目的探讨甲状腺功能亢进患者糖代谢的变化及甲状腺功能亢进对胰岛素敏感性的影响。方法收集2012年1月—2014年12月收治的甲状腺功能亢进患者68例,根据口服葡萄糖耐量试验(OGTT),将患者分为葡萄糖耐量受损组(IGT组,n=32例),糖耐量正常组(...目的探讨甲状腺功能亢进患者糖代谢的变化及甲状腺功能亢进对胰岛素敏感性的影响。方法收集2012年1月—2014年12月收治的甲状腺功能亢进患者68例,根据口服葡萄糖耐量试验(OGTT),将患者分为葡萄糖耐量受损组(IGT组,n=32例),糖耐量正常组(NGT组,n=36例),并与健康体检者(NC组,n=30例)比较,检测各组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)、促甲状腺激素(TSH),并计算胰岛素抵抗指数(HOMA-IR)和胰岛索敏感指数(HOMA-IS)。结果 IGT组FPG及OGTT各时间点糖负荷均明显高于NGT组、NC组(F=63.65、95.84、71.36、137.48,P<0.05),NGT组OGTT 2h、3h糖负荷显著高于NC组(P<0.05),而FPG、OGTT 1h糖负荷与NC组间均无显著性差异(P>0.05);IGT组HOMA-IR明显高于NGT组、NC组,HOMA-IS则明显降低(F=52.32、13.71,P<0.05)。与治疗前比较,治疗后甲状腺功能亢进患者FT、FT_4、FPG、2 h PG及HOMA-IR均明显降低,TSH、HOMA-IS明显升高(P<0.05)。Pearson相关分析结果表明,HOMAIR与TSH呈负相关(r=-0.568,P<0.05)、与2 hPG呈正相关(r=0.625,P<0.05),HOMA-IS与TSH呈正相关(r=0.554,P<0.05)、与2 h PG呈负相关(r=-0.487,P<0.05)。结论甲状腺功能亢进患者常伴有糖代谢紊乱,胰岛素敏感性降低,在积极治疗甲状腺功能亢进的同时,需加强血糖监测,预防并发症的发生。展开更多
Methyl tert-butyl ether (MTBE),as a widely used gasoline additive,is suspected of being environmentally toxic.MTBE accumulates mainly in adipose tissue,but its effect on obesity or obesity-related metabolic disorders ...Methyl tert-butyl ether (MTBE),as a widely used gasoline additive,is suspected of being environmentally toxic.MTBE accumulates mainly in adipose tissue,but its effect on obesity or obesity-related metabolic disorders has not been well understood yet.Therefore,we examined the effect of MTBE on the adipose function and the related metabolic processes with both 3T3-L1 cell line and C57BL/6J mice model.We found that exposure to MTBE at the environmental relevant concentration (100 μmol/L) could significantly induce differentiation of preadipocyte and disturb insulin-stimulated glucose uptake of mature adipocyte.The in vivo observation in male mice showed a positive correlation of visceral white adipose tissue (vWAT) expansion and cell size increase with MTBE treatment in 14 weeks.Glucose tolerance and insulin sensitivity tests demonstrated that MTBE at 1000 μg/(kg·day) disturbed the systemic glucose metabolism in a gender-specific manner,which might be partly attributed to the alterations of gut microbiota community at genus level with respect to Akkermansia,Clostridium XIVb,and Megamonas.In summary,our study characterized the effect of MTBE on adipose tissue function and glucose homeostasis in vitro and in vivo,and revealed that systemic disorders of the glucose metabolism might be modulated by the related gut microbiota.展开更多
文摘目的探讨甲状腺功能亢进患者糖代谢的变化及甲状腺功能亢进对胰岛素敏感性的影响。方法收集2012年1月—2014年12月收治的甲状腺功能亢进患者68例,根据口服葡萄糖耐量试验(OGTT),将患者分为葡萄糖耐量受损组(IGT组,n=32例),糖耐量正常组(NGT组,n=36例),并与健康体检者(NC组,n=30例)比较,检测各组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)、促甲状腺激素(TSH),并计算胰岛素抵抗指数(HOMA-IR)和胰岛索敏感指数(HOMA-IS)。结果 IGT组FPG及OGTT各时间点糖负荷均明显高于NGT组、NC组(F=63.65、95.84、71.36、137.48,P<0.05),NGT组OGTT 2h、3h糖负荷显著高于NC组(P<0.05),而FPG、OGTT 1h糖负荷与NC组间均无显著性差异(P>0.05);IGT组HOMA-IR明显高于NGT组、NC组,HOMA-IS则明显降低(F=52.32、13.71,P<0.05)。与治疗前比较,治疗后甲状腺功能亢进患者FT、FT_4、FPG、2 h PG及HOMA-IR均明显降低,TSH、HOMA-IS明显升高(P<0.05)。Pearson相关分析结果表明,HOMAIR与TSH呈负相关(r=-0.568,P<0.05)、与2 hPG呈正相关(r=0.625,P<0.05),HOMA-IS与TSH呈正相关(r=0.554,P<0.05)、与2 h PG呈负相关(r=-0.487,P<0.05)。结论甲状腺功能亢进患者常伴有糖代谢紊乱,胰岛素敏感性降低,在积极治疗甲状腺功能亢进的同时,需加强血糖监测,预防并发症的发生。
基金supported by the Strategic Priority Research Program of CAS(No.XDB14040201)National Natural Science Foundation of China(Nos.21806179,21621064 and21672255)
文摘Methyl tert-butyl ether (MTBE),as a widely used gasoline additive,is suspected of being environmentally toxic.MTBE accumulates mainly in adipose tissue,but its effect on obesity or obesity-related metabolic disorders has not been well understood yet.Therefore,we examined the effect of MTBE on the adipose function and the related metabolic processes with both 3T3-L1 cell line and C57BL/6J mice model.We found that exposure to MTBE at the environmental relevant concentration (100 μmol/L) could significantly induce differentiation of preadipocyte and disturb insulin-stimulated glucose uptake of mature adipocyte.The in vivo observation in male mice showed a positive correlation of visceral white adipose tissue (vWAT) expansion and cell size increase with MTBE treatment in 14 weeks.Glucose tolerance and insulin sensitivity tests demonstrated that MTBE at 1000 μg/(kg·day) disturbed the systemic glucose metabolism in a gender-specific manner,which might be partly attributed to the alterations of gut microbiota community at genus level with respect to Akkermansia,Clostridium XIVb,and Megamonas.In summary,our study characterized the effect of MTBE on adipose tissue function and glucose homeostasis in vitro and in vivo,and revealed that systemic disorders of the glucose metabolism might be modulated by the related gut microbiota.
