快速延迟整流钾电流(rapidly activating com ponent of delayed rectifier potassium current,IKr)在心肌动作电位复极化过程中发挥重要作用。HERG基因编码心脏快速延迟整流钾通道的α亚基,HERG基因突变导致遗传性长QT间期综合征(long ...快速延迟整流钾电流(rapidly activating com ponent of delayed rectifier potassium current,IKr)在心肌动作电位复极化过程中发挥重要作用。HERG基因编码心脏快速延迟整流钾通道的α亚基,HERG基因突变导致遗传性长QT间期综合征(long QT syndrome,LQTS),另外IKr/HERG通道是绝大多数能引起心脏QT间期延长药物的作用靶标,其他一些化学结构不同的药物也可阻断该通道,引起QT间期延长,甚至发展成获得性心律失常。本文从门控机制及功能、HERG通道相关的心律失常、药物与通道相互作用机制、优化通道靶点的策略等四个方面综述IKr/HERG通道在抗心律失常方面的最新研究进展。展开更多
最近研究表明hERG(human ether-a—go-go related gene)基因编码的钾离子通道(hERG通道)作为一种广谱的药物靶标,被某些药物作用时会引起长QT间期综合征(LQTS),甚至导致具有生命危险的室性心律失常——尖端扭转性室性心动过速(TdP),引...最近研究表明hERG(human ether-a—go-go related gene)基因编码的钾离子通道(hERG通道)作为一种广谱的药物靶标,被某些药物作用时会引起长QT间期综合征(LQTS),甚至导致具有生命危险的室性心律失常——尖端扭转性室性心动过速(TdP),引起制药公司和安全部门的广泛关注,现就hERG通道的结构和功能特征、不同亚基及细胞环境对其调节、目前临床前体内体外的研究方法及关于hERG通道的药物安全性评价进行简要介绍。展开更多
Although the deuterium and helium have almost the same mass,a Penning Optical Gas Analyzer（POGA） system on the basis of the spectroscopic method and Penning discharging has been designed on EAST,since 2014.The POGA ...Although the deuterium and helium have almost the same mass,a Penning Optical Gas Analyzer（POGA） system on the basis of the spectroscopic method and Penning discharging has been designed on EAST,since 2014.The POGA system was developed successfully in 2015,it was the first time that EAST could detect helium partial pressure in deuterium plasma（wall conditioning and plasma operation scenario）.With dedicated calibration and proper adjustment of the parameters,the minimum concentration of helium in deuterium gas can be measured as about 0.5% instead of 1% on the other tokamak devices.Moreover,the He and D2 partial pressures are measured simultaneously.At present,the measurable range of deuterium partial pressure is 1×10^-7 mbar to 1×10^-5mbar,meanwhile the range of helium is 1×10^-8 mbar to 1×10^-5 mbar.The measurable range can be modified by means of the adjustment of POGA system＇s parameters.It is possible to detect the interesting part of the gas with a time resolution of less than 5 ms（the 200 ms because of conductance of transfer pipe at present）.The POGA system was routinely employed to wall conditioning and helium enrichment investigation in2015.Last but not the least,the low temperature plasma of POGA is generated by normal penning gauge Pfeiffer IKR gauge instead of Alcatel CF2 P,which has been suspended for a few years and was used for almost all the POGA systems in the world.展开更多
文摘最近研究表明hERG(human ether-a—go-go related gene)基因编码的钾离子通道(hERG通道)作为一种广谱的药物靶标,被某些药物作用时会引起长QT间期综合征(LQTS),甚至导致具有生命危险的室性心律失常——尖端扭转性室性心动过速(TdP),引起制药公司和安全部门的广泛关注,现就hERG通道的结构和功能特征、不同亚基及细胞环境对其调节、目前临床前体内体外的研究方法及关于hERG通道的药物安全性评价进行简要介绍。
基金funded by National Magnetic Confinement Fusion Science Program of China under Contract No.2013GB114004,No.2014GB106005 & No.2015GB101000National Nature Science Foundation of China under Contract No.11625524,No.11321092 and No.11405210partly supported by the Japan Society for the Promotion of ScienceNational Research Foundation of Korea-National Science Foundation of China(JSPS-NRF-NSFC) A3 Foresight Program in the field of Plasma Physics(NSFC No.11261140328)
文摘Although the deuterium and helium have almost the same mass,a Penning Optical Gas Analyzer（POGA） system on the basis of the spectroscopic method and Penning discharging has been designed on EAST,since 2014.The POGA system was developed successfully in 2015,it was the first time that EAST could detect helium partial pressure in deuterium plasma（wall conditioning and plasma operation scenario）.With dedicated calibration and proper adjustment of the parameters,the minimum concentration of helium in deuterium gas can be measured as about 0.5% instead of 1% on the other tokamak devices.Moreover,the He and D2 partial pressures are measured simultaneously.At present,the measurable range of deuterium partial pressure is 1×10^-7 mbar to 1×10^-5mbar,meanwhile the range of helium is 1×10^-8 mbar to 1×10^-5 mbar.The measurable range can be modified by means of the adjustment of POGA system＇s parameters.It is possible to detect the interesting part of the gas with a time resolution of less than 5 ms（the 200 ms because of conductance of transfer pipe at present）.The POGA system was routinely employed to wall conditioning and helium enrichment investigation in2015.Last but not the least,the low temperature plasma of POGA is generated by normal penning gauge Pfeiffer IKR gauge instead of Alcatel CF2 P,which has been suspended for a few years and was used for almost all the POGA systems in the world.
