Gestational hypertension(GH)is a common complication during pregnancy.GH is regarded as a potential public health challenge for pregnant women and infants.Limited evidence has linked ambient air pollution to an increa...Gestational hypertension(GH)is a common complication during pregnancy.GH is regarded as a potential public health challenge for pregnant women and infants.Limited evidence has linked ambient air pollution to an increased GH risk.However,most of the studies were conducted in developed countries,with inconsistent results obtained.The present study was performed to explore whether exposure to particulate matters with an aerodynamic diameter≤2.5(PM2.5)and ozone(O3)was related to elevated odds of GH in a Chinese population.This population-based cohort study involved 38115 pregnant women in Wuhan,China.All information was collected from the Wuhan Maternal and Child Health Management Information System,using standardized quality control.The daily air pollutant data for PM2.5 and O3 were obtained from the 20 monitoring stations of the Wuhan Environmental Monitoring Center during 2014.The nearest monitor approach was applied to individual exposure assessment of PM2.5 and O3 for each participant.After adjusting for major confounders and other air pollutants,a 10μg/m^3 increase in PM25 and O3 concentrations was found to correlate to a 1.14-fold[95%confidence interval(95%CI):1.09,1.20]and a 1.05-fold(95%CI:1.02,1.07)increase in GH risk,respectively.Additionally,stronger relationships between GH risk and PM25 and O3 exposure were observed in women who conceived in winter and summer,respectively.These findings suggest that air pollutants may contribute to the development of GH.展开更多
The growing incidence of obesity and the rising trend of increased age during pregnancy have led to a high number of pregnant women with chronic kidney disease(CKD).Chronic hypertension is commonly associated with CKD...The growing incidence of obesity and the rising trend of increased age during pregnancy have led to a high number of pregnant women with chronic kidney disease(CKD).Chronic hypertension is commonly associated with CKD and is not only the result of renal damage but is also the cause of declining renal function.Pregnancy and its unique physiological adaptations are affected by a decrease in the filtration capacity of the kidneys.Preeclampsia is a disorder of the vascular endothelium and is exacerbated by endothelial dysfunction resulting from CKD.Blood pressure targets must be strictly maintained owing to overlapping disease pathogenesis and to minimize cardiovascular damage.Moreover,preexisting renal dysfunction poses a challenge in identifying superimposed preeclampsia,which alters the management strategies in pregnancy.Fetal outcomes in patients with CKD are considerably affected by the presence of hypertension.This review is expected to aid in developing a focused and individualized treatment plan for hypertension in pregnant women with CKD to improve pregnancy outcomes and preserve postpartum renal function.展开更多
Summary： The prevalence of hypertensive disorders in China was much higher than that in the United States. Considering the large population with wide geographic area of China, we aimed to add more in- formation regar...Summary： The prevalence of hypertensive disorders in China was much higher than that in the United States. Considering the large population with wide geographic area of China, we aimed to add more in- formation regarding the risk factors for hypertensive disorders of pregnancy. A case-control study was performed on 373 hypertensive cases and 507 normotensive controls. Participants were recruited from 2008 to 2014 in Yichang Maternal and Child Health Care Center in Hubei province and Anyang Mater- nal and Child Health Care Hospital in Henan province, China. Socio-demographic factors, fam- ily-related factors, pregnancy-associated factors, factors related to daily life behaviors and psychosocial factors were investigated with respect to hypertensive disorders in pregnancy through well-designed questionnaire. Chi-square test, t-test, univariate logistic regression analysis, and multivariate logistic re- gression analysis were used to find the possible risk factors behind hypertensive disorders in pregnancy. The results showed that family history of cardiovascular diseases （OR=6.18, 95% CI, 2.37 to 16.14）, history of pregnancy-induced hypertension （OR=16.64, 95% CI, 5.74 to 48.22）, low maternal educa- tional level （OR=2.81, 95% CI, 1.30 to 6.04）, and poor relationship with their parents-in-law （OR=3.44, 95% CI, 1.55 to 7.59） had statistically significant associations with hypertensive disorders in pregnancy through multivariate logistic regression analysis. Increased maternal age, increased pre-pregnancy body mass index, living in rural area, low paternal education level, family history of hypertension, passive smoking one year before and/or in pregnancy, and poor sleeping quality were significantly associated with hypertensive disorders in pregnancy from univariate logistic regression analysis while the associa- tions became uncertain when they were entered for multivariate logistic regression analysis. It was con- cluded that family history of cardiovascular diseases, history of pregnancy-induced 展开更多
伴随着对妊娠期高血压疾患(hypertensive disorders of pregnancy)的基础研究和临床研究进展,其诊断标准和分类是随之变迁最为活跃的部分,但在不同学术组织颁布的诊断标准和分类中,仍然有不尽一致之处。值得思考的问题包括:如何看待子...伴随着对妊娠期高血压疾患(hypertensive disorders of pregnancy)的基础研究和临床研究进展,其诊断标准和分类是随之变迁最为活跃的部分,但在不同学术组织颁布的诊断标准和分类中,仍然有不尽一致之处。值得思考的问题包括:如何看待子痫前期的蛋白尿问题,如何看待子痫前期的轻度与重度问题,以及诊断重度子痫前期纳入标准不尽相同等问题。上述问题尤其反映出对子痫前期综合征的多因素和多通路发病的再认识问题。妊娠期高血压疾患的分类和诊断标准的变迁,虽然显示出对疾病认识的不断提升,但是不可忽视的是,患者群体并无实质迁移,重要的是如何将提升的认识,用来指导和提高对这一疾病群体的控制力。展开更多
BACKGROUND Postpartum hypertension poses a considerable health risk.Despite research on gestational hypertension,comprehensive studies focusing on postpartum hypertension in communities are limited.Understanding its p...BACKGROUND Postpartum hypertension poses a considerable health risk.Despite research on gestational hypertension,comprehensive studies focusing on postpartum hypertension in communities are limited.Understanding its prevalence and associated risk factors is crucial for effective prevention and management.AIM To provide insights for postpartum hypertension’s prevention and management.METHODS In total,3297 women who gave birth between June 2021 and December 2022 in Xuhui District,Shanghai were selected.Blood pressure was measured thrice within one month post-delivery during home visits.Eighty-six women with hypertension were followed up for four months to analyze hypertension persistence and its related risk factors.A predictive model for persistent postpartum hypertension was established and verified using the Nomo diagram model.RESULTS Hypertension prevalence 1 month post-delivery was 2.61%(86/3297).Among the 86 pregnant women,32(37.21%)had persistent hypertension at four months post-delivery.Multivariate logistic regression analysis revealed that older age[odds ratio(OR)=1.212;95%confidence interval(CI):1.065–1.380]and higher pre-pregnancy body mass index(BMI)(OR=1.188;95%CI:1.006–1.404)were associated with hypertension(OR=10.781;95%CI:1.006–1.404)during pregnancy.A 95%CI of 1.243–93.480 is a risk factor for persistent postpartum hypertension.The Nomograph model accurately predicted the risk of persistent postpartum hypertension,demonstrating high precision.CONCLUSION In Xuhui,older age,higher pre-pregnancy BMI,and gestational hypertension are risk factors for persistent postpartum hypertension.Our prediction model can identify high-risk individuals,thereby improving patient quality of life.展开更多
目的通过检测妊娠高血压模型大鼠胎盘中可溶性血管内皮生长因子受体-1(s Flt-1)和胎盘生长因子(PLGF)的含量变化,初步探讨黄芪注射液对妊娠高血压大鼠的治疗作用。方法将稳定的妊娠高血压动物模型鼠随机分为5组:分别为模型对照组、黄芪...目的通过检测妊娠高血压模型大鼠胎盘中可溶性血管内皮生长因子受体-1(s Flt-1)和胎盘生长因子(PLGF)的含量变化,初步探讨黄芪注射液对妊娠高血压大鼠的治疗作用。方法将稳定的妊娠高血压动物模型鼠随机分为5组:分别为模型对照组、黄芪注射液低剂量组、黄芪注射液中剂量组、黄芪注射液高剂量组、硫酸镁组,每组6只,同时选取健康的妊娠雌鼠6只作为空白对照组。给予腹腔注射低、中、高剂量黄芪注射液,并以空白组、模型组和硫酸镁组作为对照,观察治疗前后孕鼠血压,尿蛋白水平;于妊娠第21日剖腹取胎盘,提取胎盘组织中核糖核酸(RNA),采用反转录聚合酶链反应(RT-PCR)法分别测定上述2种因子含量的变化。结果黄芪低、中、高组大鼠与模型组大鼠比较,胎盘中s Flt-1 m RNA的表达明显降低,PLGF m RNA的表达明显增高,差异有统计学意义(均P<0.05)。结论黄芪注射液干预妊娠高血压模型鼠后,大鼠胎盘s Flt-1的表达含量降低,PLGF的表达含量升高。展开更多
Objective:To study the correlation between central retinal artery hemodynamic characteristics in patients with hypertensive disorder complicating pregnancy and endothelial injury molecules as well as trophoblast cell ...Objective:To study the correlation between central retinal artery hemodynamic characteristics in patients with hypertensive disorder complicating pregnancy and endothelial injury molecules as well as trophoblast cell apoptosis molecules.Methods: 45 healthy pregnant women, 37 patients with gestational hypertension and 24 patients with preeclampsia who gave birth in Obstetrics Department of our hospital between May 2013 and December 2015 were selected and included in the control group, GH group and PE group respectively. Central retinal artery ultrasonography was done to determine peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistance index (RI), serum was collected to determine interleukin-6 (IL-6), IL-17, IL-24, chemokine ligand 10 (CXCL10) and cartilage glycoprotein 40 (YKL40) content, and placenta tissue was collected to determine Fas, FasL, Bax, Caspase-3, Caspase-9, XIAP, Survivin and Livin expression.Results: Central retinal artery PSV and EDV as well as XIAP, Survivin and Livin expression in placenta of GH group and PE group were significantly lower than those of control group (P<0.05) while central retinal artery RI, serum IL-6, IL-17, IL-24, CXCL10 and YKL40 content as well as Fas, FasL, Bax, Caspase-3 and Caspase-9 expression in placenta were significantly higher than those of control group (P<0.05). Central retinal artery PSV and EDV as well as XIAP, Survivin and Livin expression in placenta of PE group were significantly lower than those of GH group (P<0.05) while central retinal artery RI, serum IL-6, IL-17, IL-24, CXCL10 and YKL40 content as well as Fas, FasL, Bax, Caspase-3 and Caspase-9 expression in placenta were significantly higher than those of GH group (P<0.05). Serum IL-6, IL-17, IL-24, CXCL10 and YKL40 content as well as Fas, FasL, Bax, Caspase-3 and Caspase-9 expression in placenta were negatively correlated with PSV and EDV, and positively correlated with RI;XIAP, Survivin and Livin expression in placenta were positively correlated with PSV and EDV, and negatively correl展开更多
The purpose of this study was to evaluate the prevalence of Hypertensive Disorders in Pregnancy (HDP) and to determine the factors associated with them in the city of Parakou in Benin, a West African country. Method: ...The purpose of this study was to evaluate the prevalence of Hypertensive Disorders in Pregnancy (HDP) and to determine the factors associated with them in the city of Parakou in Benin, a West African country. Method: It has been a descriptive cross-sectional study with a prospective collection of data using a questionnaire in prenatal consultation in the health center of Parakou’s commune for 4 months (May 1 to August 31, 2019). Result: A proportion of 8.2% (55/671) of the pregnancy had </span><span style="font-family:Verdana;">the hypertensive</span><span style="font-family:Verdana;"> disorders of pregnancy. </span><span style="font-family:Verdana;">The Gestational</span><span style="font-family:Verdana;"> HyperTension was the most common type of arterial hypertension (AHT) with a proportion of 49.1%. The factors associated with HDP were the age of 30 to 34 (OR: 11.9;95% CI: 1.54 - 92.29;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0346), the family history of Arterial HyperTension (AHT) (OR: 1.5;95% CI: 1.03 - 4.66;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0481), the BMI > 30 (OR:14.2;95% IC: 7.02 - 28.69;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0235), being married or in a common-law relationship (OR = 2.51;95% CI: 1.30 - 4.86;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0412), the stress (OR: 2.0;95% CI:1.09 - 3.32;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0209), the history of HDP (OR: 9.0;95% CI: 2.53 - 15.23;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> < 0.05). Conclusion: HDP </span><span style="font-family:Verdana;">are</span><span style="font-family:Verdana;"> common in Parakou. Some factors previously described in the literature are associated with them.展开更多
<strong>Introduction:</strong> Hypertension is a major cause of maternal and perinatal morbidity and mortality. This study aims at exploring the outcomes of pregnancy and associated factors in hypertensive...<strong>Introduction:</strong> Hypertension is a major cause of maternal and perinatal morbidity and mortality. This study aims at exploring the outcomes of pregnancy and associated factors in hypertensive pregnant women in Comè district hospital from 2014 to 2016. <strong>Methods:</strong> This is a retrospective, analytical study carried out in June 2016, involving a total of 345 hypertensive patients. Socio-demographic and medical features, including pregnancy and foetal outcomes parameters, were recorded in the case files. Top-down stepwise logistic regression was performed at the 5% threshold. <strong>Results:</strong> The frequency of hypertensive disorders during pregnancy was estimated at 7.32% and unfavourable outcomes at 35.65%. The adverse maternal outcomes recorded were postpartum death and haemorrhage whereas adverse foetal issues were prematurity, low birth weight, low Apgar scores, stillbirth and death. Factors statistically associated with pregnancy outcome were paucigravida (OR = 2.01 ([1.05 - 3.88]), p = 0.035), history of stillbirth (OR = 4.75 ([1.01 - 22.1]), p = 0.048) and anticonvulsant therapy (OR = 0.32 ([0.19 - 0.54]), p < 0.001). <strong>Conclusion:</strong> Adequate monitoring via Antenatal Care (ANC) check-ups, timely recourse to care and an effective communication strategy should reduce hypertensive disorders incidence and adverse outcomes in pregnant women.展开更多
Objective:To investigate effect of iron supplementation on the risk of hypertensive disorders in pregnancy in non-anaemic pregnant women.Methods:A literature search was conducted using three categories of terms with i...Objective:To investigate effect of iron supplementation on the risk of hypertensive disorders in pregnancy in non-anaemic pregnant women.Methods:A literature search was conducted using three categories of terms with its synonyms or related words:"iron","supplement",“hypertensive disorders in pregnancy”through MEDLINE(OVID),CINAHL,PubMed,Cochrane Library,Scopus,Web of Science,ICTRP,and ClinicalTrials.gov,and manual search of references was used in seven potential resources.The inclusion criteria were randomized control trials(RCTs),published in English,full-text available,having healthy pregnant women without anaemia for study participants,and having hypertensive disorders in pregnancy at the end of pregnancy as the outcome.The risk of bias assessment tool was used for quality appraisal.Meta-analysis was conducted by calculating the fixed and random effects of the odds ratio(OR)for iron supplementation among non-anaemic pregnant women compared with the incidence of hypertensive disorders in pregnancy.The range of the study’s estimation accuracy was reflected by a 95%confidence interval(CI).Results:Four RCTs were included in the meta-analysis.The pooled results showed that iron supplementation possibly had no effect on the incidence of hypertensive disorders in pregnancy(OR 0.93,95%CI 0.81-1.07;P=0.30),gestational hypertension(OR 1.37,95%CI 0.69-2.73;P=0.36)as well as on the development of preeclampsia(OR 1.45,95%CI 0.71-2.97;P=0.31).Conclusions:Iron supplementation has no effect on the incidence of hypertension in non-anaemic pregnant women.In general,there is a lack of evidence for the association between iron supplementation and the incidence of hypertensive disorders in pregnancy among non-anaemic pregnant women,and further studies are needed.展开更多
基金the National Key Research&Development Program of China(No.2017YFC0212003)the National Natural Science Foundation of China(No.21577043)the Natural Science Foundation of Hubei Province(No.2010CDB08803).
文摘Gestational hypertension(GH)is a common complication during pregnancy.GH is regarded as a potential public health challenge for pregnant women and infants.Limited evidence has linked ambient air pollution to an increased GH risk.However,most of the studies were conducted in developed countries,with inconsistent results obtained.The present study was performed to explore whether exposure to particulate matters with an aerodynamic diameter≤2.5(PM2.5)and ozone(O3)was related to elevated odds of GH in a Chinese population.This population-based cohort study involved 38115 pregnant women in Wuhan,China.All information was collected from the Wuhan Maternal and Child Health Management Information System,using standardized quality control.The daily air pollutant data for PM2.5 and O3 were obtained from the 20 monitoring stations of the Wuhan Environmental Monitoring Center during 2014.The nearest monitor approach was applied to individual exposure assessment of PM2.5 and O3 for each participant.After adjusting for major confounders and other air pollutants,a 10μg/m^3 increase in PM25 and O3 concentrations was found to correlate to a 1.14-fold[95%confidence interval(95%CI):1.09,1.20]and a 1.05-fold(95%CI:1.02,1.07)increase in GH risk,respectively.Additionally,stronger relationships between GH risk and PM25 and O3 exposure were observed in women who conceived in winter and summer,respectively.These findings suggest that air pollutants may contribute to the development of GH.
文摘The growing incidence of obesity and the rising trend of increased age during pregnancy have led to a high number of pregnant women with chronic kidney disease(CKD).Chronic hypertension is commonly associated with CKD and is not only the result of renal damage but is also the cause of declining renal function.Pregnancy and its unique physiological adaptations are affected by a decrease in the filtration capacity of the kidneys.Preeclampsia is a disorder of the vascular endothelium and is exacerbated by endothelial dysfunction resulting from CKD.Blood pressure targets must be strictly maintained owing to overlapping disease pathogenesis and to minimize cardiovascular damage.Moreover,preexisting renal dysfunction poses a challenge in identifying superimposed preeclampsia,which alters the management strategies in pregnancy.Fetal outcomes in patients with CKD are considerably affected by the presence of hypertension.This review is expected to aid in developing a focused and individualized treatment plan for hypertension in pregnant women with CKD to improve pregnancy outcomes and preserve postpartum renal function.
基金supported by National Natural Science Foundation of China(No.81172679/H2605)
文摘Summary： The prevalence of hypertensive disorders in China was much higher than that in the United States. Considering the large population with wide geographic area of China, we aimed to add more in- formation regarding the risk factors for hypertensive disorders of pregnancy. A case-control study was performed on 373 hypertensive cases and 507 normotensive controls. Participants were recruited from 2008 to 2014 in Yichang Maternal and Child Health Care Center in Hubei province and Anyang Mater- nal and Child Health Care Hospital in Henan province, China. Socio-demographic factors, fam- ily-related factors, pregnancy-associated factors, factors related to daily life behaviors and psychosocial factors were investigated with respect to hypertensive disorders in pregnancy through well-designed questionnaire. Chi-square test, t-test, univariate logistic regression analysis, and multivariate logistic re- gression analysis were used to find the possible risk factors behind hypertensive disorders in pregnancy. The results showed that family history of cardiovascular diseases （OR=6.18, 95% CI, 2.37 to 16.14）, history of pregnancy-induced hypertension （OR=16.64, 95% CI, 5.74 to 48.22）, low maternal educa- tional level （OR=2.81, 95% CI, 1.30 to 6.04）, and poor relationship with their parents-in-law （OR=3.44, 95% CI, 1.55 to 7.59） had statistically significant associations with hypertensive disorders in pregnancy through multivariate logistic regression analysis. Increased maternal age, increased pre-pregnancy body mass index, living in rural area, low paternal education level, family history of hypertension, passive smoking one year before and/or in pregnancy, and poor sleeping quality were significantly associated with hypertensive disorders in pregnancy from univariate logistic regression analysis while the associa- tions became uncertain when they were entered for multivariate logistic regression analysis. It was con- cluded that family history of cardiovascular diseases, history of pregnancy-induced
文摘伴随着对妊娠期高血压疾患(hypertensive disorders of pregnancy)的基础研究和临床研究进展,其诊断标准和分类是随之变迁最为活跃的部分,但在不同学术组织颁布的诊断标准和分类中,仍然有不尽一致之处。值得思考的问题包括:如何看待子痫前期的蛋白尿问题,如何看待子痫前期的轻度与重度问题,以及诊断重度子痫前期纳入标准不尽相同等问题。上述问题尤其反映出对子痫前期综合征的多因素和多通路发病的再认识问题。妊娠期高血压疾患的分类和诊断标准的变迁,虽然显示出对疾病认识的不断提升,但是不可忽视的是,患者群体并无实质迁移,重要的是如何将提升的认识,用来指导和提高对这一疾病群体的控制力。
文摘BACKGROUND Postpartum hypertension poses a considerable health risk.Despite research on gestational hypertension,comprehensive studies focusing on postpartum hypertension in communities are limited.Understanding its prevalence and associated risk factors is crucial for effective prevention and management.AIM To provide insights for postpartum hypertension’s prevention and management.METHODS In total,3297 women who gave birth between June 2021 and December 2022 in Xuhui District,Shanghai were selected.Blood pressure was measured thrice within one month post-delivery during home visits.Eighty-six women with hypertension were followed up for four months to analyze hypertension persistence and its related risk factors.A predictive model for persistent postpartum hypertension was established and verified using the Nomo diagram model.RESULTS Hypertension prevalence 1 month post-delivery was 2.61%(86/3297).Among the 86 pregnant women,32(37.21%)had persistent hypertension at four months post-delivery.Multivariate logistic regression analysis revealed that older age[odds ratio(OR)=1.212;95%confidence interval(CI):1.065–1.380]and higher pre-pregnancy body mass index(BMI)(OR=1.188;95%CI:1.006–1.404)were associated with hypertension(OR=10.781;95%CI:1.006–1.404)during pregnancy.A 95%CI of 1.243–93.480 is a risk factor for persistent postpartum hypertension.The Nomograph model accurately predicted the risk of persistent postpartum hypertension,demonstrating high precision.CONCLUSION In Xuhui,older age,higher pre-pregnancy BMI,and gestational hypertension are risk factors for persistent postpartum hypertension.Our prediction model can identify high-risk individuals,thereby improving patient quality of life.
文摘目的通过检测妊娠高血压模型大鼠胎盘中可溶性血管内皮生长因子受体-1(s Flt-1)和胎盘生长因子(PLGF)的含量变化,初步探讨黄芪注射液对妊娠高血压大鼠的治疗作用。方法将稳定的妊娠高血压动物模型鼠随机分为5组:分别为模型对照组、黄芪注射液低剂量组、黄芪注射液中剂量组、黄芪注射液高剂量组、硫酸镁组,每组6只,同时选取健康的妊娠雌鼠6只作为空白对照组。给予腹腔注射低、中、高剂量黄芪注射液,并以空白组、模型组和硫酸镁组作为对照,观察治疗前后孕鼠血压,尿蛋白水平;于妊娠第21日剖腹取胎盘,提取胎盘组织中核糖核酸(RNA),采用反转录聚合酶链反应(RT-PCR)法分别测定上述2种因子含量的变化。结果黄芪低、中、高组大鼠与模型组大鼠比较,胎盘中s Flt-1 m RNA的表达明显降低,PLGF m RNA的表达明显增高,差异有统计学意义(均P<0.05)。结论黄芪注射液干预妊娠高血压模型鼠后,大鼠胎盘s Flt-1的表达含量降低,PLGF的表达含量升高。
文摘目的 观察硝酸甘油与硫酸镁治疗妊娠高血压危象的降压疗效.方法 妊娠高血压危象40例,在血压、心电监护下,用硝酸甘油10mg＋5%葡萄糖250mL,静脉滴注,25～100 μg/min,同时联用硫酸镁.结果 用药1h后,显效30例,有效10例,未见无效病例,显效率75%,总有效率100%,血压全部降至预期值,用药1h后,收缩压[SBP：（23.5±1.6 vs 19.9±1.2）kPa,P＜0.05]和舒张压[DBP：（15.6±0.8 vs 12.0±0.7）kPa,P＜0.05]均明显下降,治疗前、后心率（含胎儿心率）无明显变化（P＞0.05）.结论 硝酸甘油起效快,降压平稳,无不良反应,对母婴安全,值得妊娠高血压危象患者应用.
文摘Objective:To study the correlation between central retinal artery hemodynamic characteristics in patients with hypertensive disorder complicating pregnancy and endothelial injury molecules as well as trophoblast cell apoptosis molecules.Methods: 45 healthy pregnant women, 37 patients with gestational hypertension and 24 patients with preeclampsia who gave birth in Obstetrics Department of our hospital between May 2013 and December 2015 were selected and included in the control group, GH group and PE group respectively. Central retinal artery ultrasonography was done to determine peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistance index (RI), serum was collected to determine interleukin-6 (IL-6), IL-17, IL-24, chemokine ligand 10 (CXCL10) and cartilage glycoprotein 40 (YKL40) content, and placenta tissue was collected to determine Fas, FasL, Bax, Caspase-3, Caspase-9, XIAP, Survivin and Livin expression.Results: Central retinal artery PSV and EDV as well as XIAP, Survivin and Livin expression in placenta of GH group and PE group were significantly lower than those of control group (P<0.05) while central retinal artery RI, serum IL-6, IL-17, IL-24, CXCL10 and YKL40 content as well as Fas, FasL, Bax, Caspase-3 and Caspase-9 expression in placenta were significantly higher than those of control group (P<0.05). Central retinal artery PSV and EDV as well as XIAP, Survivin and Livin expression in placenta of PE group were significantly lower than those of GH group (P<0.05) while central retinal artery RI, serum IL-6, IL-17, IL-24, CXCL10 and YKL40 content as well as Fas, FasL, Bax, Caspase-3 and Caspase-9 expression in placenta were significantly higher than those of GH group (P<0.05). Serum IL-6, IL-17, IL-24, CXCL10 and YKL40 content as well as Fas, FasL, Bax, Caspase-3 and Caspase-9 expression in placenta were negatively correlated with PSV and EDV, and positively correlated with RI;XIAP, Survivin and Livin expression in placenta were positively correlated with PSV and EDV, and negatively correl
文摘The purpose of this study was to evaluate the prevalence of Hypertensive Disorders in Pregnancy (HDP) and to determine the factors associated with them in the city of Parakou in Benin, a West African country. Method: It has been a descriptive cross-sectional study with a prospective collection of data using a questionnaire in prenatal consultation in the health center of Parakou’s commune for 4 months (May 1 to August 31, 2019). Result: A proportion of 8.2% (55/671) of the pregnancy had </span><span style="font-family:Verdana;">the hypertensive</span><span style="font-family:Verdana;"> disorders of pregnancy. </span><span style="font-family:Verdana;">The Gestational</span><span style="font-family:Verdana;"> HyperTension was the most common type of arterial hypertension (AHT) with a proportion of 49.1%. The factors associated with HDP were the age of 30 to 34 (OR: 11.9;95% CI: 1.54 - 92.29;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0346), the family history of Arterial HyperTension (AHT) (OR: 1.5;95% CI: 1.03 - 4.66;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0481), the BMI > 30 (OR:14.2;95% IC: 7.02 - 28.69;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0235), being married or in a common-law relationship (OR = 2.51;95% CI: 1.30 - 4.86;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0412), the stress (OR: 2.0;95% CI:1.09 - 3.32;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.0209), the history of HDP (OR: 9.0;95% CI: 2.53 - 15.23;</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> < 0.05). Conclusion: HDP </span><span style="font-family:Verdana;">are</span><span style="font-family:Verdana;"> common in Parakou. Some factors previously described in the literature are associated with them.
文摘<strong>Introduction:</strong> Hypertension is a major cause of maternal and perinatal morbidity and mortality. This study aims at exploring the outcomes of pregnancy and associated factors in hypertensive pregnant women in Comè district hospital from 2014 to 2016. <strong>Methods:</strong> This is a retrospective, analytical study carried out in June 2016, involving a total of 345 hypertensive patients. Socio-demographic and medical features, including pregnancy and foetal outcomes parameters, were recorded in the case files. Top-down stepwise logistic regression was performed at the 5% threshold. <strong>Results:</strong> The frequency of hypertensive disorders during pregnancy was estimated at 7.32% and unfavourable outcomes at 35.65%. The adverse maternal outcomes recorded were postpartum death and haemorrhage whereas adverse foetal issues were prematurity, low birth weight, low Apgar scores, stillbirth and death. Factors statistically associated with pregnancy outcome were paucigravida (OR = 2.01 ([1.05 - 3.88]), p = 0.035), history of stillbirth (OR = 4.75 ([1.01 - 22.1]), p = 0.048) and anticonvulsant therapy (OR = 0.32 ([0.19 - 0.54]), p < 0.001). <strong>Conclusion:</strong> Adequate monitoring via Antenatal Care (ANC) check-ups, timely recourse to care and an effective communication strategy should reduce hypertensive disorders incidence and adverse outcomes in pregnant women.
基金This study was funded by the Indonesia Endowment Fund for Education(LPDP)with Reference number S-422/LPDP.3/2018.
文摘Objective:To investigate effect of iron supplementation on the risk of hypertensive disorders in pregnancy in non-anaemic pregnant women.Methods:A literature search was conducted using three categories of terms with its synonyms or related words:"iron","supplement",“hypertensive disorders in pregnancy”through MEDLINE(OVID),CINAHL,PubMed,Cochrane Library,Scopus,Web of Science,ICTRP,and ClinicalTrials.gov,and manual search of references was used in seven potential resources.The inclusion criteria were randomized control trials(RCTs),published in English,full-text available,having healthy pregnant women without anaemia for study participants,and having hypertensive disorders in pregnancy at the end of pregnancy as the outcome.The risk of bias assessment tool was used for quality appraisal.Meta-analysis was conducted by calculating the fixed and random effects of the odds ratio(OR)for iron supplementation among non-anaemic pregnant women compared with the incidence of hypertensive disorders in pregnancy.The range of the study’s estimation accuracy was reflected by a 95%confidence interval(CI).Results:Four RCTs were included in the meta-analysis.The pooled results showed that iron supplementation possibly had no effect on the incidence of hypertensive disorders in pregnancy(OR 0.93,95%CI 0.81-1.07;P=0.30),gestational hypertension(OR 1.37,95%CI 0.69-2.73;P=0.36)as well as on the development of preeclampsia(OR 1.45,95%CI 0.71-2.97;P=0.31).Conclusions:Iron supplementation has no effect on the incidence of hypertension in non-anaemic pregnant women.In general,there is a lack of evidence for the association between iron supplementation and the incidence of hypertensive disorders in pregnancy among non-anaemic pregnant women,and further studies are needed.
