Background: Oral aphthosis has a negative impact on oral health. This study aimed to assess the effectiveness of gel formulation including diclofenac and propolis in the treatment of oral ulcers. Methods: Participants...Background: Oral aphthosis has a negative impact on oral health. This study aimed to assess the effectiveness of gel formulation including diclofenac and propolis in the treatment of oral ulcers. Methods: Participants included 100 normal individuals with aphthous, excluding those having allergies to any ingredient in the diclofenac formulation. Patients were randomly assigned into two groups: one group received treatment with a combination of diclofenac potassium 3% (10 mg/g, 60 g) and propolis 5% gel (Group II), and the other group received a placebo (Group 1). The patient was evaluated using standard digital photographs and chronic oral mucosal questionnaires on days 1, 3, 5, and 7 after healing. Utilizing the Mann-Whitney U test, the two groups were compared. Each group’s changes were examined using Friedman’s test. Results: There was a statistically dramatic change over time in Group II. After one day, the median total score dropped statistically significantly, and from one to three days with effect size (d) 2.485, Group II demonstrated 48% complete healing and 52% partial healing, while Group I demonstrated 4% partial healing and 96% no change. Effect size (V): 0.995. Conclusions: The combination of diclofenac and propolis provided instant relief and an affordable new regimen for treating oral aphthosis.展开更多
目的优化双氯芬酸钾口腔黏附片处方。方法采用32满因子设计试验考察因素A(卡波姆和羟丙甲基纤维素的总量在处方中所占的比例)和因素B(卡波姆与羟丙甲基纤维素的质量比)对黏附时间和体外30、180、480 m in的累积释放度的影响,试验数据分...目的优化双氯芬酸钾口腔黏附片处方。方法采用32满因子设计试验考察因素A(卡波姆和羟丙甲基纤维素的总量在处方中所占的比例)和因素B(卡波姆与羟丙甲基纤维素的质量比)对黏附时间和体外30、180、480 m in的累积释放度的影响,试验数据分别采用线性方程和二次多项式拟合,根据最佳数学模型绘制效应面和等高线图,通过重叠等高线图确定最优处方。结果2个影响因素和4个评价指标之间存在定量关系,最优处方:卡波姆和羟丙甲基纤维素的总量在处方中占30%,卡波姆与羟丙甲基纤维素的质量比为0.75∶1。优化处方各指标的预测值和目标值较接近。结论采用因子设计-重叠等高线图法完成了双氯芬酸钾口腔黏附片的多目标同步优化。展开更多
文摘Background: Oral aphthosis has a negative impact on oral health. This study aimed to assess the effectiveness of gel formulation including diclofenac and propolis in the treatment of oral ulcers. Methods: Participants included 100 normal individuals with aphthous, excluding those having allergies to any ingredient in the diclofenac formulation. Patients were randomly assigned into two groups: one group received treatment with a combination of diclofenac potassium 3% (10 mg/g, 60 g) and propolis 5% gel (Group II), and the other group received a placebo (Group 1). The patient was evaluated using standard digital photographs and chronic oral mucosal questionnaires on days 1, 3, 5, and 7 after healing. Utilizing the Mann-Whitney U test, the two groups were compared. Each group’s changes were examined using Friedman’s test. Results: There was a statistically dramatic change over time in Group II. After one day, the median total score dropped statistically significantly, and from one to three days with effect size (d) 2.485, Group II demonstrated 48% complete healing and 52% partial healing, while Group I demonstrated 4% partial healing and 96% no change. Effect size (V): 0.995. Conclusions: The combination of diclofenac and propolis provided instant relief and an affordable new regimen for treating oral aphthosis.
文摘目的优化双氯芬酸钾口腔黏附片处方。方法采用32满因子设计试验考察因素A(卡波姆和羟丙甲基纤维素的总量在处方中所占的比例)和因素B(卡波姆与羟丙甲基纤维素的质量比)对黏附时间和体外30、180、480 m in的累积释放度的影响,试验数据分别采用线性方程和二次多项式拟合,根据最佳数学模型绘制效应面和等高线图,通过重叠等高线图确定最优处方。结果2个影响因素和4个评价指标之间存在定量关系,最优处方:卡波姆和羟丙甲基纤维素的总量在处方中占30%,卡波姆与羟丙甲基纤维素的质量比为0.75∶1。优化处方各指标的预测值和目标值较接近。结论采用因子设计-重叠等高线图法完成了双氯芬酸钾口腔黏附片的多目标同步优化。
