The concept of fecal microbiota transplantation(FMT)has been used in traditional Chinese medicine at least since the 4thcentury.Evidence from recent human studies strongly supports the link between intestinal bacteria...The concept of fecal microbiota transplantation(FMT)has been used in traditional Chinese medicine at least since the 4thcentury.Evidence from recent human studies strongly supports the link between intestinal bacteria and inflammatory bowel disease.We proposed that standardized FMT might be a promising rescue therapy for refractory inflammatory bowel disease.However,there were no reports of FMT used in patients with severe Crohn’s disease(CD).Here,we report the successful treatment of standardized FMT as a rescue therapy for a case of refractory CD complicated with fistula,residual Barium sulfate and formation of intraperitoneal large inflammatory mass.As far as we know,this is the first case of severe CD treated using FMT through mid-gut.展开更多
Inflammatory bowel diseases(IBD),including Crohn's disease and ulcerative colitis,are complex diseases that result from the chronic dysregulated immune response in the gastrointestinal tract. The exact etiology is...Inflammatory bowel diseases(IBD),including Crohn's disease and ulcerative colitis,are complex diseases that result from the chronic dysregulated immune response in the gastrointestinal tract. The exact etiology is not fully understood,but it is accepted that it occurs when an inappropriate aggressive inflammatory respon-se in a genetically susceptible host due to inciting environmental factors occurs. To investigate the path-ogenesis and etiology of human IBD,various animal models of IBD have been developed that provided indispensable insights into the histopathological and morphological changes as well as factors associated with the pathogenesis of IBD and evaluation of therapeutic options in the last few decades. The most widely used experimental model employs dextran sodium sulfate(DSS) to induce epithelial damage. The DSS colitis model in IBD research has advantages over other various chemically induced experimental models due to its rapidity,simplicity,reproducibility and controllability. In this manuscript,we review the newer publicized advances of research in murine colitis models that focus upon the disruption of the barrier function of the intestine,effects of mucin on the development of colitis,alterations found in microbial balance and resultant changes in the metabolome specifically in the DSS colitis murine model and its relation to the pathogenesis of IBD.展开更多
Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nucl...Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, harrier function and prevention of bacterial manslocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide, range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles of FXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved展开更多
目的了解炎症性肠病患者对疾病相关知识的掌握情况和对健康教育的需求，为针对性的健康指导提供依据。方法采用中文版克罗恩病与溃疡性结肠炎知识问卷（Crohn＇s and Colitis Knowledge Score,CCKNOW）对106例炎症性肠病患者进行问卷调...目的了解炎症性肠病患者对疾病相关知识的掌握情况和对健康教育的需求，为针对性的健康指导提供依据。方法采用中文版克罗恩病与溃疡性结肠炎知识问卷（Crohn＇s and Colitis Knowledge Score,CCKNOW）对106例炎症性肠病患者进行问卷调查.结果炎症性肠病患者CCKNOW总分为（5．82±4．66）分；其中78例溃疡性结肠炎患者为（5．42±4．44）分，28例克罗恩病患者为（6．61±4．92）分，差异无统计学意义（P〉0．05）。问巷4个维度的问题回答正确率分别为：饮食知识32％～39％，药物知识27％-36％，一般知识22％～28％，并发症知识20％～21％.患者的文化程度和病程是其知识水平的主要影响因素；97．2％的患者对药物和非药物治疗知识有较高需求，90．6％的患者对并发症知识需求强烈;患者疾病知识来源主要是医务人员。结论炎症性肠病患者疾病相关知识知晓率总体水平较低，对药物、非药物治疗知识和并发症方面知识有较高需求。护理人员应根据炎症性肠病患者对疾病知识的掌握程度、不同文化程度和健康教育的不同需求，给予针对性的健康指导，从而促进炎症性肠病患者的健康行为，提高其生活质量．展开更多
基金Supported by(in part)The Public Donated Grant "Intestine Initiative"
文摘The concept of fecal microbiota transplantation(FMT)has been used in traditional Chinese medicine at least since the 4thcentury.Evidence from recent human studies strongly supports the link between intestinal bacteria and inflammatory bowel disease.We proposed that standardized FMT might be a promising rescue therapy for refractory inflammatory bowel disease.However,there were no reports of FMT used in patients with severe Crohn’s disease(CD).Here,we report the successful treatment of standardized FMT as a rescue therapy for a case of refractory CD complicated with fistula,residual Barium sulfate and formation of intraperitoneal large inflammatory mass.As far as we know,this is the first case of severe CD treated using FMT through mid-gut.
基金Supported by the Department of Veterans Affairs,Office of Research and Development(Biomedical Laboratory Research and Development)No.BX001155
文摘Inflammatory bowel diseases(IBD),including Crohn's disease and ulcerative colitis,are complex diseases that result from the chronic dysregulated immune response in the gastrointestinal tract. The exact etiology is not fully understood,but it is accepted that it occurs when an inappropriate aggressive inflammatory respon-se in a genetically susceptible host due to inciting environmental factors occurs. To investigate the path-ogenesis and etiology of human IBD,various animal models of IBD have been developed that provided indispensable insights into the histopathological and morphological changes as well as factors associated with the pathogenesis of IBD and evaluation of therapeutic options in the last few decades. The most widely used experimental model employs dextran sodium sulfate(DSS) to induce epithelial damage. The DSS colitis model in IBD research has advantages over other various chemically induced experimental models due to its rapidity,simplicity,reproducibility and controllability. In this manuscript,we review the newer publicized advances of research in murine colitis models that focus upon the disruption of the barrier function of the intestine,effects of mucin on the development of colitis,alterations found in microbial balance and resultant changes in the metabolome specifically in the DSS colitis murine model and its relation to the pathogenesis of IBD.
基金supported by National Cancer Institute of United States (No.1R01-CA139158,to Wendong Huang)National Natural Science Foundation of China (Nos.81303186 and ZYX-NSFC-016)China Postdoctoral Science Foundation (No.2013M531202)
文摘Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, harrier function and prevention of bacterial manslocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide, range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles of FXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved
文摘目的了解炎症性肠病患者对疾病相关知识的掌握情况和对健康教育的需求，为针对性的健康指导提供依据。方法采用中文版克罗恩病与溃疡性结肠炎知识问卷（Crohn＇s and Colitis Knowledge Score,CCKNOW）对106例炎症性肠病患者进行问卷调查.结果炎症性肠病患者CCKNOW总分为（5．82±4．66）分；其中78例溃疡性结肠炎患者为（5．42±4．44）分，28例克罗恩病患者为（6．61±4．92）分，差异无统计学意义（P〉0．05）。问巷4个维度的问题回答正确率分别为：饮食知识32％～39％，药物知识27％-36％，一般知识22％～28％，并发症知识20％～21％.患者的文化程度和病程是其知识水平的主要影响因素；97．2％的患者对药物和非药物治疗知识有较高需求，90．6％的患者对并发症知识需求强烈;患者疾病知识来源主要是医务人员。结论炎症性肠病患者疾病相关知识知晓率总体水平较低，对药物、非药物治疗知识和并发症方面知识有较高需求。护理人员应根据炎症性肠病患者对疾病知识的掌握程度、不同文化程度和健康教育的不同需求，给予针对性的健康指导，从而促进炎症性肠病患者的健康行为，提高其生活质量．
