Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors.It is well recognized that long noncoding RNAs(lncRNAs)regulate ene...Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors.It is well recognized that long noncoding RNAs(lncRNAs)regulate energy metabolism in cancer.However,lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present.In this review,we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes,transcription factors,and other proteins involved in metabolic pathways.In addition,we discuss the mechanisms through which these interactions contribute to tumor initiation and progression,and the key roles and clinical significance of functional lncRNAs.We believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.展开更多
Three proteases were applied to treatments of wool. The shrinkage, dyeing behavior, some physical and mechanical properties of treated wool were studied. Peroxymonosulfate(PMS)and lipase were used to pretreat wool bef...Three proteases were applied to treatments of wool. The shrinkage, dyeing behavior, some physical and mechanical properties of treated wool were studied. Peroxymonosulfate(PMS)and lipase were used to pretreat wool before the treatment of it by protease. The results show that the shrink resistance of wool fabric is not obtained when it is treated only by the protease, but it is remarkably improved when the wool fabric is treated first by PMS or a lipase afterwards by protease The rate of dyeing is increased when the wool is treated by protease or combination of oxidant/lipase and protease. Whiteness, luster and softness of treated wool are improved, while the strength and elasticity are reduced.展开更多
基金This study was supported by the National Key R&D Program of China(2018YFC1313304 and 2018YFC1313300)the National Natural Science Foundation of China(82073112,82022052 and 81871951).
文摘Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors.It is well recognized that long noncoding RNAs(lncRNAs)regulate energy metabolism in cancer.However,lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present.In this review,we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes,transcription factors,and other proteins involved in metabolic pathways.In addition,we discuss the mechanisms through which these interactions contribute to tumor initiation and progression,and the key roles and clinical significance of functional lncRNAs.We believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.
文摘Three proteases were applied to treatments of wool. The shrinkage, dyeing behavior, some physical and mechanical properties of treated wool were studied. Peroxymonosulfate(PMS)and lipase were used to pretreat wool before the treatment of it by protease. The results show that the shrink resistance of wool fabric is not obtained when it is treated only by the protease, but it is remarkably improved when the wool fabric is treated first by PMS or a lipase afterwards by protease The rate of dyeing is increased when the wool is treated by protease or combination of oxidant/lipase and protease. Whiteness, luster and softness of treated wool are improved, while the strength and elasticity are reduced.
