Introduction Acute angle closure crisis (AACC) is a major ophthalmic emergency. It is a sight-threatening pathology that is very common in women but rarely described in melanodermas. The aim of this work is to investi...Introduction Acute angle closure crisis (AACC) is a major ophthalmic emergency. It is a sight-threatening pathology that is very common in women but rarely described in melanodermas. The aim of this work is to investigate the epidemiological and clinical aspects of acute angle closure crisis. Results We collected 24 patient records, totaling 25 eyes. The average age of our patients was 52.04 years, with a male-to-female ratio of 0.6. A family history of glaucoma occurred in 34% of patients. Patients consulted for a painful red eye associated or not with decreased visual acuity (DVA). The condition was bilateral in one patient. The average visual acuity wax 0.34/10<sup>e</sup>. The cornea was cloudy and the pupil in areflexic mydriasis in all sick eyes. Hypothalamia was present in 72% of eyes and cataracts in 54.16% of cases. The average intraocular press was 44.38 mmHg and the average cup/disc (C/D) was 0.46. Gonioscopy was performed in 7 patients. The fellow eye did not present any abnormalities in 92% of cases. Conclusion The acute angle closure crisis is a rare condition in melanodermas and common in woman. His diagnostic is essentially clinical and completed by gonioscopy which plays a fundamental role. .展开更多
目的探讨巴氯芬联合早期神经肌肉电刺激对脑卒中患者高肌张力的临床疗效。方法选取上海市嘉定区安亭医院2021年1月~2023年1月收治的106例脑卒中后高肌张力患者,随机数表法分为联合组和电刺激组,各53例。电刺激组给予常规治疗并实施早期...目的探讨巴氯芬联合早期神经肌肉电刺激对脑卒中患者高肌张力的临床疗效。方法选取上海市嘉定区安亭医院2021年1月~2023年1月收治的106例脑卒中后高肌张力患者,随机数表法分为联合组和电刺激组,各53例。电刺激组给予常规治疗并实施早期神经肌肉电刺激,联合组加用巴氯芬片,连续治疗4周。评估两组患者治疗前后肢体痉挛状况、肌张力情况、运动功能以及患者日常生活能力;观察两组患者血清炎症指标变化;统计两组患者治疗效果和不良反应。结果联合组患者总有效率为96.23%,高于电刺激组83.02%,差异有统计学意义(χ^(2)=4.970,P<0.05)。治疗后,两组患者临床痉挛指数(CSI)、Ashworth评分明显降低,Fugl-Meyer评分(FMA)、改良Barthel指数(mBI)升高,且联合组治疗后CSI、Ashworth评分低于电刺激组,FMA、mBI则高于电刺激组[(4.65±1.12)分vs.(7.73±1.63)分、(1.38±0.53)分vs.(1.81±0.46)分、(71.47±7.65)分vs.(68.08±6.44)分、(68.92±7.46)分vs.(64.89±7.09)分],差异有统计学意义(t=11.376、2.070、2.634、2.860,P<0.05)。治疗后,两组患者血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、高迁移率族蛋白B1(HMGB1)水平显著降低,且联合组治疗后血清IL-1β、TNF-α、HMGB1水平显著低于电刺激组[(4.63±0.85)pg ml vs.(5.29±0.91)pg ml、(9.58±2.58)pg ml vs.(12.35±3.13)pg ml、(4.51±1.24)μg L vs.(5.68±1.51)μg L],差异有统计学意义(t=3.927、4.921、4.288,P<0.05)。两组患者不良反应发生率相当(16.98%vs.7.55%),差异无统计学意义(χ2=2.192,P>0.05)。结论巴氯芬联合早期神经肌肉电刺激治疗脑卒中患者高肌张力的疗效良好,可有效降低肢体高肌张力状况,提高患肢运动功能,抑制体内炎症反应水平。展开更多
目的观察穴位注射联合新bobath技术治疗卒中后上肢高肌张力的临床疗效。方法选取2019年1月—2021年4月期间铜陵市第二人民医院和铜陵市人民医院收治的84例脑卒中后上肢高肌张力患者,按随机数字表法分为对照组(新bobath技术治疗,42例)和...目的观察穴位注射联合新bobath技术治疗卒中后上肢高肌张力的临床疗效。方法选取2019年1月—2021年4月期间铜陵市第二人民医院和铜陵市人民医院收治的84例脑卒中后上肢高肌张力患者,按随机数字表法分为对照组(新bobath技术治疗,42例)和研究组(穴位注射联合新bobath技术治疗,42例)。治疗1个月后,观察比较两组患者临床疗效,治疗前后改良Ashworth量表(Modified ashworth scales,MAS)分级,Fugl-Meyer运动功能(Fugl-Meyer assessment-upper extremity,FMA)、上肢动作研究量表(Action research arm test,ARAT)以及改良巴氏量表(Modified barthel Index,MBI)评分,中医症状积分(躯体感觉、肢体活动、身体本能)。结果治疗后研究组总有效率97.50%(39/40)明显高于对照组84.21%(32/38),差异有统计学意义(P<0.05)。治疗后两组患者MAS分级均优于治疗前,差异有统计学意义(P<0.05);且研究组效果明显优于对照组,差异有统计学意义(P<0.05)。治疗后两组患者FMA、ARAT、MBI评分均较治疗前升高,差异有统计学意义(P<0.05);且研究组FMA、ARAT、MBI评分均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者躯体感觉、肢体活动、身体本能等中医症状积分均较治疗前降低,差异有统计学意义(P<0.05);且研究组均明显低于对照组,差异有统计学意义(P<0.05)。结论穴位注射联合新bobath技术治疗可更有效的改善脑卒中后上肢高肌张力患者的肌张力状态,提高患侧肢体的运动功能,促进症状缓解,疗效更佳。展开更多
Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson＇s disease, dystonia, and epilepsy. Genetic studies have identified a homozygo...Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson＇s disease, dystonia, and epilepsy. Genetic studies have identified a homozygous truncation mutation in Trakl that causes hypertonia in mice. Moreover, elevated Trakl protein expression is associated with several types of cancers and variants in Trakl are linked to childhood absence epilepsy in humans. Despite the importance of Trakl in health and disease, the mechanisms of Trakl action remain unclear and the pathogenic effects of Trakl mutation are unknown. Here we report that Trakl has a crucial function in regulation of mitochondrial fusion. Depletion of Trakl inhibits mitochondrial fusion, result- ing in mitochondrial fragmentation, whereas overex- pression of Trakl elongates and enlarges mitochondria. Our analyses revealed that Trakl interacts and colocal- izes with mitofusins on the outer mitochondrial mem- brane and functions with mitofusins to promote mitochondrial tethering and fusion. Furthermore, Trakl is required for stress-induced mitochondrial hyperfu- sion and pro-survival response. We found that hyper- tonia-associated mutation impairs Trakl mitochondrial localization and its ability to facilitate mitochondrial tethering and fusion. Our findings uncover a novel function of Trakl as a regulator of mitochondrial fusion and provide evidence linking dysregulated mitochon- drial dynamics to hypertonia pathogenesis.展开更多
文摘Introduction Acute angle closure crisis (AACC) is a major ophthalmic emergency. It is a sight-threatening pathology that is very common in women but rarely described in melanodermas. The aim of this work is to investigate the epidemiological and clinical aspects of acute angle closure crisis. Results We collected 24 patient records, totaling 25 eyes. The average age of our patients was 52.04 years, with a male-to-female ratio of 0.6. A family history of glaucoma occurred in 34% of patients. Patients consulted for a painful red eye associated or not with decreased visual acuity (DVA). The condition was bilateral in one patient. The average visual acuity wax 0.34/10<sup>e</sup>. The cornea was cloudy and the pupil in areflexic mydriasis in all sick eyes. Hypothalamia was present in 72% of eyes and cataracts in 54.16% of cases. The average intraocular press was 44.38 mmHg and the average cup/disc (C/D) was 0.46. Gonioscopy was performed in 7 patients. The fellow eye did not present any abnormalities in 92% of cases. Conclusion The acute angle closure crisis is a rare condition in melanodermas and common in woman. His diagnostic is essentially clinical and completed by gonioscopy which plays a fundamental role. .
文摘目的探讨巴氯芬联合早期神经肌肉电刺激对脑卒中患者高肌张力的临床疗效。方法选取上海市嘉定区安亭医院2021年1月~2023年1月收治的106例脑卒中后高肌张力患者,随机数表法分为联合组和电刺激组,各53例。电刺激组给予常规治疗并实施早期神经肌肉电刺激,联合组加用巴氯芬片,连续治疗4周。评估两组患者治疗前后肢体痉挛状况、肌张力情况、运动功能以及患者日常生活能力;观察两组患者血清炎症指标变化;统计两组患者治疗效果和不良反应。结果联合组患者总有效率为96.23%,高于电刺激组83.02%,差异有统计学意义(χ^(2)=4.970,P<0.05)。治疗后,两组患者临床痉挛指数(CSI)、Ashworth评分明显降低,Fugl-Meyer评分(FMA)、改良Barthel指数(mBI)升高,且联合组治疗后CSI、Ashworth评分低于电刺激组,FMA、mBI则高于电刺激组[(4.65±1.12)分vs.(7.73±1.63)分、(1.38±0.53)分vs.(1.81±0.46)分、(71.47±7.65)分vs.(68.08±6.44)分、(68.92±7.46)分vs.(64.89±7.09)分],差异有统计学意义(t=11.376、2.070、2.634、2.860,P<0.05)。治疗后,两组患者血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、高迁移率族蛋白B1(HMGB1)水平显著降低,且联合组治疗后血清IL-1β、TNF-α、HMGB1水平显著低于电刺激组[(4.63±0.85)pg ml vs.(5.29±0.91)pg ml、(9.58±2.58)pg ml vs.(12.35±3.13)pg ml、(4.51±1.24)μg L vs.(5.68±1.51)μg L],差异有统计学意义(t=3.927、4.921、4.288,P<0.05)。两组患者不良反应发生率相当(16.98%vs.7.55%),差异无统计学意义(χ2=2.192,P>0.05)。结论巴氯芬联合早期神经肌肉电刺激治疗脑卒中患者高肌张力的疗效良好,可有效降低肢体高肌张力状况,提高患肢运动功能,抑制体内炎症反应水平。
文摘目的观察穴位注射联合新bobath技术治疗卒中后上肢高肌张力的临床疗效。方法选取2019年1月—2021年4月期间铜陵市第二人民医院和铜陵市人民医院收治的84例脑卒中后上肢高肌张力患者,按随机数字表法分为对照组(新bobath技术治疗,42例)和研究组(穴位注射联合新bobath技术治疗,42例)。治疗1个月后,观察比较两组患者临床疗效,治疗前后改良Ashworth量表(Modified ashworth scales,MAS)分级,Fugl-Meyer运动功能(Fugl-Meyer assessment-upper extremity,FMA)、上肢动作研究量表(Action research arm test,ARAT)以及改良巴氏量表(Modified barthel Index,MBI)评分,中医症状积分(躯体感觉、肢体活动、身体本能)。结果治疗后研究组总有效率97.50%(39/40)明显高于对照组84.21%(32/38),差异有统计学意义(P<0.05)。治疗后两组患者MAS分级均优于治疗前,差异有统计学意义(P<0.05);且研究组效果明显优于对照组,差异有统计学意义(P<0.05)。治疗后两组患者FMA、ARAT、MBI评分均较治疗前升高,差异有统计学意义(P<0.05);且研究组FMA、ARAT、MBI评分均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者躯体感觉、肢体活动、身体本能等中医症状积分均较治疗前降低,差异有统计学意义(P<0.05);且研究组均明显低于对照组,差异有统计学意义(P<0.05)。结论穴位注射联合新bobath技术治疗可更有效的改善脑卒中后上肢高肌张力患者的肌张力状态,提高患侧肢体的运动功能,促进症状缓解,疗效更佳。
文摘Hypertonia is a neurological dysfunction associated with a number of central nervous system disorders, including cerebral palsy, Parkinson＇s disease, dystonia, and epilepsy. Genetic studies have identified a homozygous truncation mutation in Trakl that causes hypertonia in mice. Moreover, elevated Trakl protein expression is associated with several types of cancers and variants in Trakl are linked to childhood absence epilepsy in humans. Despite the importance of Trakl in health and disease, the mechanisms of Trakl action remain unclear and the pathogenic effects of Trakl mutation are unknown. Here we report that Trakl has a crucial function in regulation of mitochondrial fusion. Depletion of Trakl inhibits mitochondrial fusion, result- ing in mitochondrial fragmentation, whereas overex- pression of Trakl elongates and enlarges mitochondria. Our analyses revealed that Trakl interacts and colocal- izes with mitofusins on the outer mitochondrial mem- brane and functions with mitofusins to promote mitochondrial tethering and fusion. Furthermore, Trakl is required for stress-induced mitochondrial hyperfu- sion and pro-survival response. We found that hyper- tonia-associated mutation impairs Trakl mitochondrial localization and its ability to facilitate mitochondrial tethering and fusion. Our findings uncover a novel function of Trakl as a regulator of mitochondrial fusion and provide evidence linking dysregulated mitochon- drial dynamics to hypertonia pathogenesis.
