Climate change is one of the biggest health threats of the 21st century.Although China is the biggest developing country,with a large population and different climate types,its projections of large-scale heat-related ...Climate change is one of the biggest health threats of the 21st century.Although China is the biggest developing country,with a large population and different climate types,its projections of large-scale heat-related excess mortality remain understudied.In particular,the effects of climate change on aging populations have not been well studied,and may result in significantly underestimation of heat effects.In this study,we took four climate change scenarios of Tier-1 in CMIP6,which were combinations of Shared Socioeconomic Pathways(SSPs)and Representative Concentration Pathways(RCPs).We used the exposure-response functions derived from previous studies combined with baseline age-specific non-accidental mortality rates to project heat-related excess mortality.Then,we employed the Logarithmic Mean Divisia Index(LMDI)method to decompose the impacts of climate change,population growth,and aging on heat-related excess mortality.Finally,we multiplied the heat-related Years of Life Lost(YLL)with the Value of a Statistical Life Year(VSLY)to quantify the economic burden of premature mortality.We found that the heat-related excess mortality would be concentrated in central China and in the densely populated south-eastern coastal regions.When aging is considered,heat-related excess mortality will become 2.8–6.7 times than that without considering aging in 2081–2100 under different scenarios.The contribution analysis showed that the effect of aging on heat-related deaths would be much higher than that of climate change.Our findings highlighted that aging would lead to a severe increase of heat-related deaths and suggesting that regional-specific policies should be formulated in response to heat-related risks.展开更多
BACKGROUND: This study aimed to investigate the epidemiological and clinical characteristics of patients with heat-related illness, and guide the prevention, diagnosis and treatment of heat-related illness.METHODS: Fr...BACKGROUND: This study aimed to investigate the epidemiological and clinical characteristics of patients with heat-related illness, and guide the prevention, diagnosis and treatment of heat-related illness.METHODS: From June 2013 to August 2013, seventy patients with heat-related illness were treated at Jinshan Hospital of Fudan University, and their epidemiological characteristics, laboratory results, treatment and prognosis were retrospectively analyzed.RESULTS: In the 70 patients, 18 patients suffered from heat stroke and 52 patients from nonheat stroke. When the environmnent temperature was above 35 °C, the body temperature of the patients began to increase markedly. The patients with heat stroke were significantly older than those with non-heat stroke(P<0.05). The body temperature, heart rate, blood glucose, blood lactate dehydrogenase and blood creatine kinase in the patients with heat stroke were higher than those in the patients with non-heat stroke(P<0.05). Blood lactate dehydrogenase and blood creatine kinase were positively correlated with body temperature(r=0.801).CONCLUSION: When the environmental temperature goes above 35 °C, heat-related illness should be prevented, especially in the elderly. The body temperature, heart rate, blood glucose, blood lactate dehydrogenase and blood creatine kinase in patients with heat stroke are higher than those in patients with non-heat stroke. Blood lactate dehydrogenase and blood creatine kinase are positively correlated with body temperature, but their relationship with heat-related illness awaits further study.展开更多
Background： In Japan, the demand for emergency transportation for people with heat-related illness has recently increased. The purpose of this study was to investigate the relationship between incidents of heat-relat...Background： In Japan, the demand for emergency transportation for people with heat-related illness has recently increased. The purpose of this study was to investigate the relationship between incidents of heat-related illness and the daily maximum temperature. Methods： The daily maximum temperatures in Japan＇s 11 districts over the past 10 years were classified into four categories, with cutoff points at the 50th, 75th, 95th, and higher than 95th percentiles. We then conducted a logistic regression analysis of einergency transportation demand in each temperature category by age group, using the 50th percentile as tile reference category for each area. Results： There were 42,931 cases of emelgency transportation due to heat-related diseases during the study period. Classified by age. 12.5%, 43.4%, and 44.1% of cases involved children, adults, and elderly people, respectively. The analysis showed that the number of cases of emergency transportation for people with heat-related diseases （per 100,000 people; corresponding to a 1.0~C increase in the daily maximum temperature） was 0.016-0.106 among children （24.9-169.9 children required emergency transportation for heat-related diseases）, from 0.013 to 0.059 among adults （19.8 98.2 adults required emergency transportation）, and from 0.045 to 0.159 among elderly persons （30.0 145.4 elderly people required emergency transportation）. The risk was highest for elderly persons, followed by children and finally adults. Cases of emergency transportation due to heat-related illness increased by 2.4-8.9 times when the daily maximum temperature was approximately 1.5℃ above the mean daily maximum temperature. In fact, the daily maximum temperature had a larger effect than the daily relative humidity level oil emergency transportation for people with heat-related diseases. Conclusion： Public health organizations and health-care services should support elderly people and children, two high-risk groups for heat-related diseases.展开更多
In this article we propose a novel hurdle negative binomial (HNB) regression combined with a distributed lag nonlinear model (DLNM) to model weather factors’ impact on heat related illness (HRI) in Singapore. AIC cri...In this article we propose a novel hurdle negative binomial (HNB) regression combined with a distributed lag nonlinear model (DLNM) to model weather factors’ impact on heat related illness (HRI) in Singapore. AIC criterion is adopted to help select proper combination of weather variables and check their lagged effect as well as nonlinear effect. The process of model selection and validation is demonstrated. It is observed that the predicted occurrence rate is close to the observed one. The proposed combined model can be used to predict HRI cases for mitigating HRI occurrences and provide inputs for related public health policy considering climate change impact.展开更多
Vascular endothelium plays an important role in regulating vascular homeostasis. Over the past years, it has become clear that endothelial dysfunction is a key event of pathophysiological changes in the initiation and...Vascular endothelium plays an important role in regulating vascular homeostasis. Over the past years, it has become clear that endothelial dysfunction is a key event of pathophysiological changes in the initiation and progression of injuries induced by extreme environmental factors. The present review summarizes current understanding of vascular endothelial dysfunction induced by hypoxia, cold and heat, and provides the information for prevention and treatment of environmental exposure injuries.展开更多
基金supported by the National Natural Science Foundation of China(No.72091514)the Energy Foundation(No.G-2206-33982)+1 种基金the Tsinghua-Toyota Joint Research Fund,Wellcome Trust(No.209734/Z/17/Z)the GEIGC Science and Technology Project in the framework of the“Research on Comprehensive Path Evaluation Methods and Practical Models for the Synergetic Development of Global Energy,Atmospheric Environment and Human Health”(No.SGGEIG00JYJS2100056).
文摘Climate change is one of the biggest health threats of the 21st century.Although China is the biggest developing country,with a large population and different climate types,its projections of large-scale heat-related excess mortality remain understudied.In particular,the effects of climate change on aging populations have not been well studied,and may result in significantly underestimation of heat effects.In this study,we took four climate change scenarios of Tier-1 in CMIP6,which were combinations of Shared Socioeconomic Pathways(SSPs)and Representative Concentration Pathways(RCPs).We used the exposure-response functions derived from previous studies combined with baseline age-specific non-accidental mortality rates to project heat-related excess mortality.Then,we employed the Logarithmic Mean Divisia Index(LMDI)method to decompose the impacts of climate change,population growth,and aging on heat-related excess mortality.Finally,we multiplied the heat-related Years of Life Lost(YLL)with the Value of a Statistical Life Year(VSLY)to quantify the economic burden of premature mortality.We found that the heat-related excess mortality would be concentrated in central China and in the densely populated south-eastern coastal regions.When aging is considered,heat-related excess mortality will become 2.8–6.7 times than that without considering aging in 2081–2100 under different scenarios.The contribution analysis showed that the effect of aging on heat-related deaths would be much higher than that of climate change.Our findings highlighted that aging would lead to a severe increase of heat-related deaths and suggesting that regional-specific policies should be formulated in response to heat-related risks.
文摘BACKGROUND: This study aimed to investigate the epidemiological and clinical characteristics of patients with heat-related illness, and guide the prevention, diagnosis and treatment of heat-related illness.METHODS: From June 2013 to August 2013, seventy patients with heat-related illness were treated at Jinshan Hospital of Fudan University, and their epidemiological characteristics, laboratory results, treatment and prognosis were retrospectively analyzed.RESULTS: In the 70 patients, 18 patients suffered from heat stroke and 52 patients from nonheat stroke. When the environmnent temperature was above 35 °C, the body temperature of the patients began to increase markedly. The patients with heat stroke were significantly older than those with non-heat stroke(P<0.05). The body temperature, heart rate, blood glucose, blood lactate dehydrogenase and blood creatine kinase in the patients with heat stroke were higher than those in the patients with non-heat stroke(P<0.05). Blood lactate dehydrogenase and blood creatine kinase were positively correlated with body temperature(r=0.801).CONCLUSION: When the environmental temperature goes above 35 °C, heat-related illness should be prevented, especially in the elderly. The body temperature, heart rate, blood glucose, blood lactate dehydrogenase and blood creatine kinase in patients with heat stroke are higher than those in patients with non-heat stroke. Blood lactate dehydrogenase and blood creatine kinase are positively correlated with body temperature, but their relationship with heat-related illness awaits further study.
文摘Background： In Japan, the demand for emergency transportation for people with heat-related illness has recently increased. The purpose of this study was to investigate the relationship between incidents of heat-related illness and the daily maximum temperature. Methods： The daily maximum temperatures in Japan＇s 11 districts over the past 10 years were classified into four categories, with cutoff points at the 50th, 75th, 95th, and higher than 95th percentiles. We then conducted a logistic regression analysis of einergency transportation demand in each temperature category by age group, using the 50th percentile as tile reference category for each area. Results： There were 42,931 cases of emelgency transportation due to heat-related diseases during the study period. Classified by age. 12.5%, 43.4%, and 44.1% of cases involved children, adults, and elderly people, respectively. The analysis showed that the number of cases of emergency transportation for people with heat-related diseases （per 100,000 people; corresponding to a 1.0~C increase in the daily maximum temperature） was 0.016-0.106 among children （24.9-169.9 children required emergency transportation for heat-related diseases）, from 0.013 to 0.059 among adults （19.8 98.2 adults required emergency transportation）, and from 0.045 to 0.159 among elderly persons （30.0 145.4 elderly people required emergency transportation）. The risk was highest for elderly persons, followed by children and finally adults. Cases of emergency transportation due to heat-related illness increased by 2.4-8.9 times when the daily maximum temperature was approximately 1.5℃ above the mean daily maximum temperature. In fact, the daily maximum temperature had a larger effect than the daily relative humidity level oil emergency transportation for people with heat-related diseases. Conclusion： Public health organizations and health-care services should support elderly people and children, two high-risk groups for heat-related diseases.
文摘In this article we propose a novel hurdle negative binomial (HNB) regression combined with a distributed lag nonlinear model (DLNM) to model weather factors’ impact on heat related illness (HRI) in Singapore. AIC criterion is adopted to help select proper combination of weather variables and check their lagged effect as well as nonlinear effect. The process of model selection and validation is demonstrated. It is observed that the predicted occurrence rate is close to the observed one. The proposed combined model can be used to predict HRI cases for mitigating HRI occurrences and provide inputs for related public health policy considering climate change impact.
基金was supported by grants from the State 973 Research Project(2012CB518206)the National Natural Science Foundation of China(81171870)the State Key Research Project of China(AWS11J003)
文摘Vascular endothelium plays an important role in regulating vascular homeostasis. Over the past years, it has become clear that endothelial dysfunction is a key event of pathophysiological changes in the initiation and progression of injuries induced by extreme environmental factors. The present review summarizes current understanding of vascular endothelial dysfunction induced by hypoxia, cold and heat, and provides the information for prevention and treatment of environmental exposure injuries.
