目的评估120 k V门静脉期图像结合碘图对急性胰腺炎早期坏死灶的诊断价值。方法前瞻性纳入2014年5月至2014年8月期间在四川大学华西医院住院治疗的、发病72 h以内的急性胰腺炎患者共17例,经双源CT双能量扫描技术获得120 k V门静脉期图...目的评估120 k V门静脉期图像结合碘图对急性胰腺炎早期坏死灶的诊断价值。方法前瞻性纳入2014年5月至2014年8月期间在四川大学华西医院住院治疗的、发病72 h以内的急性胰腺炎患者共17例,经双源CT双能量扫描技术获得120 k V门静脉期图像和碘图图像,比较单纯120 k V门静脉期图像和120 k V门静脉期图像+碘图对急性胰腺炎早期坏死灶的诊断价值。结果 17例患者中,6例患者存在胰腺坏死,其中4例早期未发现确切坏死灶者进展为坏死,而2例早期发现坏死灶患者经随访已好转;余11例无胰腺坏死灶。120 k V门静脉期图像诊断急性胰腺炎早期坏死灶的灵敏度为50.0%(3/6),特异度为100%(11/11),准确性为82.4%(14/17),具有一定的诊断价值(AUC=0.856,P=0.018);120 k V门静脉期图像+碘图诊断急性胰腺炎早期坏死灶的的灵敏度为100%(6/6),特异度为90.9%(10/11),准确性为94.1%(16/17),具有较高的诊断价值(AUC=0.977,P=0.002),且高于120 k V门静脉期图像的AUC值(P=0.002)。结论 120 k V门静脉期图像结合碘图能提高对急性胰腺炎早期坏死灶的主观判断能力,还能敏感地显示胰腺实质缺血区域,具有较高的临床诊断价值。展开更多
目的探讨能谱CT单能量图、碘图及融合图在乳腺癌中的诊断价值,并定量分析病灶与正常腺体之间CT值、碘浓度的差异。方法回顾性分析采用能谱方法扫描的乳腺癌患者21例,同时分析21例健康人的乳腺作为对照组。利用工作站后处理功能,分析单...目的探讨能谱CT单能量图、碘图及融合图在乳腺癌中的诊断价值,并定量分析病灶与正常腺体之间CT值、碘浓度的差异。方法回顾性分析采用能谱方法扫描的乳腺癌患者21例,同时分析21例健康人的乳腺作为对照组。利用工作站后处理功能,分析单能量图、碘图及混合能量图对肿块的显示情况,测量乳腺病灶和正常腺体CT值、碘浓度,定量分析病灶与正常腺体之间CT值、碘浓度的差异并进行统计学分析。结果21例乳腺癌病灶在能谱CT的单能量图、碘图及融合图上均能清楚的显示。病灶在55 keV单能量图的增强CT值明显高于混合能量图(70.65 HU vs 44.95 HU,P<0.001);病灶碘浓度明显高于健康对照组(1.69 mg/ml vs 0.36 mg/ml,P<0.001)。结论能谱CT的多参数图像能清楚的显示乳腺癌病灶,碘摄取值作为能谱CT的定量参数,在乳腺癌的诊断中具有较高的价值。展开更多
BACKGROUND Although surgery remains the primary treatment for gastric cancer(GC),the identification of effective alternative treatments for individuals for whom surgery is unsuitable holds significance.HER2 overexpres...BACKGROUND Although surgery remains the primary treatment for gastric cancer(GC),the identification of effective alternative treatments for individuals for whom surgery is unsuitable holds significance.HER2 overexpression occurs in approximately 15%-20%of advanced GC cases,directly affecting treatment-related decisions.Spectral-computed tomography(sCT)enables the quantification of material compositions,and sCT iodine concentration parameters have been demonstrated to be useful for the diagnosis of GC and prediction of its invasion depth,angioge-nesis,and response to systemic chemotherapy.No existing report describes the prediction of GC HER2 status through histogram analysis based on sCT iodine maps(IMs).AIM To investigate whether whole-volume histogram analysis of sCT IMs enables the prediction of the GC HER2 status.METHODS This study was performed with data from 101 patients with pathologically confirmed GC who underwent preoperative sCT examinations.Nineteen parameters were extracted via sCT IM histogram analysis:The minimum,maximum,mean,standard deviation,variance,coefficient of variation,skewness,kurtosis,entropy,percentiles(1st,5th,10th,25th,50th,75th,90th,95th,and 99th),and lesion volume.Spearman correlations of the parameters with the HER2 status and clinicopathological parameters were assessed.Receiver operating characteristic curves were used to evaluate the parameters’diagnostic performance.RESULTS Values for the histogram parameters of the maximum,mean,standard deviation,variance,entropy,and percentiles were significantly lower in the HER2+group than in the HER2–group(all P<0.05).The GC differentiation and Lauren classification correlated significantly with the HER2 status of tumor tissue(P=0.001 and 0.023,respectively).The 99th percentile had the largest area under the curve for GC HER2 status identification(0.740),with 76.2%,sensitivity,65.0%specificity,and 67.3%accuracy.All sCT IM histogram parameters correlated positively with the GC HER2 status(r=0.237-0.337,P=0.001-0.017).CONCLUSION Whole-le展开更多
文摘目的评估120 k V门静脉期图像结合碘图对急性胰腺炎早期坏死灶的诊断价值。方法前瞻性纳入2014年5月至2014年8月期间在四川大学华西医院住院治疗的、发病72 h以内的急性胰腺炎患者共17例,经双源CT双能量扫描技术获得120 k V门静脉期图像和碘图图像,比较单纯120 k V门静脉期图像和120 k V门静脉期图像+碘图对急性胰腺炎早期坏死灶的诊断价值。结果 17例患者中,6例患者存在胰腺坏死,其中4例早期未发现确切坏死灶者进展为坏死,而2例早期发现坏死灶患者经随访已好转;余11例无胰腺坏死灶。120 k V门静脉期图像诊断急性胰腺炎早期坏死灶的灵敏度为50.0%(3/6),特异度为100%(11/11),准确性为82.4%(14/17),具有一定的诊断价值(AUC=0.856,P=0.018);120 k V门静脉期图像+碘图诊断急性胰腺炎早期坏死灶的的灵敏度为100%(6/6),特异度为90.9%(10/11),准确性为94.1%(16/17),具有较高的诊断价值(AUC=0.977,P=0.002),且高于120 k V门静脉期图像的AUC值(P=0.002)。结论 120 k V门静脉期图像结合碘图能提高对急性胰腺炎早期坏死灶的主观判断能力,还能敏感地显示胰腺实质缺血区域,具有较高的临床诊断价值。
文摘目的探讨能谱CT单能量图、碘图及融合图在乳腺癌中的诊断价值,并定量分析病灶与正常腺体之间CT值、碘浓度的差异。方法回顾性分析采用能谱方法扫描的乳腺癌患者21例,同时分析21例健康人的乳腺作为对照组。利用工作站后处理功能,分析单能量图、碘图及混合能量图对肿块的显示情况,测量乳腺病灶和正常腺体CT值、碘浓度,定量分析病灶与正常腺体之间CT值、碘浓度的差异并进行统计学分析。结果21例乳腺癌病灶在能谱CT的单能量图、碘图及融合图上均能清楚的显示。病灶在55 keV单能量图的增强CT值明显高于混合能量图(70.65 HU vs 44.95 HU,P<0.001);病灶碘浓度明显高于健康对照组(1.69 mg/ml vs 0.36 mg/ml,P<0.001)。结论能谱CT的多参数图像能清楚的显示乳腺癌病灶,碘摄取值作为能谱CT的定量参数,在乳腺癌的诊断中具有较高的价值。
基金Supported by Science and Technology Program of Fujian Province,No.2021J01430Joint Funds for the Innovation of Science and Technology of Fujian Province,No.2021Y9229.
文摘BACKGROUND Although surgery remains the primary treatment for gastric cancer(GC),the identification of effective alternative treatments for individuals for whom surgery is unsuitable holds significance.HER2 overexpression occurs in approximately 15%-20%of advanced GC cases,directly affecting treatment-related decisions.Spectral-computed tomography(sCT)enables the quantification of material compositions,and sCT iodine concentration parameters have been demonstrated to be useful for the diagnosis of GC and prediction of its invasion depth,angioge-nesis,and response to systemic chemotherapy.No existing report describes the prediction of GC HER2 status through histogram analysis based on sCT iodine maps(IMs).AIM To investigate whether whole-volume histogram analysis of sCT IMs enables the prediction of the GC HER2 status.METHODS This study was performed with data from 101 patients with pathologically confirmed GC who underwent preoperative sCT examinations.Nineteen parameters were extracted via sCT IM histogram analysis:The minimum,maximum,mean,standard deviation,variance,coefficient of variation,skewness,kurtosis,entropy,percentiles(1st,5th,10th,25th,50th,75th,90th,95th,and 99th),and lesion volume.Spearman correlations of the parameters with the HER2 status and clinicopathological parameters were assessed.Receiver operating characteristic curves were used to evaluate the parameters’diagnostic performance.RESULTS Values for the histogram parameters of the maximum,mean,standard deviation,variance,entropy,and percentiles were significantly lower in the HER2+group than in the HER2–group(all P<0.05).The GC differentiation and Lauren classification correlated significantly with the HER2 status of tumor tissue(P=0.001 and 0.023,respectively).The 99th percentile had the largest area under the curve for GC HER2 status identification(0.740),with 76.2%,sensitivity,65.0%specificity,and 67.3%accuracy.All sCT IM histogram parameters correlated positively with the GC HER2 status(r=0.237-0.337,P=0.001-0.017).CONCLUSION Whole-le
