Microstructural evolution and mechanical properties of in situ TiB2/A1 composites fabricated with exothermic reaction process under high-intensity ultra- sound produced by the magnetostrictive transducer were investig...Microstructural evolution and mechanical properties of in situ TiB2/A1 composites fabricated with exothermic reaction process under high-intensity ultra- sound produced by the magnetostrictive transducer were investigated. In this method, the microstructure and grain refining performance of the TiB2/A1 composites were characterized by optical morphology （OM）, scanning electron microscopy （SEM）, energy-dispersive spec- trometer （EDS）, and X-ray diffraction （XRD） analysis. Microstructural observations show a decreasing trend in the grain size of the composites due to the ultrasound and the content of TiB2 particles in the composites. Compared with the process without ultrasound, the morphology and ag- glomeration of TiB2 particles are improved by high-in- tensity ultrasound. Meanwhile, it is proposed that the formation of TiBz particles occurs via the transformation from TiA13, and at the optimal amount of the reactants, the conversion efficiency of TiA13 into TiB2 almost reaches up to 100 %. Finally, the effects of high-intensity ultrasound and TiB2 particles on the mechanical properties of the TiB2/A1 composites were also discussed.展开更多
目的探究高强度超声波联合加巴喷丁对神经病理性疼痛患者微小RNA-19a(microrna-19a,miR-19a)、微小RNA-30b(microrna-30b,miR-30b)、微小RNA-29c(microrna-29c,miR-29c)的影响。方法选取神经病理性疼痛患者72例,按照随机法将其分为对照...目的探究高强度超声波联合加巴喷丁对神经病理性疼痛患者微小RNA-19a(microrna-19a,miR-19a)、微小RNA-30b(microrna-30b,miR-30b)、微小RNA-29c(microrna-29c,miR-29c)的影响。方法选取神经病理性疼痛患者72例,按照随机法将其分为对照组35例和联合组37例。对照组使用加巴喷丁治疗,联合组在对照组基础上联合高强度超声波治疗。比较2组美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、改良Barthel指数、白细胞介素6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、视觉模拟评分法(visual analogue scale,VAS)评分、神经病理性疼痛量表(neuropathic pain scale,NPS)评分、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、miR-19a、miR-30b、miR-29c水平、治疗效果和不良反应发生情况。结果治疗后,2组NIHSS评分、IL-6、CRP、VAS评分、NPS评分、miR-19a、miR-30b、miR-29c表达水平低于治疗前,改良Barthel指数、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平高于治疗前,联合组NIHSS评分、IL-6、CRP、VAS评分、NPS评分、miR-19a、miR-30b、miR-29c表达水平低于对照组,改良Barthel指数、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平高于对照组(P<0.05)。联合组临床治疗总有效率高于对照组(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论高强度超声波联合加巴喷丁治疗神经病理性疼痛患者,能明显改善神经功能和免疫功能,减轻疼痛感和炎症反应,调控miR-19a、miR-30b、miR-29c表达,治疗效果明显。展开更多
基金financially supported by the National High Technology Research and Development Program of China(No.2013AA031104)
文摘Microstructural evolution and mechanical properties of in situ TiB2/A1 composites fabricated with exothermic reaction process under high-intensity ultra- sound produced by the magnetostrictive transducer were investigated. In this method, the microstructure and grain refining performance of the TiB2/A1 composites were characterized by optical morphology （OM）, scanning electron microscopy （SEM）, energy-dispersive spec- trometer （EDS）, and X-ray diffraction （XRD） analysis. Microstructural observations show a decreasing trend in the grain size of the composites due to the ultrasound and the content of TiB2 particles in the composites. Compared with the process without ultrasound, the morphology and ag- glomeration of TiB2 particles are improved by high-in- tensity ultrasound. Meanwhile, it is proposed that the formation of TiBz particles occurs via the transformation from TiA13, and at the optimal amount of the reactants, the conversion efficiency of TiA13 into TiB2 almost reaches up to 100 %. Finally, the effects of high-intensity ultrasound and TiB2 particles on the mechanical properties of the TiB2/A1 composites were also discussed.
文摘目的探究高强度超声波联合加巴喷丁对神经病理性疼痛患者微小RNA-19a(microrna-19a,miR-19a)、微小RNA-30b(microrna-30b,miR-30b)、微小RNA-29c(microrna-29c,miR-29c)的影响。方法选取神经病理性疼痛患者72例,按照随机法将其分为对照组35例和联合组37例。对照组使用加巴喷丁治疗,联合组在对照组基础上联合高强度超声波治疗。比较2组美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、改良Barthel指数、白细胞介素6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、视觉模拟评分法(visual analogue scale,VAS)评分、神经病理性疼痛量表(neuropathic pain scale,NPS)评分、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、miR-19a、miR-30b、miR-29c水平、治疗效果和不良反应发生情况。结果治疗后,2组NIHSS评分、IL-6、CRP、VAS评分、NPS评分、miR-19a、miR-30b、miR-29c表达水平低于治疗前,改良Barthel指数、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平高于治疗前,联合组NIHSS评分、IL-6、CRP、VAS评分、NPS评分、miR-19a、miR-30b、miR-29c表达水平低于对照组,改良Barthel指数、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平高于对照组(P<0.05)。联合组临床治疗总有效率高于对照组(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论高强度超声波联合加巴喷丁治疗神经病理性疼痛患者,能明显改善神经功能和免疫功能,减轻疼痛感和炎症反应,调控miR-19a、miR-30b、miR-29c表达,治疗效果明显。
