Background Endogenous hydrogen sulfide （H2S） plays an important role in hypertension. The aim of this study was to investigate the role of erythrocyte and serum H2S in patients with untreated essential hypertension....Background Endogenous hydrogen sulfide （H2S） plays an important role in hypertension. The aim of this study was to investigate the role of erythrocyte and serum H2S in patients with untreated essential hypertension. Methods We recruited 62 patients （age 22-74 years） with untreated prehypertension or hypertension, and 64 normotensive subjects （age 18-64 years）. We assessed the 3-mercaptopyruvate sulphurtransferase （MPST） protein expression in erythrocytes and measured the H2S production from erythrocytes and serum H2S levels, then analyzed the association of erythrocytic or serum H2S content and blood pressure or cardiovascular risk factors （e.g., age, body mass index （BMI） and dyslipidemia）. A stepwise regression analysis was used to evaluate the possible relationship of erythrocytic H2S in hypertension. Results In hypertensive patients, erythrocyte H2S production （（111.04_＋.29.20） nmol/min per 10a erythrocytes） was higher than that in controls （（78.85＋19.38） nmol/min per 108 erythrocytes）, and serum H2S was also higher. The erythrocytic H2S production was associated with increased systolic blood pressure （sBP）, diastolic blood pressure （dBP）, age, BMI, level of C-reactive protein （CRP）, as well as triglycerides （TG） and high density lipoprotein cholesterol （HDL-C） Serum H2S was not associated with age or CRP. Stepwise regression analysis showed that erythrocytic H2S production was correlated with sBP, TG, HDL-C, low density lipoprotein cholesterol （LDL-C） and blood urea nitrogen （BUN） and serum H2S was correlated with dBP and TG. Results of receiver-operating characteristic curve analysis suggested that erythrocytic H2S production was a more sensitive predictor of hypertension development than serum H2S. Conclusion Ervthrocvtic or serum H^S Production is sensitive predictor of hvDertension.展开更多
The purpose of this paper is to study the changes of deformabilityof erythrocytes and 2.3-DPG(2.3-diphosphoglycerate acid)in the patients with coro-nary artery stenosis and the effects of some factors on them.It is sh...The purpose of this paper is to study the changes of deformabilityof erythrocytes and 2.3-DPG(2.3-diphosphoglycerate acid)in the patients with coro-nary artery stenosis and the effects of some factors on them.It is showed that:de-formability of crythrocyte and 2.3-DPG were inversely proportional to the degreeof the lesions of coronary vessels(P【0.01);there was a significant decrease of de-formability of erythrocytes after using contract agents(P【0.01);Salvia increaseddeformability and 2.3-DPG significantly(P【0.01).In conclusion,our data suggestthat the possible existence of microcirculation dysfunction in coronary artery dis-eases with parallelism to the impairement deformability of erythrocytcs and Salviabca good drug to action in deformability and 2.3 DPG in patients.展开更多
A new model of rats with Xueyu Syndrome which was characterized by erythrocyte injury was presented. Observation of morphology and functions of erythrocytes showed that this model could not only be used as a model i...A new model of rats with Xueyu Syndrome which was characterized by erythrocyte injury was presented. Observation of morphology and functions of erythrocytes showed that this model could not only be used as a model in Xueyu Syndrome and Huoxuequyu treatment study, but also be used for screening of drugs with the effect of preventing and treating damage of red blood cells.展开更多
基金This work was supported by grants from the Major State Basic Research Development Program of China （No. 2006CB503807） and the National Natural Science Foundation of China （No. 30971084, 30821001）.
文摘Background Endogenous hydrogen sulfide （H2S） plays an important role in hypertension. The aim of this study was to investigate the role of erythrocyte and serum H2S in patients with untreated essential hypertension. Methods We recruited 62 patients （age 22-74 years） with untreated prehypertension or hypertension, and 64 normotensive subjects （age 18-64 years）. We assessed the 3-mercaptopyruvate sulphurtransferase （MPST） protein expression in erythrocytes and measured the H2S production from erythrocytes and serum H2S levels, then analyzed the association of erythrocytic or serum H2S content and blood pressure or cardiovascular risk factors （e.g., age, body mass index （BMI） and dyslipidemia）. A stepwise regression analysis was used to evaluate the possible relationship of erythrocytic H2S in hypertension. Results In hypertensive patients, erythrocyte H2S production （（111.04_＋.29.20） nmol/min per 10a erythrocytes） was higher than that in controls （（78.85＋19.38） nmol/min per 108 erythrocytes）, and serum H2S was also higher. The erythrocytic H2S production was associated with increased systolic blood pressure （sBP）, diastolic blood pressure （dBP）, age, BMI, level of C-reactive protein （CRP）, as well as triglycerides （TG） and high density lipoprotein cholesterol （HDL-C） Serum H2S was not associated with age or CRP. Stepwise regression analysis showed that erythrocytic H2S production was correlated with sBP, TG, HDL-C, low density lipoprotein cholesterol （LDL-C） and blood urea nitrogen （BUN） and serum H2S was correlated with dBP and TG. Results of receiver-operating characteristic curve analysis suggested that erythrocytic H2S production was a more sensitive predictor of hypertension development than serum H2S. Conclusion Ervthrocvtic or serum H^S Production is sensitive predictor of hvDertension.
文摘The purpose of this paper is to study the changes of deformabilityof erythrocytes and 2.3-DPG(2.3-diphosphoglycerate acid)in the patients with coro-nary artery stenosis and the effects of some factors on them.It is showed that:de-formability of crythrocyte and 2.3-DPG were inversely proportional to the degreeof the lesions of coronary vessels(P【0.01);there was a significant decrease of de-formability of erythrocytes after using contract agents(P【0.01);Salvia increaseddeformability and 2.3-DPG significantly(P【0.01).In conclusion,our data suggestthat the possible existence of microcirculation dysfunction in coronary artery dis-eases with parallelism to the impairement deformability of erythrocytcs and Salviabca good drug to action in deformability and 2.3 DPG in patients.
基金This project was supported by the National Natural ScienceFoundation of China (No. 39270826).
文摘A new model of rats with Xueyu Syndrome which was characterized by erythrocyte injury was presented. Observation of morphology and functions of erythrocytes showed that this model could not only be used as a model in Xueyu Syndrome and Huoxuequyu treatment study, but also be used for screening of drugs with the effect of preventing and treating damage of red blood cells.
