Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive im...Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.展开更多
目的观察复方阿胶浆对化疗所致小细胞肺癌患者骨髓抑制的影响。方法将确诊的135例小细胞肺癌患者分为对照组(n=70)和治疗组(n=65),对照组给予EP方案常规化疗,治疗组在EP方案常规化疗同时口服复方阿胶浆,3次/d,20 m L/次;观察两组患者化...目的观察复方阿胶浆对化疗所致小细胞肺癌患者骨髓抑制的影响。方法将确诊的135例小细胞肺癌患者分为对照组(n=70)和治疗组(n=65),对照组给予EP方案常规化疗,治疗组在EP方案常规化疗同时口服复方阿胶浆,3次/d,20 m L/次;观察两组患者化疗完成情况及化疗后的血红蛋白(Hb)、血小板(PLT)、白细胞(WBC)和中性粒细胞(NEUT)变化等骨髓抑制情况。结果治疗组的化疗完成率高于对照组;治疗组的WBC、NEUT下降幅度明显低于对照组(P<0.05)。结论复方阿胶浆可降低WBC及NEUT骨髓抑制发生率,并改善化疗所致小细胞肺癌患者的WBC及NEUT减少情况。展开更多
基金supported by the National Key R&D Program of China(2018YFC1707300)the Taishan Industrial Experts Program(tscx202211148).
文摘Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.
文摘目的观察复方阿胶浆对化疗所致小细胞肺癌患者骨髓抑制的影响。方法将确诊的135例小细胞肺癌患者分为对照组(n=70)和治疗组(n=65),对照组给予EP方案常规化疗,治疗组在EP方案常规化疗同时口服复方阿胶浆,3次/d,20 m L/次;观察两组患者化疗完成情况及化疗后的血红蛋白(Hb)、血小板(PLT)、白细胞(WBC)和中性粒细胞(NEUT)变化等骨髓抑制情况。结果治疗组的化疗完成率高于对照组;治疗组的WBC、NEUT下降幅度明显低于对照组(P<0.05)。结论复方阿胶浆可降低WBC及NEUT骨髓抑制发生率,并改善化疗所致小细胞肺癌患者的WBC及NEUT减少情况。
