A linear-correction least-squares（LCLS） estimation procedure is proposed for geolocation using frequency difference of arrival （FDOA） measurements only. We first analyze the measurements of FDOA, and further deriv...A linear-correction least-squares（LCLS） estimation procedure is proposed for geolocation using frequency difference of arrival （FDOA） measurements only. We first analyze the measurements of FDOA, and further derive the Cramer-Rao lower bound （CRLB） of geoloeation using FDOA measurements. For the localization model is a nonlinear least squares（LS） estimator with a nonlinear constrained, a linearizing method is used to convert the model to a linear least squares estimator with a nonlinear con- strained. The Gauss-Newton iteration method is developed to conquer the source localization problem. From the analysis of solving Lagrange multiplier, the algorithm is a generalization of linear-correction least squares estimation procedure under the condition of geolocation using FDOA measurements only. The algorithm is compared with common least squares estimation. Comparisons of their estimation accuracy and the CRLB are made, and the proposed method attains the CRLB. Simulation re- sults are included to corroborate the theoretical development.展开更多
目的构建具有最优房室选择机制的药代动力学软件分析系统。方法首先,运用残数法对拟分析的血药浓度序列进行阶数递增的房室模型拟合,在此基础上,根据拟合结果自动确定最优的房室数量;然后,基于Gauss-Newton迭代法估计最优房室模型的参数...目的构建具有最优房室选择机制的药代动力学软件分析系统。方法首先,运用残数法对拟分析的血药浓度序列进行阶数递增的房室模型拟合,在此基础上,根据拟合结果自动确定最优的房室数量;然后,基于Gauss-Newton迭代法估计最优房室模型的参数;最后,采用F检验法验证最优房室模型的有效性和可信性;新系统的编程工具为Microsoft Visual Studio 2015的C++语言。结果实例表明新研制的系统可准确析出最优的房室数量,并精确计算出对应的药代动力学参数。结论新研制的系统具有操作简便和计算准确的特点,且可对药物的代谢过程进行高效建模与分析,从而有效降低药物工作者的劳动强度及提升工作效能。展开更多
基金National High-tech Research and Development Program of China (2011AA7072043)National Defense Key Laboratory Foundation of China (9140C860304)Innovation Fund of Graduate School of NUDT (B120406)
文摘A linear-correction least-squares（LCLS） estimation procedure is proposed for geolocation using frequency difference of arrival （FDOA） measurements only. We first analyze the measurements of FDOA, and further derive the Cramer-Rao lower bound （CRLB） of geoloeation using FDOA measurements. For the localization model is a nonlinear least squares（LS） estimator with a nonlinear constrained, a linearizing method is used to convert the model to a linear least squares estimator with a nonlinear con- strained. The Gauss-Newton iteration method is developed to conquer the source localization problem. From the analysis of solving Lagrange multiplier, the algorithm is a generalization of linear-correction least squares estimation procedure under the condition of geolocation using FDOA measurements only. The algorithm is compared with common least squares estimation. Comparisons of their estimation accuracy and the CRLB are made, and the proposed method attains the CRLB. Simulation re- sults are included to corroborate the theoretical development.
文摘目的构建具有最优房室选择机制的药代动力学软件分析系统。方法首先,运用残数法对拟分析的血药浓度序列进行阶数递增的房室模型拟合,在此基础上,根据拟合结果自动确定最优的房室数量;然后,基于Gauss-Newton迭代法估计最优房室模型的参数;最后,采用F检验法验证最优房室模型的有效性和可信性;新系统的编程工具为Microsoft Visual Studio 2015的C++语言。结果实例表明新研制的系统可准确析出最优的房室数量,并精确计算出对应的药代动力学参数。结论新研制的系统具有操作简便和计算准确的特点,且可对药物的代谢过程进行高效建模与分析,从而有效降低药物工作者的劳动强度及提升工作效能。
