An environmental force termed KELEA (kinetic energy limiting electrostatic attraction) is postulated to reduce the strength of intermolecular (hydrogen) bonding of water molecules, resulting in increased kinetic activ...An environmental force termed KELEA (kinetic energy limiting electrostatic attraction) is postulated to reduce the strength of intermolecular (hydrogen) bonding of water molecules, resulting in increased kinetic activity of the water. While regular water does not directly absorb KELEA from the environment, various dipolar compounds with separated electrical charges can seemingly act as a primary antenna for KELEA, with secondary transfer of energy into nearby water. Moreover, once sufficiently activated, the separated electrical charges in activated water can apparently function as a receiver for KELEA, leading to further activation of the water and also to the activation of added water. Prior publications have addressed the agricultural and potential clinical benefits of using KELEA activated water. This article is intended as the first in a series of papers describing useful industrial applications of KELEA activated water. The focus of the present paper is on the improved efficiency of industrial water heating and cooling systems by using KELEA activated water provided by pelleted, ground and heated volcanic rock as supplied by Kiko Technology.展开更多
In the present study,we employed electrostatic spray technology to fabricate mesoporous microspheres containing sodium hyaluronate(SHMM).This approach aimed to overcome a significant challenge in the formulation devel...In the present study,we employed electrostatic spray technology to fabricate mesoporous microspheres containing sodium hyaluronate(SHMM).This approach aimed to overcome a significant challenge in the formulation development process,specifically addressing the limited water-locking ability inherent to the double-helix structure of sodium hyaluronate(SH).Various parameters were systematically investigated,including the solvent employed,concentrations of SH and poly(ethylene oxide),electrospray flow rate,voltage settings,and needle diameter.Through systematic single-factor testing,we identified the optimal formulation process for generating SH microspheres characterized by favorable morphology and particle size.Additionally,a similar single-factor examination focused on the concentration of the pore-forming agent and the drying temperature,leading to the successful production of mesoporous microspheres with discernible pores.The porosity of the three distinct batches of mesoporous microspheres was consistently measured at 20.30%±1.51%.Moreover,all these microspheres displayed a negative surface potential when suspended in water,affirming their strong capacity to bind with positively charged protein drugs.These findings underscored the feasibility of drug loading through ion exchange in subsequent stages.Notably,the successful preparation of recombinant human interferonα-2b crosslinked mesoporous microspheres(rhIFNα-2b-SHCMM)was achieved,demonstrating both high entrapment efficiency and an enhanced drug loading capacity.展开更多
文摘An environmental force termed KELEA (kinetic energy limiting electrostatic attraction) is postulated to reduce the strength of intermolecular (hydrogen) bonding of water molecules, resulting in increased kinetic activity of the water. While regular water does not directly absorb KELEA from the environment, various dipolar compounds with separated electrical charges can seemingly act as a primary antenna for KELEA, with secondary transfer of energy into nearby water. Moreover, once sufficiently activated, the separated electrical charges in activated water can apparently function as a receiver for KELEA, leading to further activation of the water and also to the activation of added water. Prior publications have addressed the agricultural and potential clinical benefits of using KELEA activated water. This article is intended as the first in a series of papers describing useful industrial applications of KELEA activated water. The focus of the present paper is on the improved efficiency of industrial water heating and cooling systems by using KELEA activated water provided by pelleted, ground and heated volcanic rock as supplied by Kiko Technology.
基金The 2023 Nantong Social Livelihood Science and Technology Plan2023 Nantong Jianghai Talents Project+3 种基金2022 New Drugs and Platform Enhancement Project of the Yangtze Delta Drug Advanced Research Institute. Zhenjiang Science and Technology Pro ject (Grant No. SH2020048)China Postdoctoral Science Foundation (Gr ant No. 2020M681532)Jiangsu Planned Projects for Postdoctoral Research Funds (Grant No. 2020Z209)Natural Science Research Pro jects of Universities in Jiangsu Province (Grant No. 20KJD350001)。
文摘In the present study,we employed electrostatic spray technology to fabricate mesoporous microspheres containing sodium hyaluronate(SHMM).This approach aimed to overcome a significant challenge in the formulation development process,specifically addressing the limited water-locking ability inherent to the double-helix structure of sodium hyaluronate(SH).Various parameters were systematically investigated,including the solvent employed,concentrations of SH and poly(ethylene oxide),electrospray flow rate,voltage settings,and needle diameter.Through systematic single-factor testing,we identified the optimal formulation process for generating SH microspheres characterized by favorable morphology and particle size.Additionally,a similar single-factor examination focused on the concentration of the pore-forming agent and the drying temperature,leading to the successful production of mesoporous microspheres with discernible pores.The porosity of the three distinct batches of mesoporous microspheres was consistently measured at 20.30%±1.51%.Moreover,all these microspheres displayed a negative surface potential when suspended in water,affirming their strong capacity to bind with positively charged protein drugs.These findings underscored the feasibility of drug loading through ion exchange in subsequent stages.Notably,the successful preparation of recombinant human interferonα-2b crosslinked mesoporous microspheres(rhIFNα-2b-SHCMM)was achieved,demonstrating both high entrapment efficiency and an enhanced drug loading capacity.
