The purpose of this study was to explore the different effects between biomimetic mineralized collagen(MC)and ordinary physically blended hydroxyapatite/collagen(HA/Col)composite in evaluating new bone formation and r...The purpose of this study was to explore the different effects between biomimetic mineralized collagen(MC)and ordinary physically blended hydroxyapatite/collagen(HA/Col)composite in evaluating new bone formation and regenerated bone height in human extraction sockets.Thirty-four patients who cannot retain teeth caused by trauma or decay were randomly selected from Department of Stomatology of Dongzhimen Hospital from December 2013 to December 2014.The patients were randomly divided into two groups.After the operation of tooth extraction,17 patients were implanted with biomimetic MC(MC group),and other 17 patients were implanted with ordinary physically blended nHA/Col composite(nHA/Col group).X-ray positioning projection by auto-photographing was taken to test the distance between the lowest position and the neighboring CEJm-CEJd immediately,1 month and 3 months after the operation.The height of new bone formation of the MC group was significantly higher than the nHA/Col group.Biomimetic MC showed better clinical outcomes in the bone formation for extraction site preservation and would have broad application prospect in the field of oral and maxillofacial surgeries.展开更多
目的:研究骨诱导活性材料(Osteoinduction Active Material,OAM)复合富血小板纤维蛋白(Platelet-rich Fibrin,PRF)在拔牙位点引导新骨形成的作用,考察OAM复合PRF促进拔牙位点保存修复的效果。方法:选取12月龄健康雄性Beagle犬6只,建立...目的:研究骨诱导活性材料(Osteoinduction Active Material,OAM)复合富血小板纤维蛋白(Platelet-rich Fibrin,PRF)在拔牙位点引导新骨形成的作用,考察OAM复合PRF促进拔牙位点保存修复的效果。方法:选取12月龄健康雄性Beagle犬6只,建立动物模型,微创拔除两侧上、下颌第二侧切牙。4个位点随机分为A、B、C、D 4组,分别植入PRF与OAM复合物、单一的PRF或OAM,以及空白对照。术后1个月和3个月,分别处死3只动物并立即在拔牙位点部位取材,制作组织切片H.E和甲苯胺蓝染色,进行骨计量学分析。结果:A组骨小梁宽度、位点区骨量和成骨细胞数均明显大于其他3组(P<0.01)。析因分析显示OAM复合PRF在拔牙位点区引导新骨形成的效果优于单独使用OAM或PRF(P<0.01)。结论:OAM复合PRF可以增加拔牙位点区的成骨细胞数。骨量明显增加,有助于骨改建和改善拔牙位点区牙槽骨质量。展开更多
Problems associated with organochlorine pesticide （OCP）-contaminated sites in China have received wide attention. To solve such problems, innovative ex-situ methods of site remediation are urgently needed. We invest...Problems associated with organochlorine pesticide （OCP）-contaminated sites in China have received wide attention. To solve such problems, innovative ex-situ methods of site remediation are urgently needed. We investigated the feasibility of the extraction method with different organic solvents, ethanol, 1-propanol, and three fractions of petroleum ether, using a soil collected from Wujiang （W J）, China, a region with long-term contamination of dichlorodiphenyltrichloroethanes （DDTs）. We evaluated different influential factors, including organic solvent concentration, washing time, mixing speed, solutiomto-soil ratio, and washing temperature, on the removal of DDTs from the WJ soil. A set of relatively better parameters were selected for extraction with 100 mL L-1 petroleum ether （60-90 ℃）： washing time of 180 min, mixing speed of 100 r min-I, solution-to-soil ratio of 10：1, and washing temperature of 50 ℃. These selected parameters were also applied on three other seriously OCP-polluted soils. Results demonstrated their broad-spectrum effectiveness and excellent OCP extraction performance on the contaminated soils with different characteristics.展开更多
基金supported by the National Basic Research Program of China(973 Program,2011CB606205)the‘Twelfth Five-Year’National Science and Technology Support Program(2012BAI17B02)the Ministry of Science and Technology of China and the National Natural Science Foundation of China(Grant Nos.21371106 and 51402167).
文摘The purpose of this study was to explore the different effects between biomimetic mineralized collagen(MC)and ordinary physically blended hydroxyapatite/collagen(HA/Col)composite in evaluating new bone formation and regenerated bone height in human extraction sockets.Thirty-four patients who cannot retain teeth caused by trauma or decay were randomly selected from Department of Stomatology of Dongzhimen Hospital from December 2013 to December 2014.The patients were randomly divided into two groups.After the operation of tooth extraction,17 patients were implanted with biomimetic MC(MC group),and other 17 patients were implanted with ordinary physically blended nHA/Col composite(nHA/Col group).X-ray positioning projection by auto-photographing was taken to test the distance between the lowest position and the neighboring CEJm-CEJd immediately,1 month and 3 months after the operation.The height of new bone formation of the MC group was significantly higher than the nHA/Col group.Biomimetic MC showed better clinical outcomes in the bone formation for extraction site preservation and would have broad application prospect in the field of oral and maxillofacial surgeries.
文摘目的:研究骨诱导活性材料(Osteoinduction Active Material,OAM)复合富血小板纤维蛋白(Platelet-rich Fibrin,PRF)在拔牙位点引导新骨形成的作用,考察OAM复合PRF促进拔牙位点保存修复的效果。方法:选取12月龄健康雄性Beagle犬6只,建立动物模型,微创拔除两侧上、下颌第二侧切牙。4个位点随机分为A、B、C、D 4组,分别植入PRF与OAM复合物、单一的PRF或OAM,以及空白对照。术后1个月和3个月,分别处死3只动物并立即在拔牙位点部位取材,制作组织切片H.E和甲苯胺蓝染色,进行骨计量学分析。结果:A组骨小梁宽度、位点区骨量和成骨细胞数均明显大于其他3组(P<0.01)。析因分析显示OAM复合PRF在拔牙位点区引导新骨形成的效果优于单独使用OAM或PRF(P<0.01)。结论:OAM复合PRF可以增加拔牙位点区的成骨细胞数。骨量明显增加,有助于骨改建和改善拔牙位点区牙槽骨质量。
基金Supported by the National High Technology Research and Development Program of China (No. 2009AA063103)the National Natural Science Foundation of China (No. 41030531)
文摘Problems associated with organochlorine pesticide （OCP）-contaminated sites in China have received wide attention. To solve such problems, innovative ex-situ methods of site remediation are urgently needed. We investigated the feasibility of the extraction method with different organic solvents, ethanol, 1-propanol, and three fractions of petroleum ether, using a soil collected from Wujiang （W J）, China, a region with long-term contamination of dichlorodiphenyltrichloroethanes （DDTs）. We evaluated different influential factors, including organic solvent concentration, washing time, mixing speed, solutiomto-soil ratio, and washing temperature, on the removal of DDTs from the WJ soil. A set of relatively better parameters were selected for extraction with 100 mL L-1 petroleum ether （60-90 ℃）： washing time of 180 min, mixing speed of 100 r min-I, solution-to-soil ratio of 10：1, and washing temperature of 50 ℃. These selected parameters were also applied on three other seriously OCP-polluted soils. Results demonstrated their broad-spectrum effectiveness and excellent OCP extraction performance on the contaminated soils with different characteristics.
