【目的】探讨定颤解郁方(由经方天麻钩藤饮合柴胡龙骨牡蛎汤化裁而来)对帕金森抑郁(depression in Parkinson’s disease,DPD)患者的临床疗效和安全性。【方法】将80例DPD肝郁风动扰神证患者随机分为单纯西药治疗组(简称西药组)和定颤...【目的】探讨定颤解郁方(由经方天麻钩藤饮合柴胡龙骨牡蛎汤化裁而来)对帕金森抑郁(depression in Parkinson’s disease,DPD)患者的临床疗效和安全性。【方法】将80例DPD肝郁风动扰神证患者随机分为单纯西药治疗组(简称西药组)和定颤解郁方联合西药治疗组(简称联合组),每组各40例。西药组给予美多芭联合盐酸普拉克索片的西医常规治疗,联合组在西药组的基础上联合定颤解郁方治疗,连续服用14 d为1个疗程,共治疗6个疗程(共12周)。观察2组患者治疗前后主要结局指标24项汉密尔顿抑郁量表(HAMD-24)评分以及次要结局指标世界运动障碍学会新版帕金森病综合评价量表(MDSUPDRS)、帕金森病睡眠障碍量表(PDSS)和汉密尔顿焦虑量表(HAMA)评分的变化情况,并评价2组患者的临床疗效(根据HAMD-24评分的改善情况判定)和安全性。【结果】(1)疗效方面,治疗12周后,联合组的总有效率为70.0%(28/40),西药组为27.5%(11/40),组间比较,联合组的疗效明显优于西药组(P<0.01)。(2)HAMD-24、HAMA、PDSS评分方面,治疗后,2组患者的HAMD-24、HAMA、PDSS评分均较治疗前明显下降(P<0.05),且联合组的下降幅度均明显优于西药组(P<0.05)。(3)MDS-UPDRS评分方面,治疗后,2组患者MDS-UPDRS的日常生活非运动症状评分及联合组的日常生活运动症状评分均较治疗前明显下降(P<0.05),而2组患者的运动检查和运动并发症评分及西药组的日常生活运动症状评分均较治疗前无明显下降(P>0.05);组间比较,联合组对日常生活非运动症状评分的下降幅度明显优于对照组(P<0.05)。(4)不良事件发生率方面,治疗过程中,2组患者的所有不良事件都是轻微的,其中联合组的不良事件发生率为12.5%(5/40),西药组为10.0%(4/40),组间比较,差异无统计学意义(P>0.05)。【结论】在西医常规治疗基础上联合定颤解郁方治疗DPD肝郁风动扰神证患者临床疗效确切,可有效改�展开更多
This study showed that abnormal behavioral changes were greatly improved in rats displaying Parkinson＇s disease-like symptoms after intragastric administration of Xifeng Dingchan decoction at 15, 7.5, 3.75 g/kg per d...This study showed that abnormal behavioral changes were greatly improved in rats displaying Parkinson＇s disease-like symptoms after intragastric administration of Xifeng Dingchan decoction at 15, 7.5, 3.75 g/kg per day. In addition, tyrosine hydroxylase mRNA expression in the substantia nigra of the midbrain was up-regulated, and tyrosine hydroxylase content in the midbrain ventral tegmentum and substantia nigra pars compacta was also increased. The effect of administration of Xifeng Dingchan decoction at 7.5 g/kg per day was similar to that of Madopar at 67.5 mg/kg per day. These results indicate that the therapeutic effect of Xifeng Dingchan decoction on Parkinson＇s disease is associated with the up-regulated protein and mRNA expression of tyrosine hydroxylase in the midbrain.展开更多
文摘【目的】探讨定颤解郁方(由经方天麻钩藤饮合柴胡龙骨牡蛎汤化裁而来)对帕金森抑郁(depression in Parkinson’s disease,DPD)患者的临床疗效和安全性。【方法】将80例DPD肝郁风动扰神证患者随机分为单纯西药治疗组(简称西药组)和定颤解郁方联合西药治疗组(简称联合组),每组各40例。西药组给予美多芭联合盐酸普拉克索片的西医常规治疗,联合组在西药组的基础上联合定颤解郁方治疗,连续服用14 d为1个疗程,共治疗6个疗程(共12周)。观察2组患者治疗前后主要结局指标24项汉密尔顿抑郁量表(HAMD-24)评分以及次要结局指标世界运动障碍学会新版帕金森病综合评价量表(MDSUPDRS)、帕金森病睡眠障碍量表(PDSS)和汉密尔顿焦虑量表(HAMA)评分的变化情况,并评价2组患者的临床疗效(根据HAMD-24评分的改善情况判定)和安全性。【结果】(1)疗效方面,治疗12周后,联合组的总有效率为70.0%(28/40),西药组为27.5%(11/40),组间比较,联合组的疗效明显优于西药组(P<0.01)。(2)HAMD-24、HAMA、PDSS评分方面,治疗后,2组患者的HAMD-24、HAMA、PDSS评分均较治疗前明显下降(P<0.05),且联合组的下降幅度均明显优于西药组(P<0.05)。(3)MDS-UPDRS评分方面,治疗后,2组患者MDS-UPDRS的日常生活非运动症状评分及联合组的日常生活运动症状评分均较治疗前明显下降(P<0.05),而2组患者的运动检查和运动并发症评分及西药组的日常生活运动症状评分均较治疗前无明显下降(P>0.05);组间比较,联合组对日常生活非运动症状评分的下降幅度明显优于对照组(P<0.05)。(4)不良事件发生率方面,治疗过程中,2组患者的所有不良事件都是轻微的,其中联合组的不良事件发生率为12.5%(5/40),西药组为10.0%(4/40),组间比较,差异无统计学意义(P>0.05)。【结论】在西医常规治疗基础上联合定颤解郁方治疗DPD肝郁风动扰神证患者临床疗效确切,可有效改�
基金Projects of Heilongjiang Province Administration of Traditional Chinese Medicine,No.ZH04Z74Second-Class Award of Scientific Advancement of Heilongjiang Province Administration of Traditional Chinese Medicine in 2007
文摘This study showed that abnormal behavioral changes were greatly improved in rats displaying Parkinson＇s disease-like symptoms after intragastric administration of Xifeng Dingchan decoction at 15, 7.5, 3.75 g/kg per day. In addition, tyrosine hydroxylase mRNA expression in the substantia nigra of the midbrain was up-regulated, and tyrosine hydroxylase content in the midbrain ventral tegmentum and substantia nigra pars compacta was also increased. The effect of administration of Xifeng Dingchan decoction at 7.5 g/kg per day was similar to that of Madopar at 67.5 mg/kg per day. These results indicate that the therapeutic effect of Xifeng Dingchan decoction on Parkinson＇s disease is associated with the up-regulated protein and mRNA expression of tyrosine hydroxylase in the midbrain.
