本文借助软件Word Smith Tools 6.0,从数量、频次和分布这三个方面出发,对初中英语教材Go for it中的搭配进行了分析。研究发现:(1)Go for it中的搭配数量满足课程标准的要求;(2)低频搭配数量多。教材中共有154个搭配出现在6次以下,占...本文借助软件Word Smith Tools 6.0,从数量、频次和分布这三个方面出发,对初中英语教材Go for it中的搭配进行了分析。研究发现:(1)Go for it中的搭配数量满足课程标准的要求;(2)低频搭配数量多。教材中共有154个搭配出现在6次以下,占总数的73.7%;(3)分布在各年级教材中的搭配在数量上没有显著性差异。但当考虑到搭配分布和频次关系的时候,研究发现有的搭配尽管出现频次高,分布范围却很窄。展开更多
The number of available protein sequences in public databases is increasing exponentially.However,a sig-nificant percentage of these sequences lack functional annotation,which is essential for the understanding of how...The number of available protein sequences in public databases is increasing exponentially.However,a sig-nificant percentage of these sequences lack functional annotation,which is essential for the understanding of how bio-logical systems operate.Here,we propose a novel method,Quantitative Annotation of Unknown STructure(QAUST),to infer protein functions,specifically Gene Ontology(GO)terms and Enzyme Commission(EC)numbers.QAUST uses three sources of information:structure information encoded by global and local structure similarity search,biological network information inferred by protein–protein interaction data,and sequence information extracted from functionally discriminative sequence motifs.These three pieces of information are combined by consensus averaging to make the final prediction.Our approach has been tested on 500 protein targets from the Critical Assessment of Functional Annotation(CAFA)benchmark set.The results show that our method provides accurate functional annotation and outperforms other prediction methods based on sequence similarity search or threading.We further demonstrate that a previously unknown function of human tripartite motif-containing 22(TRIM22)protein predicted by QAUST can be experimentally validated.展开更多
There is a common sense that heavy-duty CNC machine strongly depends on its foundation and can be easily affected by many factors.Hydraulic system,the most important part in CNC machine,is a complex and multi-loop sys...There is a common sense that heavy-duty CNC machine strongly depends on its foundation and can be easily affected by many factors.Hydraulic system,the most important part in CNC machine,is a complex and multi-loop system.In order to make up for the shortcomings of traditional fault tree analysis method and traditional GO method,the most effective method named fuzzy GO method is proposed to analyze the reliability of hydraulic system.And then some ideas are provided for system reliability assessment,fault diagnosis and maintenance by qualitative and quantitative analysis.展开更多
文摘本文借助软件Word Smith Tools 6.0,从数量、频次和分布这三个方面出发,对初中英语教材Go for it中的搭配进行了分析。研究发现:(1)Go for it中的搭配数量满足课程标准的要求;(2)低频搭配数量多。教材中共有154个搭配出现在6次以下,占总数的73.7%;(3)分布在各年级教材中的搭配在数量上没有显著性差异。但当考虑到搭配分布和频次关系的时候,研究发现有的搭配尽管出现频次高,分布范围却很窄。
基金supported by the King Abdullah University of Science and Technology(KAUST)Office of Sponsored Research(OSR)(Grant Nos.URF/1/1976-04,URF/1/1976-06)。
文摘The number of available protein sequences in public databases is increasing exponentially.However,a sig-nificant percentage of these sequences lack functional annotation,which is essential for the understanding of how bio-logical systems operate.Here,we propose a novel method,Quantitative Annotation of Unknown STructure(QAUST),to infer protein functions,specifically Gene Ontology(GO)terms and Enzyme Commission(EC)numbers.QAUST uses three sources of information:structure information encoded by global and local structure similarity search,biological network information inferred by protein–protein interaction data,and sequence information extracted from functionally discriminative sequence motifs.These three pieces of information are combined by consensus averaging to make the final prediction.Our approach has been tested on 500 protein targets from the Critical Assessment of Functional Annotation(CAFA)benchmark set.The results show that our method provides accurate functional annotation and outperforms other prediction methods based on sequence similarity search or threading.We further demonstrate that a previously unknown function of human tripartite motif-containing 22(TRIM22)protein predicted by QAUST can be experimentally validated.
文摘There is a common sense that heavy-duty CNC machine strongly depends on its foundation and can be easily affected by many factors.Hydraulic system,the most important part in CNC machine,is a complex and multi-loop system.In order to make up for the shortcomings of traditional fault tree analysis method and traditional GO method,the most effective method named fuzzy GO method is proposed to analyze the reliability of hydraulic system.And then some ideas are provided for system reliability assessment,fault diagnosis and maintenance by qualitative and quantitative analysis.
