[目的]基于数据挖掘探讨中药治疗高血压肾损害的用药规律。[方法]收集中国知网(China National Knowledge Infrastructure,CNKI)建库至2022年3月运用中药治疗高血压肾损害的文献,按照纳入排除标准筛选处方,构建方药数据库,利用数据挖掘...[目的]基于数据挖掘探讨中药治疗高血压肾损害的用药规律。[方法]收集中国知网(China National Knowledge Infrastructure,CNKI)建库至2022年3月运用中药治疗高血压肾损害的文献,按照纳入排除标准筛选处方,构建方药数据库,利用数据挖掘技术对药物频次、类别、性味归经、聚类及关联规则进行分析。[结果]最终纳入文献85篇,方剂90首,中药144味,累及用药频次966次。使用频次前5位的中药依次是牛膝、黄芪、丹参、茯苓、杜仲。累计用药16类,排名前5的类别是补虚药、活血化瘀药、清热药、平肝息风药、利水渗湿药。中药性味及归经分析显示,常用药物以甘、平为主,归经主要为肝经、肾经、脾经。系统聚类可分为6类,涉及六味地黄丸、天麻钩藤饮等。关联规则分析共提取药对关联规则9条,药组关联规则10条,核心配伍的功效为补益肝肾、平肝潜阳。[结论]现代医家认为,高血压肾损害病性为本虚标实,治疗该病当以补虚为核心,随证治以清热利湿、活血化瘀、利水渗湿之法。展开更多
BACKGROUND Hypertension is prevalent in the general population and is regarded as the second leading cause of renal damage and dysfunction,outnumbered only by diabetes.However,the mechanisms remain unclear.AIM To inve...BACKGROUND Hypertension is prevalent in the general population and is regarded as the second leading cause of renal damage and dysfunction,outnumbered only by diabetes.However,the mechanisms remain unclear.AIM To investigate podocyte injury induced by hypertension in the early course without massive proteinuria or renal dysfunction.METHODS The hypertension group comprised 18 patients with hypertension accompanied by microalbuminuria,diagnosed with hypertensive renal injury according to biopsy results.For a comparison of pathological changes in renal tissue,control group 1 comprised 10 healthy volunteers,and control group 2 comprised 16 patients who underwent surgery for renal trauma.RESULTS The hypertension group had significantly higher blood pressure(P=0.000)and microalbuminuria(P=0.000)compared with control group 1.In the hypertension group,urinary podocytes were detected following positive staining of podocytespecific nephrin and/or CD2-associated protein(CD2AP)in urine sediment.Podocyte foot process fusion and a significant decrease in nephrin and/or CD2AP expression in glomeruli were observed in the hypertension group compared with control group 2.This indicated that hypertension caused podocyte injury and detachment from the glomerular basement membrane,which was consistent with urinary detection of podocytes.CONCLUSION Our results suggest that podocyturia appears early in the course of hypertensive renal injury,and may be a sensitive marker for early prediction of hypertensive renal injury.展开更多
文摘[目的]基于数据挖掘探讨中药治疗高血压肾损害的用药规律。[方法]收集中国知网(China National Knowledge Infrastructure,CNKI)建库至2022年3月运用中药治疗高血压肾损害的文献,按照纳入排除标准筛选处方,构建方药数据库,利用数据挖掘技术对药物频次、类别、性味归经、聚类及关联规则进行分析。[结果]最终纳入文献85篇,方剂90首,中药144味,累及用药频次966次。使用频次前5位的中药依次是牛膝、黄芪、丹参、茯苓、杜仲。累计用药16类,排名前5的类别是补虚药、活血化瘀药、清热药、平肝息风药、利水渗湿药。中药性味及归经分析显示,常用药物以甘、平为主,归经主要为肝经、肾经、脾经。系统聚类可分为6类,涉及六味地黄丸、天麻钩藤饮等。关联规则分析共提取药对关联规则9条,药组关联规则10条,核心配伍的功效为补益肝肾、平肝潜阳。[结论]现代医家认为,高血压肾损害病性为本虚标实,治疗该病当以补虚为核心,随证治以清热利湿、活血化瘀、利水渗湿之法。
基金Supported by the Natural Science Foundation of Liaoning Provincial Department of Science and Technology,No.2017225020
文摘BACKGROUND Hypertension is prevalent in the general population and is regarded as the second leading cause of renal damage and dysfunction,outnumbered only by diabetes.However,the mechanisms remain unclear.AIM To investigate podocyte injury induced by hypertension in the early course without massive proteinuria or renal dysfunction.METHODS The hypertension group comprised 18 patients with hypertension accompanied by microalbuminuria,diagnosed with hypertensive renal injury according to biopsy results.For a comparison of pathological changes in renal tissue,control group 1 comprised 10 healthy volunteers,and control group 2 comprised 16 patients who underwent surgery for renal trauma.RESULTS The hypertension group had significantly higher blood pressure(P=0.000)and microalbuminuria(P=0.000)compared with control group 1.In the hypertension group,urinary podocytes were detected following positive staining of podocytespecific nephrin and/or CD2-associated protein(CD2AP)in urine sediment.Podocyte foot process fusion and a significant decrease in nephrin and/or CD2AP expression in glomeruli were observed in the hypertension group compared with control group 2.This indicated that hypertension caused podocyte injury and detachment from the glomerular basement membrane,which was consistent with urinary detection of podocytes.CONCLUSION Our results suggest that podocyturia appears early in the course of hypertensive renal injury,and may be a sensitive marker for early prediction of hypertensive renal injury.
