目的通过观察用药前后原发性轻中度高血压患者血清细胞凋亡抑制因子Fas/APO-1的水平来评价二氢吡啶钙通道阻滞剂(calc ium channel b lockers,CCB)对细胞凋亡可能的影响。方法采取随机双盲法对照观察原发性轻中度高血压的患者,随机分为...目的通过观察用药前后原发性轻中度高血压患者血清细胞凋亡抑制因子Fas/APO-1的水平来评价二氢吡啶钙通道阻滞剂(calc ium channel b lockers,CCB)对细胞凋亡可能的影响。方法采取随机双盲法对照观察原发性轻中度高血压的患者,随机分为盐酸贝尼地平组和氨氯地平组。治疗前后分别用ELISA的方法检测血清中细胞凋亡抑制因子Fas/APO-1的水平。结果治疗后,两组Fas/APO-1的水平均显著低于治疗前(P=0.001)。两组间治疗前后Fas/APO-1水平的差异无统计学意义(P>0.05)。结论长效二氢吡啶钙通道阻滞剂具有一定抑制细胞凋亡的功能,可改善细胞凋亡与增生之间的失衡。展开更多
The protein expression of bcl-2, bax, Fas/Apo-1 in 19 cases of acute myeloid leukemia (AML) were investigated by Western blot and APAAp techniques. High expression of bcl-2 protein was found in most of the AML cases,a...The protein expression of bcl-2, bax, Fas/Apo-1 in 19 cases of acute myeloid leukemia (AML) were investigated by Western blot and APAAp techniques. High expression of bcl-2 protein was found in most of the AML cases,and some of the cases expressed Fas/Apo-1 and bax. High expression of bcl-2 protein was associated with a bad clinical prognosis and a poor response after intensive chemotherapy. Bax seemed to coexpress with bcl-2 and so appeared to be a bad prognostic factor instead of a good one. The expression of Fas/Apo-1 was inversely correlated with hcf-2 and seemed to be a good prognostic factor which may reflect the relative homeostasis of apoptotic pathway. It is concluded that apoptosis-induced pathways in AML often exhibit disturbance features. Coregulation of bcl-2, Bax and Fas/Apo-1 genes formed the apoptosis-induced pathway,which is the biological factor affecting response to chemotherapy.展开更多
文摘目的通过观察用药前后原发性轻中度高血压患者血清细胞凋亡抑制因子Fas/APO-1的水平来评价二氢吡啶钙通道阻滞剂(calc ium channel b lockers,CCB)对细胞凋亡可能的影响。方法采取随机双盲法对照观察原发性轻中度高血压的患者,随机分为盐酸贝尼地平组和氨氯地平组。治疗前后分别用ELISA的方法检测血清中细胞凋亡抑制因子Fas/APO-1的水平。结果治疗后,两组Fas/APO-1的水平均显著低于治疗前(P=0.001)。两组间治疗前后Fas/APO-1水平的差异无统计学意义(P>0.05)。结论长效二氢吡啶钙通道阻滞剂具有一定抑制细胞凋亡的功能,可改善细胞凋亡与增生之间的失衡。
文摘The protein expression of bcl-2, bax, Fas/Apo-1 in 19 cases of acute myeloid leukemia (AML) were investigated by Western blot and APAAp techniques. High expression of bcl-2 protein was found in most of the AML cases,and some of the cases expressed Fas/Apo-1 and bax. High expression of bcl-2 protein was associated with a bad clinical prognosis and a poor response after intensive chemotherapy. Bax seemed to coexpress with bcl-2 and so appeared to be a bad prognostic factor instead of a good one. The expression of Fas/Apo-1 was inversely correlated with hcf-2 and seemed to be a good prognostic factor which may reflect the relative homeostasis of apoptotic pathway. It is concluded that apoptosis-induced pathways in AML often exhibit disturbance features. Coregulation of bcl-2, Bax and Fas/Apo-1 genes formed the apoptosis-induced pathway,which is the biological factor affecting response to chemotherapy.
