Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation,repair and regeneration.Through cell fusion somatic cells undergo rapid nuclear reprogramming and e...Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation,repair and regeneration.Through cell fusion somatic cells undergo rapid nuclear reprogramming and epigenetic modifications to form hybrid cells with new genetic and phenotypic properties at a rate exceeding that achievable by random mutations.Factors that stimulate cell fusion are inflammation and hypoxia.Fusion of cancer cells with non-neoplastic cells facilitates several malignancy-related cell phenotypes,e.g.,reprogramming of somatic cell into induced pluripotent stem cells and epithelial to mesenchymal transition.There is now considerable in vitro,in vivo and clinical evidence that fusion of cancer cells with motile leucocytes such as macrophages plays a major role in cancer metastasis.Of the many changes in cancer cells after hybridizing with leucocytes,it is notable that hybrids acquire resistance to chemo-and radiation therapy.One phenomenon that has been largely overlooked yet plays a role in these processes is polyploidization.Regardless of the mechanism of polyploid cell formation,it happens in response to genotoxic stresses and enhances a cancer cell’s ability to survive.Here we summarize the recent progress in research of cell fusion and with a focus on an important role for polyploid cells in cancer metastasis.In addition,we discuss the clinical evidence and the importance of cell fusion and polyploidization in solid tumors.展开更多
This paper examines the optimal forecast-sharing strategy in a hybrid-format online platform supply chain where a supplier sells a product through agency format and reselling format provided by a platform retailer who...This paper examines the optimal forecast-sharing strategy in a hybrid-format online platform supply chain where a supplier sells a product through agency format and reselling format provided by a platform retailer who possesses demand forecasts from two channels.Forecast asymmetry and co-opetitive relationship arise between the platform retailer and the supplier,which affect their operational decisions and the supply chain’s performance.To improve supply chain efficiency,we compare different forecast-sharing strategies(i.e.,no forecast sharing,sharing a single forecast,and sharing two forecasts),and analyze the effects of co-opetitive parameters on the optimal forecast-sharing strategy.Our analysis shows that forecast sharing is always beneficial to the supplier,and sharing two forecasts is more beneficial than sharing a single forecast.Whereas for the platform retailer and the whole supply chain,forecast sharing is beneficial only under certain conditions,depending on the co-opetitive parameters.The optimal forecast-sharing strategy is the result of a combination of the negative effect of double marginalization in reselling channel and the positive effect of responding pricing to demand uncertainty in agency channel.We illustrate the parameter regions of the platform retailer’s voluntary sharing,contract sharing,and no sharing,and also find that higher channel competition intensity,higher market share of agency channel,and higher commission rate can promote the platform retailer’s voluntary sharing.Our study extends the research scope of demand forecast-sharing and sheds light on the decision-making processes for managing a hybrid-format online platform supply chain.展开更多
文摘Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation,repair and regeneration.Through cell fusion somatic cells undergo rapid nuclear reprogramming and epigenetic modifications to form hybrid cells with new genetic and phenotypic properties at a rate exceeding that achievable by random mutations.Factors that stimulate cell fusion are inflammation and hypoxia.Fusion of cancer cells with non-neoplastic cells facilitates several malignancy-related cell phenotypes,e.g.,reprogramming of somatic cell into induced pluripotent stem cells and epithelial to mesenchymal transition.There is now considerable in vitro,in vivo and clinical evidence that fusion of cancer cells with motile leucocytes such as macrophages plays a major role in cancer metastasis.Of the many changes in cancer cells after hybridizing with leucocytes,it is notable that hybrids acquire resistance to chemo-and radiation therapy.One phenomenon that has been largely overlooked yet plays a role in these processes is polyploidization.Regardless of the mechanism of polyploid cell formation,it happens in response to genotoxic stresses and enhances a cancer cell’s ability to survive.Here we summarize the recent progress in research of cell fusion and with a focus on an important role for polyploid cells in cancer metastasis.In addition,we discuss the clinical evidence and the importance of cell fusion and polyploidization in solid tumors.
基金supported in part by National Natural Science Foundation of China under Grant Nos.72171169 and 71971076.
文摘This paper examines the optimal forecast-sharing strategy in a hybrid-format online platform supply chain where a supplier sells a product through agency format and reselling format provided by a platform retailer who possesses demand forecasts from two channels.Forecast asymmetry and co-opetitive relationship arise between the platform retailer and the supplier,which affect their operational decisions and the supply chain’s performance.To improve supply chain efficiency,we compare different forecast-sharing strategies(i.e.,no forecast sharing,sharing a single forecast,and sharing two forecasts),and analyze the effects of co-opetitive parameters on the optimal forecast-sharing strategy.Our analysis shows that forecast sharing is always beneficial to the supplier,and sharing two forecasts is more beneficial than sharing a single forecast.Whereas for the platform retailer and the whole supply chain,forecast sharing is beneficial only under certain conditions,depending on the co-opetitive parameters.The optimal forecast-sharing strategy is the result of a combination of the negative effect of double marginalization in reselling channel and the positive effect of responding pricing to demand uncertainty in agency channel.We illustrate the parameter regions of the platform retailer’s voluntary sharing,contract sharing,and no sharing,and also find that higher channel competition intensity,higher market share of agency channel,and higher commission rate can promote the platform retailer’s voluntary sharing.Our study extends the research scope of demand forecast-sharing and sheds light on the decision-making processes for managing a hybrid-format online platform supply chain.
