AIM: To determine whether Helicobacter pylori (H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease (NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectivel...AIM: To determine whether Helicobacter pylori (H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease (NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectively. Inclusion criteria were age ≥ 20 years, history of H. pylori infection, and recorded insulin level. Participants were classified as H. pylori positive or negative according to <sup>13</sup>C urea breath tests. NAFLD was defined using the hepatic steatosis index (HSI) and NAFLD liver fat score (NAFLD-LFS). Those with an HSI > 36 or NAFLD-LFS > -0.640 were considered to have NAFLD. Multivariable logistic regression was performed to identify risk factors for NAFLD.RESULTS: Three thousand six hundred and sixty-three people were analyzed and 1636 (44.7%) were H. pylori positive. H. pylori infection was associated with older age, male gender, hypertension, higher body mass index, and a dyslipidemic profile. HSI differed significantly between H. pylori positive and negative subjects (median 33.2, interquartile range (IQR) 30.0-36.2 for H. pylori-positive vs median 32.6, IQR 29.8-36.0 for negative participants, P = 0.005), but NAFLD-LSF did not [median -1.7, IQR -2.4 - -0.7 vs median -1.8, IQR -2.4-(-0.7), respectively, P = 0.122]. The percentage of people with NAFLD did not differ between infected and uninfected groups: HIS, 26.9% vs 27.1%, P = 0.173; NAFLD-LFS, 23.5% vs 23.1%, P = 0.778. H. pylori infection was not a risk factor, but C-reactive protein concentration and smoking were significant risk factors for NAFLD.CONCLUSION: H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered.展开更多
Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly characterized.Accurate characterization of the genetic background of hepatic fat content would provide insights into disea...Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly characterized.Accurate characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk factors.We performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and APOE.GWAS of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between MRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MRI-PDFF genetic signals(CREB3L1 and GCM1)were replicated in the FLI GWAS.We identified two novel genes for MRI-PDFF and 49 replicable loci for FLI.Despite a difference in hepatic fat content assessment between MRI-PDFF and FLI,a substantial similar genetic architecture was found.FLI is identified as an easy and reliable approach to study hepatic fat content at the population level.展开更多
Nonalcoholic fatty liver disease(NAFLD)is strongly associated with the metabolic syndrome and type 2 diabetes and independently contributes to long-term complications.Being often asymptomatic but reversible,it would r...Nonalcoholic fatty liver disease(NAFLD)is strongly associated with the metabolic syndrome and type 2 diabetes and independently contributes to long-term complications.Being often asymptomatic but reversible,it would require population-wide screening,but direct diagnostics are either too invasive(liver biopsy),costly(MRI)or depending on the examiner’s expertise(ultrasonography).Hepatosteatosis is usually accommodated by features of the metabolic syndrome(e.g.obesity,disturbances in triglyceride and glucose metabolism),and signs of hepatocellular damage,all of which are reflected by biomarkers,which poorly predict NAFLD as single item,but provide a cheap diagnostic alternative when integrated into composite liver fat indices.Fatty liver index,NAFLD LFS,and hepatic steatosis index are common and accurate indices for NAFLD prediction,but show limited accuracy for liver fat quantification.Other indices are rarely used.Hepatic fibrosis scores are commonly used in clinical practice,but their mandatory reflection of fibrotic reorganization,hepatic injury or systemic sequelae reduces sensitivity for the diagnosis of simple steatosis.Diet-induced liver fat changes are poorly reflected by liver fat indices,depending on the intervention and its specific impact of weight loss on NAFLD.This limited validity in longitudinal settings stimulates research for new equations.Adipokines,hepatokines,markers of cellular integrity,genetic variants but also simple and inexpensive routine parameters might be potential components.Currently,liver fat indices lack precision for NAFLD prediction or monitoring in individual patients,but in large cohorts they may substitute nonexistent imaging data and serve as a compound biomarker of metabolic syndrome and its cardiometabolic sequelae.展开更多
该文旨在研究初始脂肪含量、贮存温度对超高温灭菌(ultra high temperature sterilized,UHT)牛奶贮存期间的品质变化及货架期影响规律。对23、30、37℃无光照贮存过程中不同初始脂肪含量UHT纯牛奶的色泽、蛋白水解度、羰基含量进行分析...该文旨在研究初始脂肪含量、贮存温度对超高温灭菌(ultra high temperature sterilized,UHT)牛奶贮存期间的品质变化及货架期影响规律。对23、30、37℃无光照贮存过程中不同初始脂肪含量UHT纯牛奶的色泽、蛋白水解度、羰基含量进行分析,比较各指标对感官评分的Pearson系数,应用Arrhenius方程等建立货架期预测模型。随着贮存时间的延长、贮存温度的升高,样品的褐变指数、蛋白水解度、羰基含量均随之提高,而感官评分值降低;将感官评分和其他指标进行Pearson相关性分析筛选出褐变指数作为反映其品质变化的关键指标,建立基于初始脂肪含量和贮存温度影响的货架期预测模型,模型预测值与实际货架期验证比较,相对误差小于10%。所建预测模型可有效预测无光照下不同初始脂肪含量UHT牛奶货架期。展开更多
目的探讨绝经后女性各部位脂肪指数与骨密度(bone mineral density,BMD)的相关性。方法收集自2019年6月至2020年11月在昆山市中医医院体检中心体检的1229例绝经后妇女的BMD数据(包括L_(1~4)、全髋关节、股骨颈),同时收集身体各部位的脂...目的探讨绝经后女性各部位脂肪指数与骨密度(bone mineral density,BMD)的相关性。方法收集自2019年6月至2020年11月在昆山市中医医院体检中心体检的1229例绝经后妇女的BMD数据(包括L_(1~4)、全髋关节、股骨颈),同时收集身体各部位的脂肪指数数据,按身体质量指数(body mass index,BMI)分为:体重正常组(18.5 kg/m^(2)≤BMI<24 kg/m^(2))和体重超重组(BMI≥24 kg/m^(2))。正常组526例,年龄48~91岁,平均年龄(65.43±9.14)岁。超重组703例,年龄48~86岁,平均年龄(65.33±8.58)岁。通过单因素方差分析以及多元回归分析,探讨绝经后女性各部位脂肪指数与BMD的相关性。结果超重组L_(1~4)BMD、股骨颈BMD及全髋关节BMD均高于体重正常组(P<0.001)。超重组L_(1~4)BMD与全身脂肪指数呈负相关(P<0.001),与Android脂肪指数呈正相关(P<0.001);全髋关节BMD与全身脂肪指数负相关(P=0.006);股骨颈BMD与全身各部位脂肪指数无显著相关性(P>0.05)。体重正常组L_(1~4)BMD与全身脂肪指数呈负相关(P=0.016),与躯干脂肪指数呈正相关(P<0.001);全髋关节及股骨颈BMD与全身各部位脂肪指数无显著相关性(P>0.05)。结论本研究结果表明,绝经后妇女身体局部的脂肪分布与BMD存在相关性,特别对于绝经后超重女性,适当进行功能锻炼、控制脂肪率,可能有利于减少骨量丢失。展开更多
Background:Extrahepatic body fat could be a relevant factor affecting liver regeneration after partial hepatectomy.The aim of this study was to evaluate the potential role of body fatty tissue in liver regeneration ca...Background:Extrahepatic body fat could be a relevant factor affecting liver regeneration after partial hepatectomy.The aim of this study was to evaluate the potential role of body fatty tissue in liver regeneration capacity after liver resection in a cohort of living donors.Methods:We observed liver regeneration in 120 patients:70 living donors who underwent right hepatectomy and 50 recipients who got a right graft transplantation.Liver volumetry and body fat analysis were performed based on the computed tomography images with volumetry software.The gain of liver volume was calculated between three points in time considering the absolute and percentage values:before surgery and early(median 10 days,range 4-21 days)and late(median 27 weeks,range 18-40 weeks)after surgery.Pearson’s correlation was used to examine the potential correlation between adipose tissue and liver regeneration.Results:Pearson’s correlation showed a significant correlation between the subcutaneous fat mass index(sFMI)and early(r=0.173,P=0.030),as well late(r=0.395,P=0.0004)percental liver volume gain in the whole collective.Under stratification in donor’s and recipient’s collectives,the effect of extrahepatic adipose tissue appears in multiple regression only in the donor’s collective:early(β=0.219,T=2.137,P=0.036)and late(β=0.390,T=2.552,P=0.015)percental volume gain.Conclusions:Subcutaneous adipose tissue is a positive predictive factor to estimate the goodness of liver regeneration after partial hepatectomy in normosthenic donors.展开更多
基金We would like to thank Kyung-Do Han from the Catholic University of Korea College of MedicineDepartment of Biostatisticsfor providing statistical support
文摘AIM: To determine whether Helicobacter pylori (H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease (NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectively. Inclusion criteria were age ≥ 20 years, history of H. pylori infection, and recorded insulin level. Participants were classified as H. pylori positive or negative according to <sup>13</sup>C urea breath tests. NAFLD was defined using the hepatic steatosis index (HSI) and NAFLD liver fat score (NAFLD-LFS). Those with an HSI > 36 or NAFLD-LFS > -0.640 were considered to have NAFLD. Multivariable logistic regression was performed to identify risk factors for NAFLD.RESULTS: Three thousand six hundred and sixty-three people were analyzed and 1636 (44.7%) were H. pylori positive. H. pylori infection was associated with older age, male gender, hypertension, higher body mass index, and a dyslipidemic profile. HSI differed significantly between H. pylori positive and negative subjects (median 33.2, interquartile range (IQR) 30.0-36.2 for H. pylori-positive vs median 32.6, IQR 29.8-36.0 for negative participants, P = 0.005), but NAFLD-LSF did not [median -1.7, IQR -2.4 - -0.7 vs median -1.8, IQR -2.4-(-0.7), respectively, P = 0.122]. The percentage of people with NAFLD did not differ between infected and uninfected groups: HIS, 26.9% vs 27.1%, P = 0.173; NAFLD-LFS, 23.5% vs 23.1%, P = 0.778. H. pylori infection was not a risk factor, but C-reactive protein concentration and smoking were significant risk factors for NAFLD.CONCLUSION: H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered.
基金supported by the Netherlands Organization for Scientific Research NWO(Grant No.175.010.2007.006)the Economic Structure Enhancing Fund of the Dutch government+20 种基金the Ministry of Economic Affairsthe Ministry of Education,Culture,and Sciencethe Ministry for Health,Welfare,and Sportsthe Northern Netherlands Alliancethe Province of Groningen,University Medical Center Groningenthe University of Groningen,Dutch Kidney Foundation,and Dutch Diabetes Research Foundationsupported by the Dutch Heart Foundation IN-CONTROL(Grant No.CVON2018-27)the ERC Consolidator Grant(Grant No.101001678)the NWO VICI(Grant No.VI.C.202.022)the Netherlands Organ-on-Chip Initiative,an NWO Gravitation project(Grant No.024.003.001)funded by the Ministry of Education,CultureScience of the government of The Netherlandssupported by the Chinese Scholarship Council.Dasha V.Zhernakova was supported by the NWO VENI(Grant No.194.006)supported by the Seerave Foundation.Rinse K.Weersma and Ranko Gacesa were supported by the TIMID project(Grant No.LSHM18057-SGF)financed by the PPP Allowance made available by Top Sector Life Sciences&Health to Samenwerkende Gezondheidsfondsen(SGF)to stimulate public–private partnerships and co-financing by health foundations that are part of the SGFsupported by the NWO VENI(Grant No.09150161810030)the Health∼Holland Public Private Partnership from the Dutch Ministry of Economic Affairs(Grant No.#PPP-2019-024)supported by the UK Medical Research Council and Wellcome Trustthe UK Department of Healththe Scottish and Welsh Governmentsthe North West Development Agencythe British Heart Foundationthe Diabetes UK.
文摘Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly characterized.Accurate characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk factors.We performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and APOE.GWAS of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between MRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MRI-PDFF genetic signals(CREB3L1 and GCM1)were replicated in the FLI GWAS.We identified two novel genes for MRI-PDFF and 49 replicable loci for FLI.Despite a difference in hepatic fat content assessment between MRI-PDFF and FLI,a substantial similar genetic architecture was found.FLI is identified as an easy and reliable approach to study hepatic fat content at the population level.
文摘Nonalcoholic fatty liver disease(NAFLD)is strongly associated with the metabolic syndrome and type 2 diabetes and independently contributes to long-term complications.Being often asymptomatic but reversible,it would require population-wide screening,but direct diagnostics are either too invasive(liver biopsy),costly(MRI)or depending on the examiner’s expertise(ultrasonography).Hepatosteatosis is usually accommodated by features of the metabolic syndrome(e.g.obesity,disturbances in triglyceride and glucose metabolism),and signs of hepatocellular damage,all of which are reflected by biomarkers,which poorly predict NAFLD as single item,but provide a cheap diagnostic alternative when integrated into composite liver fat indices.Fatty liver index,NAFLD LFS,and hepatic steatosis index are common and accurate indices for NAFLD prediction,but show limited accuracy for liver fat quantification.Other indices are rarely used.Hepatic fibrosis scores are commonly used in clinical practice,but their mandatory reflection of fibrotic reorganization,hepatic injury or systemic sequelae reduces sensitivity for the diagnosis of simple steatosis.Diet-induced liver fat changes are poorly reflected by liver fat indices,depending on the intervention and its specific impact of weight loss on NAFLD.This limited validity in longitudinal settings stimulates research for new equations.Adipokines,hepatokines,markers of cellular integrity,genetic variants but also simple and inexpensive routine parameters might be potential components.Currently,liver fat indices lack precision for NAFLD prediction or monitoring in individual patients,but in large cohorts they may substitute nonexistent imaging data and serve as a compound biomarker of metabolic syndrome and its cardiometabolic sequelae.
文摘该文旨在研究初始脂肪含量、贮存温度对超高温灭菌(ultra high temperature sterilized,UHT)牛奶贮存期间的品质变化及货架期影响规律。对23、30、37℃无光照贮存过程中不同初始脂肪含量UHT纯牛奶的色泽、蛋白水解度、羰基含量进行分析,比较各指标对感官评分的Pearson系数,应用Arrhenius方程等建立货架期预测模型。随着贮存时间的延长、贮存温度的升高,样品的褐变指数、蛋白水解度、羰基含量均随之提高,而感官评分值降低;将感官评分和其他指标进行Pearson相关性分析筛选出褐变指数作为反映其品质变化的关键指标,建立基于初始脂肪含量和贮存温度影响的货架期预测模型,模型预测值与实际货架期验证比较,相对误差小于10%。所建预测模型可有效预测无光照下不同初始脂肪含量UHT牛奶货架期。
文摘目的探讨绝经后女性各部位脂肪指数与骨密度(bone mineral density,BMD)的相关性。方法收集自2019年6月至2020年11月在昆山市中医医院体检中心体检的1229例绝经后妇女的BMD数据(包括L_(1~4)、全髋关节、股骨颈),同时收集身体各部位的脂肪指数数据,按身体质量指数(body mass index,BMI)分为:体重正常组(18.5 kg/m^(2)≤BMI<24 kg/m^(2))和体重超重组(BMI≥24 kg/m^(2))。正常组526例,年龄48~91岁,平均年龄(65.43±9.14)岁。超重组703例,年龄48~86岁,平均年龄(65.33±8.58)岁。通过单因素方差分析以及多元回归分析,探讨绝经后女性各部位脂肪指数与BMD的相关性。结果超重组L_(1~4)BMD、股骨颈BMD及全髋关节BMD均高于体重正常组(P<0.001)。超重组L_(1~4)BMD与全身脂肪指数呈负相关(P<0.001),与Android脂肪指数呈正相关(P<0.001);全髋关节BMD与全身脂肪指数负相关(P=0.006);股骨颈BMD与全身各部位脂肪指数无显著相关性(P>0.05)。体重正常组L_(1~4)BMD与全身脂肪指数呈负相关(P=0.016),与躯干脂肪指数呈正相关(P<0.001);全髋关节及股骨颈BMD与全身各部位脂肪指数无显著相关性(P>0.05)。结论本研究结果表明,绝经后妇女身体局部的脂肪分布与BMD存在相关性,特别对于绝经后超重女性,适当进行功能锻炼、控制脂肪率,可能有利于减少骨量丢失。
文摘Background:Extrahepatic body fat could be a relevant factor affecting liver regeneration after partial hepatectomy.The aim of this study was to evaluate the potential role of body fatty tissue in liver regeneration capacity after liver resection in a cohort of living donors.Methods:We observed liver regeneration in 120 patients:70 living donors who underwent right hepatectomy and 50 recipients who got a right graft transplantation.Liver volumetry and body fat analysis were performed based on the computed tomography images with volumetry software.The gain of liver volume was calculated between three points in time considering the absolute and percentage values:before surgery and early(median 10 days,range 4-21 days)and late(median 27 weeks,range 18-40 weeks)after surgery.Pearson’s correlation was used to examine the potential correlation between adipose tissue and liver regeneration.Results:Pearson’s correlation showed a significant correlation between the subcutaneous fat mass index(sFMI)and early(r=0.173,P=0.030),as well late(r=0.395,P=0.0004)percental liver volume gain in the whole collective.Under stratification in donor’s and recipient’s collectives,the effect of extrahepatic adipose tissue appears in multiple regression only in the donor’s collective:early(β=0.219,T=2.137,P=0.036)and late(β=0.390,T=2.552,P=0.015)percental volume gain.Conclusions:Subcutaneous adipose tissue is a positive predictive factor to estimate the goodness of liver regeneration after partial hepatectomy in normosthenic donors.
