In the present study,17 flavonoids,including 9 prenylated isoflavones,4 isoflavones,3 flavanones and 1 flavone,were isolated from the twigs and leaves of Erythrina variegata.By NMR spectroscopic means and comparision ...In the present study,17 flavonoids,including 9 prenylated isoflavones,4 isoflavones,3 flavanones and 1 flavone,were isolated from the twigs and leaves of Erythrina variegata.By NMR spectroscopic means and comparision with the data in the leteratures,their structures were elucidated to be euchrenone b10(1),senegalensin(2),erythrinin C(3),scandenone(4),osajin(5),alpinum isoflavone(6),isoerysenegalensein E(7),erysenegalensein E(8),diprenylgenistein(9),abyssinone V(10),abyssinone V 4′-methyl ether(11),4′,7-dihydroxyflavanone(12),3′,5,7-trihydroxy-4′-methoxyisoflavone(13),2′,4′,5,7-tetrahydroxyisoflavone(14),genistein(15),daidzein(16),and apigenin(17).Except for compounds 1,4-7,and 9-10,other compounds were isolated from E.variegata for the first time.展开更多
A total of 15 compounds were extracted from the ethyl acetate extraction of the twigs and leaves of Erythrina strica.Based on NMR spectral data, their structures were identified as loliolide(1), phaseic acid(2), pinna...A total of 15 compounds were extracted from the ethyl acetate extraction of the twigs and leaves of Erythrina strica.Based on NMR spectral data, their structures were identified as loliolide(1), phaseic acid(2), pinnatififidanoid A(3), soyasapogenol E(4), soyasapogenol B(5), 2α,3α,19α,23-tetrahydroxyurs-12-en-28-oic acid(6), 3β,22β,24-trihydroxyolean-12-en-29-oic acid(oxytrogenin)(7),(23 Z)-9,19-cycloart-23-ene-3β,25-diol(8), 3,4-dihydroxybenzoic acid(9), syringaresinol(10),(E)-4-hydroxy-dodec-2-enedioic acid(11), lutein(12), ergosterol-5,8-peroxide(13), β-sitosterol(14), and daucosterol(15). Except for compounds 13–15,all the compounds were isolated from this plant for the first time. Moreover, sesquiterpenoids were isolated from Erythrina genus for the first time.展开更多
Erythrinarbine 2, a novel alkaloid was isolated from the stem of Erythrina arborescens Roxb. Its structure and stereochemistry were elucidated on the basis of the spectral analysis (C-13 - H-1 COSY, H-1-H-1 COSY, NOES...Erythrinarbine 2, a novel alkaloid was isolated from the stem of Erythrina arborescens Roxb. Its structure and stereochemistry were elucidated on the basis of the spectral analysis (C-13 - H-1 COSY, H-1-H-1 COSY, NOESY and HMBC).展开更多
Erythrina senegalensis is utilized in the treatment of liver diseases in folklore medicine in most of northern Nigeria, but sufficient pharmacological-based and peer-reviewed scientific literature is not available to ...Erythrina senegalensis is utilized in the treatment of liver diseases in folklore medicine in most of northern Nigeria, but sufficient pharmacological-based and peer-reviewed scientific literature is not available to authenticate its use in the treatment of liver ailments. This research is aimed at assessing the hepatoprotective effects of Erythrina senegalensis against paracetamol-induced (PCM-induced) hepatotoxicity in wistar albino rats. This was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) as compared with the control group. The extract was concentrated and then desired concentrations of extracts were made by dissolving in normal saline. Four different doses of aqueous extracts Erythrina senegalensis (200, 300, 400 and 500 mg/kg) were administered orally for 6 consecutive days after the 72 hrs administration of paracetamol (1500 mg/kg) per body weight. Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Administration of the extracts showed significant (p 0.05) and dose-dependent hepatoprotective activity resulting in decrease in the activity of ALT, AST and ALP. These data revealed that Erythrina senegalensis aqueous extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.展开更多
Fourteen unprecedented artificial Erythrina alkaloids were isolated from the Erythrina variegata,E.crista-galli and E.arborescens(Fabaceae).The structures of these alkaloids were determined by spectroscopic analyses.T...Fourteen unprecedented artificial Erythrina alkaloids were isolated from the Erythrina variegata,E.crista-galli and E.arborescens(Fabaceae).The structures of these alkaloids were determined by spectroscopic analyses.Their possible forma-tions were proposed.All isolated compounds showed no cytotoxicity and hypoglycemic activity at cell screening bioassay.展开更多
Objective:To study the behavioral effects of semi purified fraction prepared from the stem bark of Erythrina velutina on mice.Methods:Three chloroformic fractions(CA) at 50 or 100 mg/kg(CA1,CA2 and CA3) were tested in...Objective:To study the behavioral effects of semi purified fraction prepared from the stem bark of Erythrina velutina on mice.Methods:Three chloroformic fractions(CA) at 50 or 100 mg/kg(CA1,CA2 and CA3) were tested in two behavioral tests;plus maze and open field.Results:In the plus maze test,it was observed a decrease in the number of entries in the closed arms(NECA) CA2 at both doses as compared to the control group.In the open field test,CA2 and CA3 fractions decreased the number of squares crossed and the time of permanence on the bar,increased the number of falls at both doses in the rota rod test.The CA2 fraction decreased the NECA,but this data did not characterize an anxiolytic effect.It was the consequence from decrease of locomotor activity(LA) observed in the open field test,that the decrease of LA and rearing,the number of falls and the decrease in time of permanence on the bar in rota rod test were observed after treatment with CA2 and CA3 at both doses,suggesting sedative effect.Conclusion:The present work demonstrated that CA2 and CA3 fractions have impairing effect on LA and motor coordination.展开更多
Background:Erythrina suberosa(E.suberosa)Roxb.also known as corky coral tree is used as a folklore medicine to treat ulcers and piles.This study explored the phytochemical profiles of methanol and dichloromethane(DCM)...Background:Erythrina suberosa(E.suberosa)Roxb.also known as corky coral tree is used as a folklore medicine to treat ulcers and piles.This study explored the phytochemical profiles of methanol and dichloromethane(DCM)extracts from the aerial,root,and flower parts of E.suberosa.Method:Total bioactive contents,high-performance liquid chromatography array(HPLC-PDA)polyphenolic quantification,and ultra-high performance liquid chromatography-mass spectrometry(UHPLC-MS)analysis were used to evaluate the phytochemical profile.Biological potential was evaluated by determining their antioxidant(DPPH,ABTS,FRAP,CUPRAC,Phosphomolybdenum,and metal chelating)and enzyme inhibitory(cholinesterase,amylase,glucosidase,and tyrosinase)effects.Results:The phenolic(46.26 mg GAE/g extract)and flavonoid(32.46 mg QE/g extract)contents were found to be highest in the methanolic extract of roots(EsR-M).HPLC-PDA analysis determined the presence of numerous bioactive compounds,including catechin,syringic acid,p-hydroxy benzoic acid,gallic acid,vanillic acid,epicatechin,rutin,chlorogenic acid,carvacrol,sinapinic acid,and naringenin in considerable amounts.A total of 143 phytochemicals,belonging to phenolic,flavonoid,coumarin,terpenoid,chalcone,saponin,and glycoside classes,were tentatively identified by UHPLC-MS analysis.Aerial methanolic extract(EsA-M)exhibited highest radical scavenging(DPPH 86.81 mgTE/g extract,ABTS 245.17 mgTE/g extract)as well as reducing potential(FRAP 177.12 mgTE/g extract,CUPRAC 177.12 mgTE/g extract).Likewise,it was also noted to be most active for BChE(5.70 mg GALAE/g extract)and tyrosinase inhibition(148.35 mg KAE/g extract).While,roots-DCM extract(EsR-D)presented considerable inhibition for AChE(4.69 mg GALAE/g extract)and amylase(0.81 mmol ACAE/g extract)enzymes.Coreopsin,davallioside A,and isovitexin were docked to tyrosinase to depict possible interaction.Conclusion:This study has established baseline data on the biological and phytochemical profile of E.suberosa which was found to possess antioxidant and enzym展开更多
Five hitherto unknown isoflavonoids,namely erythrinins D-H(1-5),were isolated from the ethanol extract of Erythrina arborescens.Their structures were elucidated on the basis of extensive spectroscopic studies.In addit...Five hitherto unknown isoflavonoids,namely erythrinins D-H(1-5),were isolated from the ethanol extract of Erythrina arborescens.Their structures were elucidated on the basis of extensive spectroscopic studies.In addition,the structure of anagyroidisoflavone A(6a)has been revised as 1″-O-methylerythrinin F(6)by re-analysis of the original spectroscopic data.展开更多
Although the classical Ritter reaction has beenwidely applied to prepare sterically hindered amides since 1948,it has intrinsic problems,such as harsh reaction conditions,the multistep preparation of synthetic precurs...Although the classical Ritter reaction has beenwidely applied to prepare sterically hindered amides since 1948,it has intrinsic problems,such as harsh reaction conditions,the multistep preparation of synthetic precursors,and the use of solvent quantities of nitrile.In particular,only a few examples of the total synthesis of natural products using the Ritter reaction as a key step have been reported to date.展开更多
A concise synthetic route leading to highly functional erythrina alkaloid skeletons has been developed.The key process is an oxidative carbon-carbon coupling followed by a conjugated addition.Based on this new strateg...A concise synthetic route leading to highly functional erythrina alkaloid skeletons has been developed.The key process is an oxidative carbon-carbon coupling followed by a conjugated addition.Based on this new strategy,a formal synthesis of demethoxyerythratidinone was completed in only 6 steps from 4-aminophenol.展开更多
基金National Natural Science Foundation of China(Grant No.32060099).
文摘In the present study,17 flavonoids,including 9 prenylated isoflavones,4 isoflavones,3 flavanones and 1 flavone,were isolated from the twigs and leaves of Erythrina variegata.By NMR spectroscopic means and comparision with the data in the leteratures,their structures were elucidated to be euchrenone b10(1),senegalensin(2),erythrinin C(3),scandenone(4),osajin(5),alpinum isoflavone(6),isoerysenegalensein E(7),erysenegalensein E(8),diprenylgenistein(9),abyssinone V(10),abyssinone V 4′-methyl ether(11),4′,7-dihydroxyflavanone(12),3′,5,7-trihydroxy-4′-methoxyisoflavone(13),2′,4′,5,7-tetrahydroxyisoflavone(14),genistein(15),daidzein(16),and apigenin(17).Except for compounds 1,4-7,and 9-10,other compounds were isolated from E.variegata for the first time.
基金National Natural Science Foundation of China (Grant No. 32060099)。
文摘A total of 15 compounds were extracted from the ethyl acetate extraction of the twigs and leaves of Erythrina strica.Based on NMR spectral data, their structures were identified as loliolide(1), phaseic acid(2), pinnatififidanoid A(3), soyasapogenol E(4), soyasapogenol B(5), 2α,3α,19α,23-tetrahydroxyurs-12-en-28-oic acid(6), 3β,22β,24-trihydroxyolean-12-en-29-oic acid(oxytrogenin)(7),(23 Z)-9,19-cycloart-23-ene-3β,25-diol(8), 3,4-dihydroxybenzoic acid(9), syringaresinol(10),(E)-4-hydroxy-dodec-2-enedioic acid(11), lutein(12), ergosterol-5,8-peroxide(13), β-sitosterol(14), and daucosterol(15). Except for compounds 13–15,all the compounds were isolated from this plant for the first time. Moreover, sesquiterpenoids were isolated from Erythrina genus for the first time.
文摘Erythrinarbine 2, a novel alkaloid was isolated from the stem of Erythrina arborescens Roxb. Its structure and stereochemistry were elucidated on the basis of the spectral analysis (C-13 - H-1 COSY, H-1-H-1 COSY, NOESY and HMBC).
文摘Erythrina senegalensis is utilized in the treatment of liver diseases in folklore medicine in most of northern Nigeria, but sufficient pharmacological-based and peer-reviewed scientific literature is not available to authenticate its use in the treatment of liver ailments. This research is aimed at assessing the hepatoprotective effects of Erythrina senegalensis against paracetamol-induced (PCM-induced) hepatotoxicity in wistar albino rats. This was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) as compared with the control group. The extract was concentrated and then desired concentrations of extracts were made by dissolving in normal saline. Four different doses of aqueous extracts Erythrina senegalensis (200, 300, 400 and 500 mg/kg) were administered orally for 6 consecutive days after the 72 hrs administration of paracetamol (1500 mg/kg) per body weight. Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Administration of the extracts showed significant (p 0.05) and dose-dependent hepatoprotective activity resulting in decrease in the activity of ALT, AST and ALP. These data revealed that Erythrina senegalensis aqueous extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.
基金supported in part by the National Natural Science Foundation of China(31872677).
文摘Fourteen unprecedented artificial Erythrina alkaloids were isolated from the Erythrina variegata,E.crista-galli and E.arborescens(Fabaceae).The structures of these alkaloids were determined by spectroscopic analyses.Their possible forma-tions were proposed.All isolated compounds showed no cytotoxicity and hypoglycemic activity at cell screening bioassay.
文摘Objective:To study the behavioral effects of semi purified fraction prepared from the stem bark of Erythrina velutina on mice.Methods:Three chloroformic fractions(CA) at 50 or 100 mg/kg(CA1,CA2 and CA3) were tested in two behavioral tests;plus maze and open field.Results:In the plus maze test,it was observed a decrease in the number of entries in the closed arms(NECA) CA2 at both doses as compared to the control group.In the open field test,CA2 and CA3 fractions decreased the number of squares crossed and the time of permanence on the bar,increased the number of falls at both doses in the rota rod test.The CA2 fraction decreased the NECA,but this data did not characterize an anxiolytic effect.It was the consequence from decrease of locomotor activity(LA) observed in the open field test,that the decrease of LA and rearing,the number of falls and the decrease in time of permanence on the bar in rota rod test were observed after treatment with CA2 and CA3 at both doses,suggesting sedative effect.Conclusion:The present work demonstrated that CA2 and CA3 fractions have impairing effect on LA and motor coordination.
文摘Background:Erythrina suberosa(E.suberosa)Roxb.also known as corky coral tree is used as a folklore medicine to treat ulcers and piles.This study explored the phytochemical profiles of methanol and dichloromethane(DCM)extracts from the aerial,root,and flower parts of E.suberosa.Method:Total bioactive contents,high-performance liquid chromatography array(HPLC-PDA)polyphenolic quantification,and ultra-high performance liquid chromatography-mass spectrometry(UHPLC-MS)analysis were used to evaluate the phytochemical profile.Biological potential was evaluated by determining their antioxidant(DPPH,ABTS,FRAP,CUPRAC,Phosphomolybdenum,and metal chelating)and enzyme inhibitory(cholinesterase,amylase,glucosidase,and tyrosinase)effects.Results:The phenolic(46.26 mg GAE/g extract)and flavonoid(32.46 mg QE/g extract)contents were found to be highest in the methanolic extract of roots(EsR-M).HPLC-PDA analysis determined the presence of numerous bioactive compounds,including catechin,syringic acid,p-hydroxy benzoic acid,gallic acid,vanillic acid,epicatechin,rutin,chlorogenic acid,carvacrol,sinapinic acid,and naringenin in considerable amounts.A total of 143 phytochemicals,belonging to phenolic,flavonoid,coumarin,terpenoid,chalcone,saponin,and glycoside classes,were tentatively identified by UHPLC-MS analysis.Aerial methanolic extract(EsA-M)exhibited highest radical scavenging(DPPH 86.81 mgTE/g extract,ABTS 245.17 mgTE/g extract)as well as reducing potential(FRAP 177.12 mgTE/g extract,CUPRAC 177.12 mgTE/g extract).Likewise,it was also noted to be most active for BChE(5.70 mg GALAE/g extract)and tyrosinase inhibition(148.35 mg KAE/g extract).While,roots-DCM extract(EsR-D)presented considerable inhibition for AChE(4.69 mg GALAE/g extract)and amylase(0.81 mmol ACAE/g extract)enzymes.Coreopsin,davallioside A,and isovitexin were docked to tyrosinase to depict possible interaction.Conclusion:This study has established baseline data on the biological and phytochemical profile of E.suberosa which was found to possess antioxidant and enzym
基金This work was financially supported by the"Large-scale Compound Library"project of the National Development and Reform Commission of China,the National Basic Research Program of China(973 Program)2009CB522300the"Western Light"talents training program of Chinese Academy of Sciences.
文摘Five hitherto unknown isoflavonoids,namely erythrinins D-H(1-5),were isolated from the ethanol extract of Erythrina arborescens.Their structures were elucidated on the basis of extensive spectroscopic studies.In addition,the structure of anagyroidisoflavone A(6a)has been revised as 1″-O-methylerythrinin F(6)by re-analysis of the original spectroscopic data.
基金the NSFC(grant nos.21971095,21772076,and 91956203.)for financially supporting this work.
文摘Although the classical Ritter reaction has beenwidely applied to prepare sterically hindered amides since 1948,it has intrinsic problems,such as harsh reaction conditions,the multistep preparation of synthetic precursors,and the use of solvent quantities of nitrile.In particular,only a few examples of the total synthesis of natural products using the Ritter reaction as a key step have been reported to date.
基金This work was supported by grants(20925205,21062026,2010GA014 and 2009CB522300) from National Natural Science Foundation of China,Yunnan Province and National Basic Research Program of China(973 Program).
文摘A concise synthetic route leading to highly functional erythrina alkaloid skeletons has been developed.The key process is an oxidative carbon-carbon coupling followed by a conjugated addition.Based on this new strategy,a formal synthesis of demethoxyerythratidinone was completed in only 6 steps from 4-aminophenol.
