On the basis of compiled multidisciplinary historical data in 2006-2007 and incorporation of relevant simulation results and re- mote sensing data, we performed an in-depth study of the generation and dissipation proc...On the basis of compiled multidisciplinary historical data in 2006-2007 and incorporation of relevant simulation results and re- mote sensing data, we performed an in-depth study of the generation and dissipation process of the hypoxic zone and its distribu- tion morphology and structure off the Yangtze River estuary, Based on the hydrological circulation dynamics, reproduction of phytoplankton (leading to the decomposition of organic matter), and other factors, we comprehensively and systematically inves- tigated the generation and dissipation of the hypoxic zone and underlying mechanisms for the seasonal variation in its position, explored the multi-factorial synergistic reactions during the generation and dissipation process of the hypoxic zone, and revealed the controlled mechanism for the morphology and structure of the hypoxic zone's distribution. Our studies indicate that in the winter and spring seasons, the hydrological environment off the Yangtze River estuary provides a water body with relatively low contents of dissolved oxygen (DO), which is the background for the formation of a hypoxic zone. After entering into the summer season, the hypoxic zone gradually develops towards the north and becomes mature. Because of the impact of the terrain, local decomposition of organic matter, and upwelling of the Kuroshio subsurface water in July-August, the bypoxic zone off the Yang- tze River estuary exhibits the characteristics of discontinuous distribution in space and has a south and north "dual-core" structure in the inner continental shelf. In addition, there is a hypoxic core in the eastern outer continental shelf. The degrees of hypoxia vary for different areas; they are strongest overall in the north, next strongest in the south; they are weakest on the outer continen- tal shelf. In summer, the hypoxic zone in the north is related to the northward differentiation of the southern hypoxic zone and re- sults from local development and intensification. In August, the hypoxic zone in the north r展开更多
目的采用meta分析综合定量评价低氧环境对人体睡眠的影响,为高海拔低氧环境下睡眠研究提供理论基础。方法以'低氧睡眠'、'高海拔睡眠'、'高原睡眠'、'altitude and sleep'、'hypobaric hypoxia and...目的采用meta分析综合定量评价低氧环境对人体睡眠的影响,为高海拔低氧环境下睡眠研究提供理论基础。方法以'低氧睡眠'、'高海拔睡眠'、'高原睡眠'、'altitude and sleep'、'hypobaric hypoxia and sleep'、'normal hypoxia and sleep'、'polysomnography and altitude'等为检索词检索各数据库,并建立纳入和排除标准,采用Revman 5.3软件对所有纳入文献的结局指标进行统计分析。结果共纳入研究文献13篇,研究对象共210名成年人,其中男性168名,女性42名,每名受试者均进行了常氧和低氧两个环境下的睡眠监控。敏感性分析表明研究结果较稳定,漏斗图分析提示不存在明显的发表偏倚。meta分析结果显示,低氧环境对机体睡眠过程中的睡眠效率(合并效应值为-2.79,95%CI:-4.59^-1.00,P<0.01),慢波睡眠比例(合并效应值为-4.47,95%CI:-6.38^-2.57,P<0.01),血氧饱和度(合并效应值为-12.40,95%CI:-16.91^-7.89,P<0.01)均有明显影响,而对快速动眼期睡眠比例无明显影响(合并效应值为-1.99,95%CI:-5.94^-1.97,P>0.05)。结论低氧环境会导致成年人睡眠障碍,表现为有效睡眠时长缩短、睡眠深度比例降低。展开更多
Sonodynamic therapy(SDT)has attracted great interest in the field of cancer therapy because of its non-invasiveness,deep penetration,spatiotemporal controllability.However,the sonodynamic effect is severely hindered b...Sonodynamic therapy(SDT)has attracted great interest in the field of cancer therapy because of its non-invasiveness,deep penetration,spatiotemporal controllability.However,the sonodynamic effect is severely hindered by hypoxia and a high glutathione(GSH)level in tumor microenvironment.In this work,a new type of nanohybrid sonosensitizer is designed,which incorporates several prominent advantages of organic,inorganic,natural sonosensitizers for imaging-guided SDT and ferroptosis induction.As an endogenous transporter,hemoglobin(Hb)has dual functions of oxygen and iron supplement.Apparently,Hb can transport iron to the tumor site for Fe-dependent ferroptosis,yet this oxygen carrier is able to enhance the sensitivity of tumor cells to oxygen-driven SDT.We innovatively hybridized Hb,sinoporphyrin sodium(DVDMS),titanium dioxide(TiO_(2))to prepare an integrated nano-oxygen carrier(designated as HDT)for multifarious cancer theranostics,which not only attained satisfactory sonosensitization of DVDMS/TiO_(2)but also achieved oxygen-boosted SDT and potent ferroptosis via Hb.Under ultrasound irradiation,the oxygenation of HDT markedly amplified the generation of reactive oxygen species(ROS)in hypoxic tumors,promoted the valence transition of Hb to accelerate Fenton reaction,led to ferroptosis.This strategy virtually eradicated tumors in situ and exhibited immunoregulatory potential for augmenting anti-tumor effects in vivo and in vitro through ROS formation,O_(2)self-supplement,GSH depletion,lipid peroxidation.Collectively,HDT demonstrated excellent dual-modal imaging performance,providing a valuable platform for photoacoustic/fluorescence-guided SDT and ferroptosis induction in tumor cells.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.41206068)the National Ocean Public Welfare Scientific Research Project of China(Grant No.201105014)+2 种基金the National Basic Research Program of China(Grant Nos.2010CB429004,2010CB951900)the National Project of Comprehensive Survey and Assessment of the Coastal Seas of China(Grant No.908-ZC-I-03)the National Key Technology Research and Development Program of China(Grant No.2008BAC42B02)
文摘On the basis of compiled multidisciplinary historical data in 2006-2007 and incorporation of relevant simulation results and re- mote sensing data, we performed an in-depth study of the generation and dissipation process of the hypoxic zone and its distribu- tion morphology and structure off the Yangtze River estuary, Based on the hydrological circulation dynamics, reproduction of phytoplankton (leading to the decomposition of organic matter), and other factors, we comprehensively and systematically inves- tigated the generation and dissipation of the hypoxic zone and underlying mechanisms for the seasonal variation in its position, explored the multi-factorial synergistic reactions during the generation and dissipation process of the hypoxic zone, and revealed the controlled mechanism for the morphology and structure of the hypoxic zone's distribution. Our studies indicate that in the winter and spring seasons, the hydrological environment off the Yangtze River estuary provides a water body with relatively low contents of dissolved oxygen (DO), which is the background for the formation of a hypoxic zone. After entering into the summer season, the hypoxic zone gradually develops towards the north and becomes mature. Because of the impact of the terrain, local decomposition of organic matter, and upwelling of the Kuroshio subsurface water in July-August, the bypoxic zone off the Yang- tze River estuary exhibits the characteristics of discontinuous distribution in space and has a south and north "dual-core" structure in the inner continental shelf. In addition, there is a hypoxic core in the eastern outer continental shelf. The degrees of hypoxia vary for different areas; they are strongest overall in the north, next strongest in the south; they are weakest on the outer continen- tal shelf. In summer, the hypoxic zone in the north is related to the northward differentiation of the southern hypoxic zone and re- sults from local development and intensification. In August, the hypoxic zone in the north r
文摘目的采用meta分析综合定量评价低氧环境对人体睡眠的影响,为高海拔低氧环境下睡眠研究提供理论基础。方法以'低氧睡眠'、'高海拔睡眠'、'高原睡眠'、'altitude and sleep'、'hypobaric hypoxia and sleep'、'normal hypoxia and sleep'、'polysomnography and altitude'等为检索词检索各数据库,并建立纳入和排除标准,采用Revman 5.3软件对所有纳入文献的结局指标进行统计分析。结果共纳入研究文献13篇,研究对象共210名成年人,其中男性168名,女性42名,每名受试者均进行了常氧和低氧两个环境下的睡眠监控。敏感性分析表明研究结果较稳定,漏斗图分析提示不存在明显的发表偏倚。meta分析结果显示,低氧环境对机体睡眠过程中的睡眠效率(合并效应值为-2.79,95%CI:-4.59^-1.00,P<0.01),慢波睡眠比例(合并效应值为-4.47,95%CI:-6.38^-2.57,P<0.01),血氧饱和度(合并效应值为-12.40,95%CI:-16.91^-7.89,P<0.01)均有明显影响,而对快速动眼期睡眠比例无明显影响(合并效应值为-1.99,95%CI:-5.94^-1.97,P>0.05)。结论低氧环境会导致成年人睡眠障碍,表现为有效睡眠时长缩短、睡眠深度比例降低。
基金the Fundamental Research Funds for the Central Universities(No.GK202105004).
文摘Sonodynamic therapy(SDT)has attracted great interest in the field of cancer therapy because of its non-invasiveness,deep penetration,spatiotemporal controllability.However,the sonodynamic effect is severely hindered by hypoxia and a high glutathione(GSH)level in tumor microenvironment.In this work,a new type of nanohybrid sonosensitizer is designed,which incorporates several prominent advantages of organic,inorganic,natural sonosensitizers for imaging-guided SDT and ferroptosis induction.As an endogenous transporter,hemoglobin(Hb)has dual functions of oxygen and iron supplement.Apparently,Hb can transport iron to the tumor site for Fe-dependent ferroptosis,yet this oxygen carrier is able to enhance the sensitivity of tumor cells to oxygen-driven SDT.We innovatively hybridized Hb,sinoporphyrin sodium(DVDMS),titanium dioxide(TiO_(2))to prepare an integrated nano-oxygen carrier(designated as HDT)for multifarious cancer theranostics,which not only attained satisfactory sonosensitization of DVDMS/TiO_(2)but also achieved oxygen-boosted SDT and potent ferroptosis via Hb.Under ultrasound irradiation,the oxygenation of HDT markedly amplified the generation of reactive oxygen species(ROS)in hypoxic tumors,promoted the valence transition of Hb to accelerate Fenton reaction,led to ferroptosis.This strategy virtually eradicated tumors in situ and exhibited immunoregulatory potential for augmenting anti-tumor effects in vivo and in vitro through ROS formation,O_(2)self-supplement,GSH depletion,lipid peroxidation.Collectively,HDT demonstrated excellent dual-modal imaging performance,providing a valuable platform for photoacoustic/fluorescence-guided SDT and ferroptosis induction in tumor cells.