摘要
目的探讨高渗复合液对创伤性休克患者复苏早期氧供需失衡的影响。方法将60例创伤性休克患者随机分成两组，各30例。A组：选择限制性液体复苏疗法，采用高渗复合液（贺苏）进行复苏；B组：选择传统液体复苏疗法，采用等渗液“复方氯化钠注射液”进行复苏。观察记录两组用药前及用药2h后静脉血氧饱和度（SvO2）、血细胞比容（HCT）、血乳酸（Lac）、碱缺失（BD），治疗终点死亡率和多器官功能障碍综合征（MODS）发生率，并进行比较分析。结果两组在治疗前SvO2、Lac、HCT及BD等指标间比较差异无统计学意义（P〉0．05）。治疗2h后，与B组比较，A组SvO2明显上升，Lac、BD明显下降；两组HCT均有所下降，但B组尤为明显，差异有统计学意义（P〈0．01）。病程终点死亡率：A组3．33％，B组13．33％；MODS发生率：A组20％，B组60％；两组比较差异均有统计学意义（P〈0．05）。结论与等渗液比较，高渗复合液对创伤性休克复苏效率高，而且能明显改善氧供需失衡，可作为创伤性休克复苏早期首选。
Objective To investigate the hypertonic solution improves early recovery of traumatic shock effect of oxygen supply and demand imbalance. Methods 60 patients with traumatic shock were randomly divided into 2 groups, all 30 cases. A group： Select fluid resuscitation therapy, combined with hypertonie resuscitation fluid for Ho Su; B group： choice of traditional fluid resuscitation therapy, such as exudate compound with sodium chloride injection to recovery. Observed and recorded 2 groups before treatment and after 2 hours SvO2 （ venous oxygen saturation ）, HCT （ hematocrit）, Lae （lactate）, BD （base deficit）, the treatment end point mortality and MODS （multiple organ dysfunction syndrome） incidence, and comparative analysis. Results Before treatment SvO2, Lac, HCT, BD and other indicators showed no significant difference between （ P 〉 0.05 ）. 2 hours after treatment, compared with B, A marked increase in group SvO2 ; Lac, BD decreased significantly ; two groups has declined HCT, but especially B group; a highly significant difference （P 〈0.01 ）. Disease mortality end point： A group 3. 33%, B group 13. 33% ; MODS rate： A group 20%, B group 60% ; difference was statistically significant （ P 〈 0. 05 ）, Conclusion Compared with other exudate, hypertonic solution improves efficiency of traumatic shock resuscitation, and can significantly improve the oxygen supply and demand imbalance, can be used as an early choice for traumatic shock resuscitation.
出处
《中国急救医学》
CAS
CSCD
北大核心
2011年第10期920-923,共4页
Chinese Journal of Critical Care Medicine
关键词
创伤性休克
限制性液体复苏
高渗复合液
氧供需失衡
Traumatic shock
Limited fluid resuscitation
Hypertonic complex liquid
Imbalance between oxygen supply and demand
