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Milestones in the discovery of antiviral agents:nucleosides and nucleotides

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摘要 In this review article,a number of milestones in the antiviral research field on nucleosides and nucleotides are reviewed in which the author played a significant part,especially in the initial stages of their development.Highlighted are the amino acyl esters of acyclovir,particularly valacyclovir(VACV),brivudin(BVDU)and the valine ester of Cf1743(FV-100),the.2′,3′-dideoxynucleosides(nucleoside reverse transcri ptase inhibitors,NRTIs),the acyclic nucleoside phosphonates(S)-HPMPA,(S)-HPMPC(cidofovir)and alkoxyalkyl esters thereof(HDP-,ODE-CDV),adefovir and adefovir dipivoxil,tenofovir and tenofovir disoproxil fumarate(TDF),combinations containing TDF and emtricitabine,i.e.,Truvada■,Atripla■,Complera■/Eviplera■ and the Quad pill,and the phosphonoamidate derivatives GS-7340,GS-9131,GS-9191 and GS-9219.
出处 《Acta Pharmaceutica Sinica B》 SCIE CAS 2012年第6期535-548,共14页 药学学报(英文版)
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