摘要
目的观察蒙药通拉嘎-5对酒精性脂肪肝模型大鼠血清及肝组织中脂质指标的影响。方法 80只Wistar大鼠随机分为空白组和造模组,分别以蒸馏水和高度白酒灌胃8周。造模成功后再随机分为空白组、模型对照组、硫普罗宁组和通拉嘎-5高、中、低剂量组。空白组和模型对照组以羧甲基纤维素钠,硫普罗宁组以硫普罗宁40 mg/kg,通拉嘎-5高、中、低剂量组分别以780 mg/kg、390 mg/kg、195 mg/kg通拉嘎-5灌胃4周后处死,腹主动脉采血,取肝组织,检测血清及肝组织中总胆固醇(TC)和三酰甘油(TG)。结果通拉嘎-5高、中、低剂量组分别与模型对照组比较,血清TC、TG差异均有统计学意义(P<0.01);通拉嘎-5高、中剂量组分别与模型对照组比,肝组织中TC、TG差异均有统计学意义(P<0.01)。结论通拉嘎-5可有效地降低酒精性脂肪肝模型大鼠血清和肝组织中的TC和TG,并且通拉嘎-5中剂量为治疗的首选剂量。
Objective： To observe the effect of Mongolian medicine Tonglaga-5 on the lipid indicators of serum and liver tissue in rats with alcoholic fatty liver. Methods： 80 Wistar rats were randomly divided into blank group and model group,and administrated by distilled water and hard liquor in stomach for 8 weeks. After success of modeiing, they were randomly divided into blank group, model group, Tiopronin group,Tonglaga-5 low, middle and high dose groups respectively. Blank and model groups were given carboxymethyl cellulose natrium while Tio- pronin group were given Tiopronin 40 mg/kg. Tonglaga-5 low,middle and high dosage groups were given 1400 mg/kg,700 mg/kg, 350 mg/kg of Tonglaga-5 respectively. After 4 weeks intragastric administration,they were put to death. Blood samples were collected from abdominal aorta. Liver tissue was taken,and total cholesterol（TC） and triglyceride （TG） in serum and liver tissue were tested. Results： Compared with model group,TC and TG of serum in Tonglaga-5 low,middle and high dose groups had significant differences （P〈 0.01）. Compared with model group,TC and TG of liver tissue in Tonglaga-5 middle and high dose groups had significant differences（P〈 0.01 ）. Conclusion： Tonglaga-5 can effectively reduce TC and TG levels of serum and liver tissue in rat with al- coholic fatty liver,and medium dose is preferred.
出处
《中国中医急症》
2014年第10期1779-1781,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金资助项目(No.81160549)
