目的比较视神经脊髓炎和其他疾病脑脊液及血清的氯化物比值,探讨视神经脊髓炎可能的病理机制.方法回顾性分析75例至少进行过一次血清和脑脊液配对检查的患者,分为视神经脊髓炎(N M O)、控制组(非感染性疾病)、周围神经病、中枢神经系统...目的比较视神经脊髓炎和其他疾病脑脊液及血清的氯化物比值,探讨视神经脊髓炎可能的病理机制.方法回顾性分析75例至少进行过一次血清和脑脊液配对检查的患者,分为视神经脊髓炎(N M O)、控制组(非感染性疾病)、周围神经病、中枢神经系统感染组,重点对比氯的商数(CSF水平/血清水平,QCl),并同时对比白蛋白、葡萄糖的商数及其脑脊液细胞数等指标.结果视神经脊髓炎患者QCl较对照组差异有统计学意义(P<0.01),与其他疾病比较差异有统计学意义(P<0.05),除QCl以外的其他指标与对照组差异无统计学意义(P>0.05).其他疾病的QCl与对照组差异无统计学意义(P>0.05).周围神经炎症组及中枢神经系统感染组QCl较对照组差异无统计学意义(P>0.05).中枢神经系统感染组脑脊液细胞数较对照组差异有统计学有意义(P<0.05),年龄、性别、QCl与NMO阳性有回归关系.NMO阳性与QCl有强烈的相关性,血及脑脊液的其他指标未显示出相关性.结论氯失衡是视神经脊髓炎较为特异的表现,并可能反映了其病理机制.展开更多
Nowadays,fluid resuscitation of multiple trauma patients is still a challenging therapy.Existing therapies for volume replacement in severe haemorrhagic shock can lead to adverse reactions that may be fatal for the pa...Nowadays,fluid resuscitation of multiple trauma patients is still a challenging therapy.Existing therapies for volume replacement in severe haemorrhagic shock can lead to adverse reactions that may be fatal for the patient.Patients presenting with multiple trauma often develop hemorrhagic shock,which triggers a series of metabolic,physiological and cellular dysfunction.These disorders combined,lead to complications that significantly decrease survival rate in this subset of patients.Volume and electrolyte resuscitation is chal enging due to many factors that overlap.Poor management can lead to post-resuscitation systemic inflammation causing multiple organ failure and ultimately death.In literature,there is no exact formula for this purpose,and opinions are divided.This paper presents a review of modern techniques and current studies regarding the management of fluid resuscitation in trauma patients with hemorrhagic shock.According to the literature and from clinical experience,al aspects regarding post-resuscitation period need to be considered.Also,for every case in particular,emergency therapy management needs to be rigorously respected considering al physiological,biochemical and biological parameters.展开更多
文摘目的比较视神经脊髓炎和其他疾病脑脊液及血清的氯化物比值,探讨视神经脊髓炎可能的病理机制.方法回顾性分析75例至少进行过一次血清和脑脊液配对检查的患者,分为视神经脊髓炎(N M O)、控制组(非感染性疾病)、周围神经病、中枢神经系统感染组,重点对比氯的商数(CSF水平/血清水平,QCl),并同时对比白蛋白、葡萄糖的商数及其脑脊液细胞数等指标.结果视神经脊髓炎患者QCl较对照组差异有统计学意义(P<0.01),与其他疾病比较差异有统计学意义(P<0.05),除QCl以外的其他指标与对照组差异无统计学意义(P>0.05).其他疾病的QCl与对照组差异无统计学意义(P>0.05).周围神经炎症组及中枢神经系统感染组QCl较对照组差异无统计学意义(P>0.05).中枢神经系统感染组脑脊液细胞数较对照组差异有统计学有意义(P<0.05),年龄、性别、QCl与NMO阳性有回归关系.NMO阳性与QCl有强烈的相关性,血及脑脊液的其他指标未显示出相关性.结论氯失衡是视神经脊髓炎较为特异的表现,并可能反映了其病理机制.
基金The authors have deeply grateful to Emergency County Hospital"Pius Brinzeu"for full support of this article
文摘Nowadays,fluid resuscitation of multiple trauma patients is still a challenging therapy.Existing therapies for volume replacement in severe haemorrhagic shock can lead to adverse reactions that may be fatal for the patient.Patients presenting with multiple trauma often develop hemorrhagic shock,which triggers a series of metabolic,physiological and cellular dysfunction.These disorders combined,lead to complications that significantly decrease survival rate in this subset of patients.Volume and electrolyte resuscitation is chal enging due to many factors that overlap.Poor management can lead to post-resuscitation systemic inflammation causing multiple organ failure and ultimately death.In literature,there is no exact formula for this purpose,and opinions are divided.This paper presents a review of modern techniques and current studies regarding the management of fluid resuscitation in trauma patients with hemorrhagic shock.According to the literature and from clinical experience,al aspects regarding post-resuscitation period need to be considered.Also,for every case in particular,emergency therapy management needs to be rigorously respected considering al physiological,biochemical and biological parameters.
