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Ankle Arthrodesis in the Treatment of Neglected Ankle Fractures
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作者 M’bra Kouamé Innocent Krah Koffi Leopold +6 位作者 Kouassi Kouamé Jean-Eric Yao Loukou Blaise Akobé Jean Regis Achie Ochou Pierre Germain Jr Sery Bada Justin Léopold Kouassi Aya Adélaïde Michel Kodo 《Open Journal of Orthopedics》 2022年第4期123-130,共8页
Introduction: Neglected ankle fractures are common in our regions. Patients first consult traditional healers and it is when the signs persist that they consult the surgeon for a swollen and painful ankle. Initially w... Introduction: Neglected ankle fractures are common in our regions. Patients first consult traditional healers and it is when the signs persist that they consult the surgeon for a swollen and painful ankle. Initially we always performed anatomical repairs with osteosynthesis, but the majority of patients still complained of pain and disability. We wondered whether a primary arthrodesis would not be indicated in old ankle fractures to avoid disabling pain for patients. We therefore performed a series of arthrodesis on neglected post-traumatic ankles. The objective of our study was to describe the results of arthrodesis on an old post-traumatic ankle and to propose a therapeutic indication in the face of any neglected ankle fracture. Material and Method: This was a prospective study over 8 years between December 2012 and November 2020, involving 36 cases of neglected ankle fractures treated by arthrodesis using Meary’s technique. We used AOFAS (American Orthopedic Foot and Ankle Score) preoperatively and postoperatively for an objective assessment. Results: The average follow-up was 4.2 years and our results were satisfactory (94.4%) with an average AOFAS score ranging from 27.8 preoperatively to 76.7 postoperatively. The fusion rate was 97.2%. Discussion: Arthrodesis appears here as an important alternative in the treatment of neglected ankle fractures with significant trophic disorders. 展开更多
关键词 ARTHRODESIS ANKLE Neglected Fracture OSTEOSYNTHESIS Traditional healers
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Anemia in Cameroon: A Social Approach
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作者 Kamo Sélangaï Doka Hélène Adamou Moïse +1 位作者 Fadimatou Altine Babba Oumarou 《Open Journal of Pediatrics》 2020年第3期553-560,共8页
Viewed as hidden hunger, anemia is an indicator of poor nutrition and health status, especially for African pre-school children. Several actions are being carried out to combat anemia in Africa, without success. The f... Viewed as hidden hunger, anemia is an indicator of poor nutrition and health status, especially for African pre-school children. Several actions are being carried out to combat anemia in Africa, without success. The fundamental step to improve this situation is to determine 1) mothers’ knowledge regarding anemia (symptoms/signs and etiologies), and 2) their attitudes towards anemia. The present effort was to determine 1) and 2) on mothers (n</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">152) with children (1</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">5 years) through questionnaire. Data showed that the less educated the mother was, the more she gave the wrong definition of anemia. When these mothers have anemic children, 129 go to the hospital, 34 give grenadine (sweet soda), 14 go to the traditional healer, and 6 give the various decoctions. Our results showed that less-educated mothers had wrong anemia management, such as attachment to a visual logic that assimilates blood to food with red coloring. The actions must directly involve these mothers and the traditional healers to improve this situation. 展开更多
关键词 ANEMIA KNOWLEDGE ATTITUDE Child’s Mother Traditional healers
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Utilization of traditional healers for treatment of malaria among female residents in Makurdi city and its environs
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作者 Jombo GTA Mbaawuaga EM +4 位作者 Denen Akaa P Dauda AM Eyong KI Akosu JT Etukumana EA 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第7期563-566,共4页
Objective:To ascertain the role of traditional healers in malaria treatment and its impact on control of the disease.Methods:The study was cross-sectional in nature.Test-run structured and semi-structured questionnair... Objective:To ascertain the role of traditional healers in malaria treatment and its impact on control of the disease.Methods:The study was cross-sectional in nature.Test-run structured and semi-structured questionnaires were either interviewer or self administered to adult women aged 18 years old and above.House holds were selected using systematic random sampling methods.Information such as age,educational level,marital status,occupation and methods of malaria treatment were obtained.Focused group discussions about beliefs and perceptions on utilization of traditional healers and in depth discussions on treatment and control of malaria were also carried out.Results:Of the 2 075 respondents studied,49.7%(n=1 031) utilized traditional healers for treatment of malaria,including 16.7%(n=172) utilizing traditional healers strictly while 83.3%(n=859) combining it with other treatment methods such as hospital/clinic, pharmacy/chemist shop,herbs or spiritual healing.The major contributors to utilization of traditional healers were:illiteracy and ignorance,poverty,unemployment/underemployment and slow pace of the comprehensive package implementation of the "roll back malaria"(RBM) programme initiate in the community.Conclusions:Health education should be intensified while adequate facilities put in place to commence home management of malaria and probable free distribution of the artemisinin-based combination therapy(ACT). 展开更多
关键词 TRADITIONAL healers UTILIZATION MALARIA TREATMENT Adult-women
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Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region(Uttarakhand)Used in the Traditional Medicine for Diabetes by Jaunsari Tribe
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作者 Ankit Kumar Sonali Aswal +3 位作者 Ashutosh Chauhan Ruchi Badoni Semwal Abhimanyu Kumar Deepak Kumar Semwal 《Natural Products and Bioprospecting》 CAS 2019年第3期175-200,共26页
The Himalayan region is the treasure house of natural wealth,particularly of medicinal and aromatic plants.These plants are used by the Indian traditional healers for the past many centuries to treat various ailments ... The Himalayan region is the treasure house of natural wealth,particularly of medicinal and aromatic plants.These plants are used by the Indian traditional healers for the past many centuries to treat various ailments such as skin disorders,asthma,diabetes,snake bite,fever,pain,eye diseases,diarrhoea,indigestion,jaundice,burn,wound,liver disorder,CNS disorders and urinary tract infection.The indigenous traditional knowledge of medicinal plants and therapies of various local communities has been lost due to changes in traditional culture and the introduction of modern technologies.Therefore,it is essential to explore the traditional knowledge of the indigenous medicinal plants mainly in such areas where there is a severe threat to natural vegetation owing to human inhabitation.The present study aimed to explore the medicinal plants of Chakrata region(Jaunsar-Bawar Hills),Uttarakhand,India used in the folk medicine for the management of diabetes by Jaunsari Tribe.In a comprehensive feld survey,the information about the medicinal plants have been mainly collected from the traditional healers and other elderly people belong to the tribal community.All the information about the medicinal plants of the study area was documented in a feld book.Various tools have been used to collect the samples for identifcation purpose and the authentication of the plants was done with the help of taxonomists.The literature on these plants was also searched from online(PubMed and Scopus)as well as from some textbooks and Ayurvedic classical texts.The present survey-based work described a total of 54 plants belonging to 47 genera and 30 families used in the traditional medicine for the management of diabetes in Chakrata region.The information gathered from the local community revealed that the plants are efective in diabetes and one can use most of them without consulting a practitioner or traditional healer.The literature revealed that most of the surveyed plants are already used in the preparation of various antidiabetic formulations s 展开更多
关键词 AYURVEDA DIABETES Herbal formulations Traditional healers Folk medicine
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Local Perceptions on the Status,Values and Conservation and Ethnobotanical Implications of Medicinal and Multipurpose Plants in and Around Selected Church Forests in Central Ethiopia
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作者 Eguale Tadesse 《Research in Ecology》 2020年第3期13-31,共19页
Societies have varied attitude and perception on the forest resources nearby them.Ethnobotanical knowledge should be integrated with biophysical studies in order to be used for managing and conserving forests.The obje... Societies have varied attitude and perception on the forest resources nearby them.Ethnobotanical knowledge should be integrated with biophysical studies in order to be used for managing and conserving forests.The objectives of the study were to assess the existing knowledge about the uses of plant species and to examine the plant species.Three sites were selected around central Ethiopia encompassing three church forests.Focus group discussion,questionnaire-based social survey and vegetation inventory were undertaken.The focus group discussants were selected from traditional healers,elders of the society,development agents,and people who are knowledgeable about the vegetation of the areas.Voucher specimens were collected for those species difficult to identify.The data analysis was done by descriptive statistics using Excel 2010 and SPSS v20.The results indicated agricultural expansion,charcoal making and fuel wood as the major causes of deforestation in Site 1,Site 2 and Site 3 respectively.Religious preaching was stated by group discussants as the most effective solution to reverse the degradation and to protect the church forests.The plant species have varied uses as traditional medicine,food,construction wood,household utensils,and firewood but higher percent of the mentioned species were used either for human or livestock medicine.Sørensen similarity index indicated Site 1 and Site 2 have 12.5%,Site 1 and Site 3 have 10.9%and Site 2 and Site 3 have 43.5%similarities.Documenting the wealth of indigenous knowledge and in situ conservation of the plant species are key recommendations. 展开更多
关键词 Agricultural expansion Plant species Traditional healers Traditional medicine Vegetation inventory
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云南省陇川县景颇族传统医生的现状分析 被引量:6
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作者 成功 龚济达 +2 位作者 薛达元 郭云胶 刘春晖 《云南农业大学学报》 CAS CSCD 北大核心 2013年第2期151-156,共6页
传统医药知识的惠益分享是《生物多样性公约》国际谈判重点,故此迫切需要建立传统医药知识持有人的调查方法。基于已有的调查资料,本研究通过实地作业,采用半结构访谈、问卷调查、参与观察等方法,对陇川县境内的景颇族传统医生进行逐一... 传统医药知识的惠益分享是《生物多样性公约》国际谈判重点,故此迫切需要建立传统医药知识持有人的调查方法。基于已有的调查资料,本研究通过实地作业,采用半结构访谈、问卷调查、参与观察等方法,对陇川县境内的景颇族传统医生进行逐一入户普查,设立了民族传统医生的田野调查操作标准:收费或者有报酬的医疗服务;当地人普遍接受其医疗实践;收藏或种植医疗常用药物。结果表明,陇川县景颇族传统医生在2011年共18人,其中1人为女性;平均年龄为63岁,以高龄为主,最小年龄是40岁;在教育程度上,77%是小学及以下水平;绝大多数景颇族传统医生没有合法的行医身份。笔者认为,需要促进景颇族传统医生的医药理论整理工作。 展开更多
关键词 陇川县 景颇族 传统医生 传统知识
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内蒙古巴林右旗民间蒙医生药用野生植物的初步调查 被引量:5
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作者 孟根其其格 哈斯巴根 《时珍国医国药》 CAS CSCD 北大核心 2012年第3期744-747,共4页
内蒙古巴林右旗6名民间蒙医生所用野生植物共有83种和4变种。民间蒙医生所用植物药以全草类为主,其次为根及根茎类、果实及种子类和花类,对茎木类、皮类及叶类的使用较少。当地民间医生有着选择利用一种植物不同部位的方法。在民间不同... 内蒙古巴林右旗6名民间蒙医生所用野生植物共有83种和4变种。民间蒙医生所用植物药以全草类为主,其次为根及根茎类、果实及种子类和花类,对茎木类、皮类及叶类的使用较少。当地民间医生有着选择利用一种植物不同部位的方法。在民间不同蒙医生之间对当地植物种类的选择药用上有着很大的差异。在蒙药和中草药文献上未见民间蒙医生所药用狭长花沙参、长柱沙参、黑桦、内蒙驼绒藜的药用记载。民间蒙医生对野罂粟、瓣蕊唐松草、香青兰、山楂、藜芦、苍术、并头黄芩、菟丝子、斑叶堇菜、小叶锦鸡儿、油松、山丹药用部位的选择与中草药和蒙药学的记载不相同。 展开更多
关键词 巴林右旗 民间蒙医生 野生植物 药用
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内蒙古克什克腾旗蒙古族民间医生药用野生植物的初步调查 被引量:1
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作者 依如贵 哈斯巴根 《时珍国医国药》 CAS CSCD 北大核心 2017年第5期1204-1206,共3页
克什克腾旗蒙古族民间医生从当地采集的药用植物共有42种、2变种,隶属24科40属。所用的药用植物在药用部位的选择上以花类为主,全部种类中有4种植物有2~3个不同的药用部位。未见百里香Thymus serpyllum的药用记载。
关键词 克什克腾旗 蒙古族民间医生 野生植物 药用
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复合乳酸菌片联合蒙脱石散对腹泻患儿免疫功能的影响
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作者 宋中福 《现代诊断与治疗》 CAS 2018年第2期174-177,共4页
目的探讨复合乳酸菌片联合蒙脱石散对腹泻患儿免疫功能的影响。方法通过随机数字表的方法选择200例于2013年1月~2015年6月在我院儿科治疗小儿腹泻患儿作为研究对象并对其进行分组,所有患儿均采取相同的方案实施止泻、抗感染及对症支持治... 目的探讨复合乳酸菌片联合蒙脱石散对腹泻患儿免疫功能的影响。方法通过随机数字表的方法选择200例于2013年1月~2015年6月在我院儿科治疗小儿腹泻患儿作为研究对象并对其进行分组,所有患儿均采取相同的方案实施止泻、抗感染及对症支持治疗,观察组患儿另加用复合乳酸菌片进行治疗,观察治疗前后症状改善情况,记录大便次数复常时间、大便性状复常时间,空腹抽血检测免疫球蛋白(Ig A、Ig G),评价两组临床疗效,统计随访6、12个月腹泻复发次数。结果观察组100例中显效78例(78.0%),总有效率92.0%(92/100);对照组100例中显效52例(52.0%),总有效率87.0%(87/100);两组疗效比较,差异有统计学意义(χ2=6.664,P<0.05);观察组患者治疗后大便次数复常时间、大便性状复常时间明显低于对照组,且比较差异有统计学意义(P<0.05);观察组患者6个月复发次数、12个月复发次数均明显少于对照组,且比较差异有统计学意义(P<0.05);观察组患者治疗后Ig A、Ig G均明显高于治疗前,且比较差异有统计学意义(P<0.05);对照组患者治疗后Ig A、Ig G均明显高于治疗前,且比较差异有统计学意义(P<0.05);观察组患者治疗后Ig A、Ig G均明显高于对照组治疗后,且比较差异有统计学意义(P<0.05);观察组不良反应发生率为4.0%(4/100),对照组发生率为7.0(7/100)。2组不良反应发生率比较,差异无统计学意义(χ2=0.519,P>0.05)。结论小儿腹泻治疗中应用复合乳酸菌片和蒙脱石散治疗,能够提高患儿免疫力,有利于患儿早期康复,减少各种不良事件的发生几率。 展开更多
关键词 小儿腹泻 传统治疗 复合乳酸菌片 蒙脱石散
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建构与层累:汉末以来董奉形象变化考述
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作者 吴志远 李孟霞 蔡杰 《重庆大学学报(社会科学版)》 北大核心 2024年第3期180-191,共12页
董奉是一位汉魏之交长期活动于江南一带的民间巫师,在庐山归隐终老后,被后世塑造成一位道教仙人的形象,与华佗、张仲景并称“建安三神医”,其标志性符号有“福山”“杏林”等。然而,董奉的形象并非一直以“神医”得以彰显,而是经历了从... 董奉是一位汉魏之交长期活动于江南一带的民间巫师,在庐山归隐终老后,被后世塑造成一位道教仙人的形象,与华佗、张仲景并称“建安三神医”,其标志性符号有“福山”“杏林”等。然而,董奉的形象并非一直以“神医”得以彰显,而是经历了从神仙到神医的转变。自汉末以来,董奉的人物形象经历了三次建构:从葛洪《神仙传》中的道教仙人形象记载,到唐宋时期对其仙人身份的官方敕封和道教徒推广,再到元代以后逐渐由文人士大夫对其医者形象的再次书写,董奉的形象经历了民间巫祝—官封神灵—仁心良医的转变。董奉形象的第一次建构缘于早期道教争取官方与民间支持的发展策略筹划;第二次建构则缘于唐宋时期国家意志与地方传统结合下地方宗教对合法获得收益与支持的认识实践方式;第三次重构的原因主要是元明时期医者地位的提升,以及文人士大夫赞誉医者或借喻标榜自身德行的儒医结合倾向的具体表现。但在这几次形象建构中,董奉的超自然属性没有随着时间的推进而有新的神迹,而且因后人加注而屡遭失载,进而限制了董奉信仰的广泛流传。经过这三次人物形象建构后,与华佗、张仲景不同,董奉在元代之后甚至未成为十大名医配飨三皇。而民间、官方对董奉的态度,也从魏晋时期的民间崇拜,至唐宋时期官方认可并大加敕封,南宋后已变为“事迹失注”,最终成为元以来文人士大夫赠答歌颂的良医标杆,并被固定下来至今日。在董奉人物形象的塑造过程中,完成了从神仙到神医的转变,体现了历史人物建构的复杂过程。 展开更多
关键词 董奉 人物形象 道教仙人 良医
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煤质分析仪加热炉温度场分析及ANSYS模拟 被引量:4
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作者 陈刚 朱石沙 《湘潭大学自然科学学报》 CAS CSCD 北大核心 2006年第1期89-92,共4页
依据GB/T212-2001提出一种可以提高煤(焦)质检测速度的煤质分析仪加热炉设计,对该加热炉进行了温度场分析,并通过ANSYS软件进行了模拟.通过分析的结果认为这种加热炉的设计满足快速检测的要求,为煤(焦)质快速分析仪的研制提供了理论指导.
关键词 加热炉 温度场 ANSYS
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Folk-beliefs and Folk-healing in Rural Turkey
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作者 Sinan Caya 《Journal of Health Science》 2015年第1期42-52,共11页
Peasants in Turkey are mostly wise, worldly, down-to-earth people. Superstitions do play a role in their line of thinking though it is not only the peasant mind which is exclusively preoccupied with superstitions. Pea... Peasants in Turkey are mostly wise, worldly, down-to-earth people. Superstitions do play a role in their line of thinking though it is not only the peasant mind which is exclusively preoccupied with superstitions. Peasants' other beliefs mostly fall into the scope of religious creed. Folk healing is mingled with some beliefs but some healing methods are just primitive but consistently logical modes of treatment of diseases and if people resort to them, it is mainly because of the inaccessibility of modem medical ways. Folk healing, besides, is being replaced by modem treatment more and more. 展开更多
关键词 BELIEF ISLAM healer FOLK PEASANT Turkish.
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注册表工具篇
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《软件世界(PC任我行)》 2003年第4期13-15,共3页
当我们致力于修改注册表的时候,也同样需要借助一些工具软件的帮助,这一点一定要注意,它可以帮助我们完成一些看似负责的问题,下面就来看看一些常用的注册表工具软件是如何运作的。
关键词 注册表 REGCLEANER 键盘操作 批处理 “Registry healer Regsnap REGMON
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How to Become a Good Healer in Chinese Medicine?
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作者 Udo Lorenzen 《Chinese Medicine and Culture》 2020年第1期44-46,共3页
Today,traditional Chinese medicine(TCM)is a relatively new product of the People’s Republic of China.About 1950 Chairman Mao aimed atthe standardization and simplification of many traditional medical schools to guara... Today,traditional Chinese medicine(TCM)is a relatively new product of the People’s Republic of China.About 1950 Chairman Mao aimed atthe standardization and simplification of many traditional medical schools to guarantee a stable health care for the population.As academic exchange between east and west increased during the last 60 years,TCM appears today more and more as the“real”and“old”Chinese medicine.But is that really the case?There is a famous saying in China:Medicine is also idea(医者意也Yi Zhe Yi Ye),so what are the ideas about a good healer?In my article I try to find it out.Searching through the old classical books,there are some good ideas about a good healer,especially in the Ling Shu(《灵枢》Spiritual Pivot).The root of all is the spirit(神Shen).There are many other requirements to be a good healer,but without a stable Shen,no treatment can really touches the cause of the disease! 展开更多
关键词 Acupuncture and moxibustion Chinese medicine healer
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论古代中国名医的人文精神
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作者 冯雪梅 温瑞 《中国多媒体与网络教学学报(电子版)》 2018年第1期320-322,共3页
人文精神是医学的核心价值。但是随着现代社会发展,医学的人文精神正在逐渐丧失。学习中国古代医者身上闪耀的人文精神,如仁爱之心、命比金贵、不问贵贱等,有助于重振现代医学的人文精神,也有利于缓解日益紧张的医患关系。
关键词 人文精神 医者 仁爱之心 现实价值
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提高YJP-Q系列车用液体加热器热效率的试验研究
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作者 郭彬 江楠 +2 位作者 毛华永 郭烽 郭玉龙 《内燃机》 2012年第6期33-36,共4页
为提高车用液体加热器的热效率,设计了双水腔换热器和双面燃气加热换热器。经台架试验,二者的热效率比原机有大幅提高,而排气温度大幅下降;还对燃烧室燃气回流罩位置及水流量对加热器热效率的影响进行了试验研究。
关键词 加热器 换热器 热效率
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Sight Healer
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作者 CHEN SHANSHAN 《Women of China》 1999年第10期13-15,共3页
IN ancient Greek mythology, Prometheusfetches fire from the heavens and bringslight to mankind. Today it is theophthalmologists who are using their skills tobring light to the unsighted - thePrometheus’ of the 20th c... IN ancient Greek mythology, Prometheusfetches fire from the heavens and bringslight to mankind. Today it is theophthalmologists who are using their skills tobring light to the unsighted - thePrometheus’ of the 20th century. Dr. LiXiaoxin from the People’s Hospital attachedto the Beijing Academy of Medical Sciencesis one such person whose torch shinesespecially brightly. Zhao Yunxia, with the Lanzhou ChemicalIndustrial Company, will never forget the dayof May 23, 1990. An accident caused seriousinjury to her face and left her badly scarred. 展开更多
关键词 LI Sight healer
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阅读疗愈师的职业属性、工作模式与专业胜任力研究——基于《阅读疗愈师》的评鉴与思考 被引量:5
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作者 王景文 刘洋 李杏丽 《国家图书馆学刊》 CSSCI 北大核心 2022年第3期51-61,共11页
阅读疗愈师在我国是一个新兴职业,无论是理论探索还是实践积累均十分薄弱。其职业实践尚缺乏统一的规范与标准,处于边学习、边摸索、边实践状态,且学界对阅读疗愈师职业的研究重视不够,主要表现为研究成果少,缺乏聚焦阅读疗愈师主题的... 阅读疗愈师在我国是一个新兴职业,无论是理论探索还是实践积累均十分薄弱。其职业实践尚缺乏统一的规范与标准,处于边学习、边摸索、边实践状态,且学界对阅读疗愈师职业的研究重视不够,主要表现为研究成果少,缺乏聚焦阅读疗愈师主题的系统研究。《阅读疗愈师》作为一部专门描述阅读疗愈师职业活动的作品,系统、完整地塑造了一个典型的阅读疗愈师形象,使我们得以管窥阅读疗愈师的职业属性、工作模式以及专业胜任力构成等,这对我国阅读疗愈师研究与实践具有重要启示。图2。表2。参考文献22。 展开更多
关键词 阅读疗愈师 职业属性 工作模式 专业胜任力
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清代吴中女医顾德华考略 被引量:4
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作者 林振坤 宋文集 《中华医史杂志》 CAS 2016年第5期272-278,共7页
女医是传统中国医疗从业人员的特殊群体,一方面宋元以来掌握社会话语权的士人阶层,和以医学正统自居的男性医者,常常通过各种媒介方式,表达对女医道德、技术水平的质疑,并使其形象不断负面化;而另一方面,基于12世纪宋明理学兴起后男女... 女医是传统中国医疗从业人员的特殊群体,一方面宋元以来掌握社会话语权的士人阶层,和以医学正统自居的男性医者,常常通过各种媒介方式,表达对女医道德、技术水平的质疑,并使其形象不断负面化;而另一方面,基于12世纪宋明理学兴起后男女有别的意识形态,社会一直对于女医及其服务存在现实的强大需求,一位优秀的女医仍可以获得社会的广泛尊重.顾德华是清代的一位著名女医.通过对其家世、事迹与著作的初步考证,可以增进对这位清代著名女医的了解,并借此窥视明清社会中女医这一群体的相关情况. 展开更多
关键词 女医 顾德华 韦君绣 《花韵楼诗稿》 《花韵楼医案》
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硝酸酯类药对大鼠蛛网膜下腔出血后脑血管痉挛影响的研究 被引量:4
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作者 陈旭 李光来 +1 位作者 张波 黄立坤 《中国脑血管病杂志》 CAS 2005年第4期160-164,共5页
目的探讨硝酸酯类药物对蛛网膜下腔出血(SAH)大鼠脑血管平滑肌内一氧化氮含量、脑动脉痉挛以及缺血性脑损伤的影响。方法采用自体动脉血注入大鼠枕大池的方法制备SAH模型。将36只雄性Wistar大鼠随机分为4组,每组9只。A组正常组;B组SAH... 目的探讨硝酸酯类药物对蛛网膜下腔出血(SAH)大鼠脑血管平滑肌内一氧化氮含量、脑动脉痉挛以及缺血性脑损伤的影响。方法采用自体动脉血注入大鼠枕大池的方法制备SAH模型。将36只雄性Wistar大鼠随机分为4组,每组9只。A组正常组;B组SAH组;C组SAH给予尼莫地平组;D组SAH给予单硝酸异山梨酯组。利用多普勒超声观察各模型组的脑动脉血流量,检测大鼠脑动脉组织匀浆内的一氧化氮浓度,一氧化氮合酶(NOS)、环磷酸鸟苷(cGMP)含量,观察海马角神经元的超微结构及BAX、BCL2阳性细胞表达的数量。结果①单硝酸异山梨酯与尼莫地平一样,均可降低大鼠脑血管阻力,改善SAH所致的脑血管痉挛。②D组的一氧化氮含量明显高于其他组(P<0.05)。③D组大鼠的cGMP含量为(225±45)pmol/ml,B组为(108±31)pmol/ml,C组为(112±29)pmol/ml,与D组比较,均P<0.05;A组为(211±45)pmol/ml,与D组比较,差异无显著意义(P>0.05)。④BAX阳性细胞数的变化A组为0.30±0.03,D组为0.50±0.04,C组为0.57±0.07,B组为0.67±0.05。结论硝酸酯类药物通过NOcGMP血管舒张通路,以解除SAH后的脑血管痉挛,而改善脑血流量。 展开更多
关键词 脑血管痉挛 影响的研究 蛛网膜下腔出血(SAH) 一氧化氮合酶(NOS) 环磷酸鸟苷(cGMP) 单硝酸异山梨酯 Wistar大鼠 一氧化氮含量 硝酸酯类药物 NO-CGMP 药对 缺血性脑损伤 一氧化氮浓度 CGMP含量 尼莫地平 0.05 脑动脉痉挛
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