目的比较米非司酮联合米索前列醇与羊膜腔外注射依沙丫啶用于妊娠中期引产的效果。方法选择因死胎、胎儿畸形等特殊原因妊娠中期(14~26周)要求终止妊娠妇女88例,按照用药方式分为A组和B组各44例。A组口服米非司酮联合阴道内置米索前列...目的比较米非司酮联合米索前列醇与羊膜腔外注射依沙丫啶用于妊娠中期引产的效果。方法选择因死胎、胎儿畸形等特殊原因妊娠中期(14~26周)要求终止妊娠妇女88例,按照用药方式分为A组和B组各44例。A组口服米非司酮联合阴道内置米索前列醇,B组羊膜腔外注射依沙丫啶,对比两组的引产情况、用药后VAS评分、宫颈Bishop评分。结果 A组的引产成功率为100.00%,与B组的95.45%比较差异无统计学意义(P>0.05)。A组的清宫率为4.55%显著低于B组的18.18%,宫缩启动时间、胎盘娩出时间及产后出血量均显著低于B组,差异均有统计学意义(P<0.05)。用药后6、12、24 h A组的VAS评分均显著低于B组,Bishop评分显著高于B组,差异均有统计学意义(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论米非司酮联合米索前列醇用于妊娠中期引产的效果优于羊膜腔注射依沙丫啶,能够减轻疼痛并改善宫颈软化情况。展开更多
Severe liver dysfunction in pregnancy(SLDP) is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ...Severe liver dysfunction in pregnancy(SLDP) is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy in patients with SLD. A total of 55 patients with indications of labor induction were enrolled and analyzed by retrospective control analysis method. Twenty-three cases adopted Cook double balloon dilation as Cook group, and 32 cases received intra-amniotic injection of ethacridine lactate as EL group. The primary outcome was evaluated by successful abortion rate and the difference in the induction-to-abortion interval. Secondary outcomes included liver function recovery and the frequency of adverse events. Both Cook and EL regimens were effective, with successful abortion rate of 87.0% and 93.8%, respectively(P=0.639). The induction-to-delivery interval was similar between Cook group and EL group(38.1±21.5 vs. 41.3±17.4, P=0.543). The liver disease status was more severe in Cook group than in EL group, but it did not show any significant difference after pregnancy termination between the two groups and the improvement rate also did not show any significant difference. Both treatments were safe and there was no significant difference in bleeding and cervical laceration adverse events between the two groups. Our study firstly compared double-balloon catheter and ethacridine lactate for the induction of labor in women with SLD during second trimester pregnancy.展开更多
文摘目的比较米非司酮联合米索前列醇与羊膜腔外注射依沙丫啶用于妊娠中期引产的效果。方法选择因死胎、胎儿畸形等特殊原因妊娠中期(14~26周)要求终止妊娠妇女88例,按照用药方式分为A组和B组各44例。A组口服米非司酮联合阴道内置米索前列醇,B组羊膜腔外注射依沙丫啶,对比两组的引产情况、用药后VAS评分、宫颈Bishop评分。结果 A组的引产成功率为100.00%,与B组的95.45%比较差异无统计学意义(P>0.05)。A组的清宫率为4.55%显著低于B组的18.18%,宫缩启动时间、胎盘娩出时间及产后出血量均显著低于B组,差异均有统计学意义(P<0.05)。用药后6、12、24 h A组的VAS评分均显著低于B组,Bishop评分显著高于B组,差异均有统计学意义(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论米非司酮联合米索前列醇用于妊娠中期引产的效果优于羊膜腔注射依沙丫啶,能够减轻疼痛并改善宫颈软化情况。
基金supported by a grant from the National Natural Science Foundation of China(No.81372806)
文摘Severe liver dysfunction in pregnancy(SLDP) is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy in patients with SLD. A total of 55 patients with indications of labor induction were enrolled and analyzed by retrospective control analysis method. Twenty-three cases adopted Cook double balloon dilation as Cook group, and 32 cases received intra-amniotic injection of ethacridine lactate as EL group. The primary outcome was evaluated by successful abortion rate and the difference in the induction-to-abortion interval. Secondary outcomes included liver function recovery and the frequency of adverse events. Both Cook and EL regimens were effective, with successful abortion rate of 87.0% and 93.8%, respectively(P=0.639). The induction-to-delivery interval was similar between Cook group and EL group(38.1±21.5 vs. 41.3±17.4, P=0.543). The liver disease status was more severe in Cook group than in EL group, but it did not show any significant difference after pregnancy termination between the two groups and the improvement rate also did not show any significant difference. Both treatments were safe and there was no significant difference in bleeding and cervical laceration adverse events between the two groups. Our study firstly compared double-balloon catheter and ethacridine lactate for the induction of labor in women with SLD during second trimester pregnancy.