摘要
目的 研究双氯芬酸钾 (DP)脂质体制剂的制备及体外的经皮吸收特点。方法 采用改良均质法制备DP钾脂质体制剂 ;采用改良Franz扩散池 ,研究DP脂质体制剂与上市凝胶制剂大鼠皮肤的体外透皮吸收差异。结果 改良均质法制备的DP脂质体 ,平均粒径为 3 45nm ,粒径分布比较均匀 ,包封率为 87 3 %。体外透皮实验中 ,DP脂质体制剂较凝胶制剂的透皮能力高 (P <0 0 5 )。结论 脂质体包封的双氯芬酸钾制剂质地均一 ,稳定 。
Objective To study the preparation of topical liposomal diclofenac potassium (DP) formulation and the percutaneous absorption in vitro . Methods DP was encapsuled in liposome. The difference of in vitro percutaneous absorption of DP formulation and commercial gel formulation in modified Franz diffusion device was observed. Results The diameter of liposomal DP formulation was around 345 nm. The liposomal DP formulation could penetrate through the rat skin more effectively in vitro , as compared with that of the commercial gel formulation. The rate of percutaneous penetration of liposomal DP formulation was higher than that of commercial gel formulation ( P <0 05). Conclusion The liposomal DP formulation can penetrate through the skin more effectively than the commercial gel formulation.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第6期509-512,共4页
Journal of Third Military Medical University
基金
中关村科技生物医药创新研究基金资助项目 ( 2 0 0 0 2 )~~
关键词
脂质体
双氯芬酸钾
体外
皮肤渗透
liposome
diclofenac potassium
in vitro
percutaneous penetration
