardiovascular risk factors profile differs according to the different subtypes of ischemic stroke. Atrial fibrillation and ischemic heart disease are more frequent in patients with cardioembolic infarction, hypertension and diabetes in patients with lacunar stroke, and vascular peripheral disease, hypertension, diabetes, previous transient ischemic attack and chronic obstructive pulmonary disease in patients with atherothrombotic infarction. This review aims to present updated data on risk factors for acute ischemic stroke as well as to describe the usefulness of new and emerging vascular risk factors in stroke patients.
文摘目的探讨ABCD3-I评分结合血清可溶性CD40配体(sCD40L)和血浆纤维蛋白原(Fib)检测对短暂性脑缺血发作(TIA)患者90d内发生脑梗死的预测价值。方法连续选取首次发病的TIA患者178例,随访90d,将发展为脑梗死的27例患者作为脑梗死组,未发展为脑梗死的151例患者作为对照组。入选者均进行ABCD3-I评分,采用酶联免疫吸附法检测sCD40L和Fib水平,绘制ROC曲线分析相关指标的预测价值。结果与对照组比较,脑梗死组ABCD3-I评分和sCD40L及Fib水平明显升高[(6.17±1.04)分vs (5.43±1.32)分,P=0.009;(222.00±28.75)μg/L vs (187.80±35.47)μg/L,P=0.014;(4.01±1.52)g/L vs (3.55±1.26)g/L,P=0.012]。ROC曲线分析显示,ABCD3-I评分联合sCD40L、ABCD3-I评分联合Fib、ABCD3-I评分联合sCD40L和Fib预测TIA患者90d内发展为脑梗死的曲线下面积分别为0.656(95%CI:0.586~0.732,P=0.001)、0.680(95%CI:0.615~0.745,P=0.000)和0.714(95%CI:0.654~0.774,P=0.000),均有预测价值,且ABCD3-I评分联合sCD40L和Fib的预测价值较前两者更高,其敏感性为90.1%,特异性为88.2%。结论 ABCD3-I评分联合sCD40L和Fib检测可进一步提高预测TIA患者90d内发展为脑梗死的准确率,且预测价值较高。
