<strong>Objective</strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"><strong>: </strong>Since the...<strong>Objective</strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"><strong>: </strong>Since the identification of COVID-19 in December 2019 as a pandemic, over 4500 research papers were published with the term “COVID-19” contained in its title. Many of these reports on the COVID-19 pandemic suggested that the coronavirus was associated with more serious chronic diseases and mortality particularly in patients with chronic diseases regardless of country and age. Therefore, there is a need to understand how common comorbidities and other factors are associated with the risk of death due to COVID-19 infection. Our investigation aims at exploring this relationship. Specifically, our analysis aimed to explore the relationship between the total number of COVID-19 cases and mortality associated with COVID-19 infection accounting for other risk factors. </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: Due to the presence of over dispersion, the Negative Binomial Regression is used to model the aggregate number of COVID-19 cases. Case-fatality associated with this infection is modeled as an outcome variable using machine learning predictive multivariable regression. The data we used are the COVID-19 cases and associated deaths from the start of the pandemic up to December 02-2020, the day Pfizer was granted approval for their new COVID-19 vaccine. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: Our analysis found significant regional variation in case fatality. Moreover, the aggregate number of cases had several risk factors including chronic kidney disease, population density and the percentage of gross domestic product spent on healthcare. </span><b><span style="font-family:Verdana;">The Conclusions</span></b><span style="font-family:Verdana;">: There are important regional variations in COVID-19 case fatality. We identified three factors to be significantly correlated with cas展开更多
文摘<strong>Objective</strong><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"><strong>: </strong>Since the identification of COVID-19 in December 2019 as a pandemic, over 4500 research papers were published with the term “COVID-19” contained in its title. Many of these reports on the COVID-19 pandemic suggested that the coronavirus was associated with more serious chronic diseases and mortality particularly in patients with chronic diseases regardless of country and age. Therefore, there is a need to understand how common comorbidities and other factors are associated with the risk of death due to COVID-19 infection. Our investigation aims at exploring this relationship. Specifically, our analysis aimed to explore the relationship between the total number of COVID-19 cases and mortality associated with COVID-19 infection accounting for other risk factors. </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: Due to the presence of over dispersion, the Negative Binomial Regression is used to model the aggregate number of COVID-19 cases. Case-fatality associated with this infection is modeled as an outcome variable using machine learning predictive multivariable regression. The data we used are the COVID-19 cases and associated deaths from the start of the pandemic up to December 02-2020, the day Pfizer was granted approval for their new COVID-19 vaccine. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: Our analysis found significant regional variation in case fatality. Moreover, the aggregate number of cases had several risk factors including chronic kidney disease, population density and the percentage of gross domestic product spent on healthcare. </span><b><span style="font-family:Verdana;">The Conclusions</span></b><span style="font-family:Verdana;">: There are important regional variations in COVID-19 case fatality. We identified three factors to be significantly correlated with cas
