The problems of robust I2-I∞ and H∞ filtering for discrete-time systems with parameter uncertainty residing in a polytope are investigated in this paper. The filtering strategies are based on new robust performance ...The problems of robust I2-I∞ and H∞ filtering for discrete-time systems with parameter uncertainty residing in a polytope are investigated in this paper. The filtering strategies are based on new robust performance criteria derived from a new result of parameter-dependent Lyapunov stability condition, which exhibit less conservativeness than previous results in the quadratic framework. The designed filters guaranteeing a prescribed I2-I∞ or H∞ noise attenuation level can be obtained from the solution of convex optimization problems, which can be solved via efficient interior point methods. Numerical examples have shown that the filter design procedures proposed in this paper are much less conservative than earlier results.展开更多
5月27日,在2014浪潮创新数据中心全国巡展济南站,浪潮首度公布一项市场计划——IBM to Inspur(简称I2I计划),志在全面抢夺IBM X业务,加速推进服务器中国NO.1目标达成。在斯诺登事件发生之后,国内信息安全的政策、舆论环境都在向国产品...5月27日,在2014浪潮创新数据中心全国巡展济南站,浪潮首度公布一项市场计划——IBM to Inspur(简称I2I计划),志在全面抢夺IBM X业务,加速推进服务器中国NO.1目标达成。在斯诺登事件发生之后,国内信息安全的政策、舆论环境都在向国产品牌倾斜,国产化的春天已经到来。国外品牌开始在关键行业用户受到抵制,造就了国内信息产业"国进外退"的新市场格局,包括IBM、思科在内的国外品牌销量大幅下降。展开更多
Anti-β2 glycoprotein I （anti-β2GP I） antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome （APS）. However, the mechanism by which anti-β2GP I antibodies are ...Anti-β2 glycoprotein I （anti-β2GP I） antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome （APS）. However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti- β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2＇ （apoER2＇） and glycoprotein I ba （GP I bα） in platelet activation induced by the anti-β2GP I/β2GP I complex. The interaction between the anti-β2GP I/β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/III a activation and F-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GPI/β2GPI complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2＇ inhibitor. Results showed that the anti-β2GPI/β2GPl complex induced platelet activation via GP I bα and apoER2＇, which may then contribute to the prothrombotic tendency in APS patients.展开更多
In this paper, we present a new form of “special relativity” (BSR), which is isomorphic to Einstein’s “special relativity” (ESR). This in turn proves the non-uniqueness of Einstein’s “special relativity” and i...In this paper, we present a new form of “special relativity” (BSR), which is isomorphic to Einstein’s “special relativity” (ESR). This in turn proves the non-uniqueness of Einstein’s “special relativity” and implies the inconclusiveness of so-called “relativistic physics”. This work presents new results of principal significance for the foundations of physics and practical results for high energy physics, deep space astrophysics, and cosmology as well. The entire exposition is done within the formalism of the Lorentz <em>SL</em>(2<em>C</em>) group acting via isometries on <strong>real 3-dimensional Lobachevskian (hyperbolic) spaces</strong> <em>L</em><sup>3</sup> regarded as quotients <span style="white-space:nowrap;"><em>SL</em>(2<em>C</em>)/<em>SU</em>(2)</span>. We show via direct calculations that both ESR and BSR are parametric maps from Lobachevskian into Euclidean space, namely a <strong>gnomonic</strong> (central) map in the case of ESR, and a<strong> stereographic </strong>map in the case of BSR. Such an identification allows us to link these maps to relevant models of Lobachevskian geometry. Thus, we identify ESR as the physical realization of the Beltrami-Klein (non-conformal) model, and BSR as the physical realization of the Poincare (conformal) model of Lobachevskian geometry. Although we focus our discussion on ball models of Lobachevskian geometry, our method is quite general, and for instance, may be applied to the half-space model of Lobachevskian geometry with appropriate “Lorentz group” acting via isometries on (positive) half space, resulting yet in another “special relativity” isomorphic with ESR and BSR. By using the notion of a<strong> homotopy</strong> of maps, the identification of “special relativities” as maps from Lobachevskian into Euclidean space allows us to justify the existence of an uncountable infinity of hybrid “special relativities” and consequently an uncountable infinity of “relativistic physics” built upon them. This is another new re展开更多
<p align="justify"> <span style="font-family:Verdana;"></span><span style="font-family:Verdana;"></span>Myeloproliferative neoplasms (MPNs) are a group of cl...<p align="justify"> <span style="font-family:Verdana;"></span><span style="font-family:Verdana;"></span>Myeloproliferative neoplasms (MPNs) are a group of clonal haematopoietic stem cell disorders characterized by the proliferation of one or more myeloid cell lineages. According to WHO classification, the Janus associated kinase 2 (<em>JAK</em>2) V617F mutation is one of the major diagnostic criteria in BCR-ABL1 negative myeloproliferative neoplasms. The aim of this study is to detect the <em>JAK</em>2 (V617F) mutation in patients with myeloproliferative neoplasms to get accurate diagnosis and proper management. A total of 90 clinically diagnosed MPN patients attending to Department of Clinical Haematology, Yangon General Hospital were enrolled in this study. The mean age was 53.4 ± 14 years which ranged from 16 to 81 years old and male and female ratio was 2.4:1. The identification of <em>JAK</em>2 (V617F) point mutation was found to be positive in 44/90 MPN patients (48.9%). According to MPN subtypes, the <em>JAK</em>2 mutation positivity was found in 19 out of 46 polycythemia vera patients (41.3%), 17 out of 25 essential thrombocythemia patients (68%), 8 out of 15 primary myelofibrosis patients (53.3%), 0 of 4 others myeloproliferative neoplasms (0%). Confirmation of each of nine <em>JAK</em>2 mutation positive and negative samples was done by Sanger sequencing. The arterial or venous thrombotic attack was found in 32/44 <em>JAK</em>2 mutation positive cases (72.7%) and 12/44 <em>JAK</em>2 mutation negative cases (27.3%). The association between thrombotic attack and presence of <em>JAK</em>2 mutation was statistically significance with p = 0.000. The diagnosis of myeloproliferative neoplasms mainly relies on the molecular genetics according to WHO classification. The Allele specific PCR reaction is sensitive, simple test and relatively cost-effective. Therefore, the identification of <em>JAK</em>2 (V617F) somatic point mutation by AS-PCR should be implemented as a routine diagnosis procedure for patients wit展开更多
An economically-important trait in poultry for which gene identification <span style="font-family:Verdana;">continues to be a challenge is immune response. The objective of the study </span><s...An economically-important trait in poultry for which gene identification <span style="font-family:Verdana;">continues to be a challenge is immune response. The objective of the study </span><span style="font-family:Verdana;">was</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">to quantitate the expression of major histocompatibility complex (MHC) class II <i></i></span><i><i><span style="font-family:Verdana;">BLB2</span></i><span style="font-family:Verdana;"></span></i> gene at cytolytic and latent immune response stages in Nigerian indigenous chickens. </span><span style="font-family:Verdana;">A total of 108 Nigerian indigenous chickens (NIC) were sourced across the South-western states in Nigeria. The birds were inoculated with sheep red blood cells (SRBC), after which blood samples were obtained (5 days post-inoculation) and antibody haemagglutination test was carried out to place the birds into groups of high and low antibody titre levels.</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">The categorisation of the birds resulted in six groups of normal feather high, normal feather low, naked neck high, naked neck low, frizzle feather high and frizzle feather low antibody groups. </span><span style="font-family:Verdana;">A total of 48 chicks w</span></span><span style="font-family:Verdana;">ere</span><span style="font-family:Verdana;"> selected from the progeny for gene expression studies. </span><span style="font-family:Verdana;">Surgical excision of thymus and spleen was carried out for the detection of cytolytic and latent responses of the birds. β-actin was used as the endogenous control and the critical threshold method</span><span> </span><span style="font-family:Verdana;">(2<span style="white-space:nowrap;"><sup></sup></span><sup></sup></span><span style="font-family:;" "=""><span style="font-family:Verdana;"><sup>–ΔΔCт</sup><span style="white-space:nowrap;"></span>) w展开更多
In this work, we have analyzed the genetic variation that can alter the expression and the function in BRCA2 gene using computational methods. Out of the total 534 SNPs, 101 were found to be non synonymous (nsSNPs). A...In this work, we have analyzed the genetic variation that can alter the expression and the function in BRCA2 gene using computational methods. Out of the total 534 SNPs, 101 were found to be non synonymous (nsSNPs). Among the 7 SNPs in the untranslated region, 3 SNPs were found in 5′ and 4 SNPs were found in 3′ un-translated regions (UTR). Of the nsSNPs 20.7% were found to be damaging by both SIFT and PolyPhen server among the 101 nsSNPs investigated. UTR resource tool suggested that 2 SNPs in the 5′ UTR region and 4 SNPs in the 3′ UTR regions might change the protein expression levels. The mutation from asparagine to isoleucine at the position 3124 of the native protein of BRCA2 gene was most deleterious by both SIFT and PolyPhen servers. A structural analysis of this mutated protein and the native protein was made which had an RMSD value of 0.301 nm. Based on this work, we proposed that this most deleterious nsSNP with an SNPid rs28897759 is an important candidate for the cause of breast cancer by BRCA2 gene.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.69874008).
文摘The problems of robust I2-I∞ and H∞ filtering for discrete-time systems with parameter uncertainty residing in a polytope are investigated in this paper. The filtering strategies are based on new robust performance criteria derived from a new result of parameter-dependent Lyapunov stability condition, which exhibit less conservativeness than previous results in the quadratic framework. The designed filters guaranteeing a prescribed I2-I∞ or H∞ noise attenuation level can be obtained from the solution of convex optimization problems, which can be solved via efficient interior point methods. Numerical examples have shown that the filter design procedures proposed in this paper are much less conservative than earlier results.
文摘5月27日,在2014浪潮创新数据中心全国巡展济南站,浪潮首度公布一项市场计划——IBM to Inspur(简称I2I计划),志在全面抢夺IBM X业务,加速推进服务器中国NO.1目标达成。在斯诺登事件发生之后,国内信息安全的政策、舆论环境都在向国产品牌倾斜,国产化的春天已经到来。国外品牌开始在关键行业用户受到抵制,造就了国内信息产业"国进外退"的新市场格局,包括IBM、思科在内的国外品牌销量大幅下降。
基金This work was supported by the National Natural Science Foundation of China （No. 81270394） to Yanhong Liu. The authors would like to thank Xing Liu for providing expert technical assistance.
文摘Anti-β2 glycoprotein I （anti-β2GP I） antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome （APS）. However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti- β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2＇ （apoER2＇） and glycoprotein I ba （GP I bα） in platelet activation induced by the anti-β2GP I/β2GP I complex. The interaction between the anti-β2GP I/β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/III a activation and F-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GPI/β2GPI complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2＇ inhibitor. Results showed that the anti-β2GPI/β2GPl complex induced platelet activation via GP I bα and apoER2＇, which may then contribute to the prothrombotic tendency in APS patients.
文摘In this paper, we present a new form of “special relativity” (BSR), which is isomorphic to Einstein’s “special relativity” (ESR). This in turn proves the non-uniqueness of Einstein’s “special relativity” and implies the inconclusiveness of so-called “relativistic physics”. This work presents new results of principal significance for the foundations of physics and practical results for high energy physics, deep space astrophysics, and cosmology as well. The entire exposition is done within the formalism of the Lorentz <em>SL</em>(2<em>C</em>) group acting via isometries on <strong>real 3-dimensional Lobachevskian (hyperbolic) spaces</strong> <em>L</em><sup>3</sup> regarded as quotients <span style="white-space:nowrap;"><em>SL</em>(2<em>C</em>)/<em>SU</em>(2)</span>. We show via direct calculations that both ESR and BSR are parametric maps from Lobachevskian into Euclidean space, namely a <strong>gnomonic</strong> (central) map in the case of ESR, and a<strong> stereographic </strong>map in the case of BSR. Such an identification allows us to link these maps to relevant models of Lobachevskian geometry. Thus, we identify ESR as the physical realization of the Beltrami-Klein (non-conformal) model, and BSR as the physical realization of the Poincare (conformal) model of Lobachevskian geometry. Although we focus our discussion on ball models of Lobachevskian geometry, our method is quite general, and for instance, may be applied to the half-space model of Lobachevskian geometry with appropriate “Lorentz group” acting via isometries on (positive) half space, resulting yet in another “special relativity” isomorphic with ESR and BSR. By using the notion of a<strong> homotopy</strong> of maps, the identification of “special relativities” as maps from Lobachevskian into Euclidean space allows us to justify the existence of an uncountable infinity of hybrid “special relativities” and consequently an uncountable infinity of “relativistic physics” built upon them. This is another new re
文摘<p align="justify"> <span style="font-family:Verdana;"></span><span style="font-family:Verdana;"></span>Myeloproliferative neoplasms (MPNs) are a group of clonal haematopoietic stem cell disorders characterized by the proliferation of one or more myeloid cell lineages. According to WHO classification, the Janus associated kinase 2 (<em>JAK</em>2) V617F mutation is one of the major diagnostic criteria in BCR-ABL1 negative myeloproliferative neoplasms. The aim of this study is to detect the <em>JAK</em>2 (V617F) mutation in patients with myeloproliferative neoplasms to get accurate diagnosis and proper management. A total of 90 clinically diagnosed MPN patients attending to Department of Clinical Haematology, Yangon General Hospital were enrolled in this study. The mean age was 53.4 ± 14 years which ranged from 16 to 81 years old and male and female ratio was 2.4:1. The identification of <em>JAK</em>2 (V617F) point mutation was found to be positive in 44/90 MPN patients (48.9%). According to MPN subtypes, the <em>JAK</em>2 mutation positivity was found in 19 out of 46 polycythemia vera patients (41.3%), 17 out of 25 essential thrombocythemia patients (68%), 8 out of 15 primary myelofibrosis patients (53.3%), 0 of 4 others myeloproliferative neoplasms (0%). Confirmation of each of nine <em>JAK</em>2 mutation positive and negative samples was done by Sanger sequencing. The arterial or venous thrombotic attack was found in 32/44 <em>JAK</em>2 mutation positive cases (72.7%) and 12/44 <em>JAK</em>2 mutation negative cases (27.3%). The association between thrombotic attack and presence of <em>JAK</em>2 mutation was statistically significance with p = 0.000. The diagnosis of myeloproliferative neoplasms mainly relies on the molecular genetics according to WHO classification. The Allele specific PCR reaction is sensitive, simple test and relatively cost-effective. Therefore, the identification of <em>JAK</em>2 (V617F) somatic point mutation by AS-PCR should be implemented as a routine diagnosis procedure for patients wit
文摘An economically-important trait in poultry for which gene identification <span style="font-family:Verdana;">continues to be a challenge is immune response. The objective of the study </span><span style="font-family:Verdana;">was</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">to quantitate the expression of major histocompatibility complex (MHC) class II <i></i></span><i><i><span style="font-family:Verdana;">BLB2</span></i><span style="font-family:Verdana;"></span></i> gene at cytolytic and latent immune response stages in Nigerian indigenous chickens. </span><span style="font-family:Verdana;">A total of 108 Nigerian indigenous chickens (NIC) were sourced across the South-western states in Nigeria. The birds were inoculated with sheep red blood cells (SRBC), after which blood samples were obtained (5 days post-inoculation) and antibody haemagglutination test was carried out to place the birds into groups of high and low antibody titre levels.</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">The categorisation of the birds resulted in six groups of normal feather high, normal feather low, naked neck high, naked neck low, frizzle feather high and frizzle feather low antibody groups. </span><span style="font-family:Verdana;">A total of 48 chicks w</span></span><span style="font-family:Verdana;">ere</span><span style="font-family:Verdana;"> selected from the progeny for gene expression studies. </span><span style="font-family:Verdana;">Surgical excision of thymus and spleen was carried out for the detection of cytolytic and latent responses of the birds. β-actin was used as the endogenous control and the critical threshold method</span><span> </span><span style="font-family:Verdana;">(2<span style="white-space:nowrap;"><sup></sup></span><sup></sup></span><span style="font-family:;" "=""><span style="font-family:Verdana;"><sup>–ΔΔCт</sup><span style="white-space:nowrap;"></span>) w
文摘In this work, we have analyzed the genetic variation that can alter the expression and the function in BRCA2 gene using computational methods. Out of the total 534 SNPs, 101 were found to be non synonymous (nsSNPs). Among the 7 SNPs in the untranslated region, 3 SNPs were found in 5′ and 4 SNPs were found in 3′ un-translated regions (UTR). Of the nsSNPs 20.7% were found to be damaging by both SIFT and PolyPhen server among the 101 nsSNPs investigated. UTR resource tool suggested that 2 SNPs in the 5′ UTR region and 4 SNPs in the 3′ UTR regions might change the protein expression levels. The mutation from asparagine to isoleucine at the position 3124 of the native protein of BRCA2 gene was most deleterious by both SIFT and PolyPhen servers. A structural analysis of this mutated protein and the native protein was made which had an RMSD value of 0.301 nm. Based on this work, we proposed that this most deleterious nsSNP with an SNPid rs28897759 is an important candidate for the cause of breast cancer by BRCA2 gene.
