I.How it started I entered the Rega Institute for Medical Research in August 1964,as a medical student,to start working under the guidance of Prof.Piet De Somer,then professor of microbiology at the Leuven School of M...I.How it started I entered the Rega Institute for Medical Research in August 1964,as a medical student,to start working under the guidance of Prof.Piet De Somer,then professor of microbiology at the Leuven School of Medicine.When I graduated展开更多
In this review article,a number of milestones in the antiviral research field on nucleosides and nucleotides are reviewed in which the author played a significant part,especially in the initial stages of their develop...In this review article,a number of milestones in the antiviral research field on nucleosides and nucleotides are reviewed in which the author played a significant part,especially in the initial stages of their development.Highlighted are the amino acyl esters of acyclovir,particularly valacyclovir(VACV),brivudin(BVDU)and the valine ester of Cf1743(FV-100),the.2′,3′-dideoxynucleosides(nucleoside reverse transcri ptase inhibitors,NRTIs),the acyclic nucleoside phosphonates(S)-HPMPA,(S)-HPMPC(cidofovir)and alkoxyalkyl esters thereof(HDP-,ODE-CDV),adefovir and adefovir dipivoxil,tenofovir and tenofovir disoproxil fumarate(TDF),combinations containing TDF and emtricitabine,i.e.,Truvada■,Atripla■,Complera■/Eviplera■ and the Quad pill,and the phosphonoamidate derivatives GS-7340,GS-9131,GS-9191 and GS-9219.展开更多
文摘I.How it started I entered the Rega Institute for Medical Research in August 1964,as a medical student,to start working under the guidance of Prof.Piet De Somer,then professor of microbiology at the Leuven School of Medicine.When I graduated
文摘In this review article,a number of milestones in the antiviral research field on nucleosides and nucleotides are reviewed in which the author played a significant part,especially in the initial stages of their development.Highlighted are the amino acyl esters of acyclovir,particularly valacyclovir(VACV),brivudin(BVDU)and the valine ester of Cf1743(FV-100),the.2′,3′-dideoxynucleosides(nucleoside reverse transcri ptase inhibitors,NRTIs),the acyclic nucleoside phosphonates(S)-HPMPA,(S)-HPMPC(cidofovir)and alkoxyalkyl esters thereof(HDP-,ODE-CDV),adefovir and adefovir dipivoxil,tenofovir and tenofovir disoproxil fumarate(TDF),combinations containing TDF and emtricitabine,i.e.,Truvada■,Atripla■,Complera■/Eviplera■ and the Quad pill,and the phosphonoamidate derivatives GS-7340,GS-9131,GS-9191 and GS-9219.
