目的探讨雷公藤多苷联合异维A酸胶囊治疗囊肿型痤疮患者疗效及对血清炎症因子、胰岛素样生长因子1（insulin like growth factor 1,IGF-1）和脱氢表雄酮（dehydroepiandrosterone,DHEA）的影响。方法选取囊肿型痤疮患者118例按照随机数...目的探讨雷公藤多苷联合异维A酸胶囊治疗囊肿型痤疮患者疗效及对血清炎症因子、胰岛素样生长因子1（insulin like growth factor 1,IGF-1）和脱氢表雄酮（dehydroepiandrosterone,DHEA）的影响。方法选取囊肿型痤疮患者118例按照随机数字表法分为观察组与对照组。对照组患者采用异维A酸胶囊治疗,观察组在对照组基础上结合雷公藤多苷片治疗。2组疗程均为8周。结果观察组患者治疗总有效率（89.83%）高于对照组（71.19%）（P〈0.05）;观察组患者治疗后囊肿数目少于对照组（P〈0.05）;观察组患者治疗后血清IL-2和IL-4水平下降且低于对照组（P〈0.05）;观察组患者治疗后血清IGF-1和DHEA水平下降且低于对照组（P〈0.05）;观察组复发率（11.86%）低于对照组（30.51%）（P〈0.05）;2组不良反应发生率比较无统计学意义。结论雷公藤多苷片联合异维A酸胶囊治疗囊肿型痤疮患者疗效明显,且可降低血清炎症因子IL-2和IL-4水平及降低IGF-1和DHEA水平,复发率低,不良反应少。展开更多
Populations living at high altitudes （HAs）, particularly in the Peruvian Andes, are characterized by a mixture of subjects with erythrocytosis （16 g dl-1〈haemoglobin （Hb）≤21 gdl-1） and others with excessive er...Populations living at high altitudes （HAs）, particularly in the Peruvian Andes, are characterized by a mixture of subjects with erythrocytosis （16 g dl-1〈haemoglobin （Hb）≤21 gdl-1） and others with excessive erythrocytosis （EE） （Hb〉21 g dl-1）. Elevated haemoglobin values （EE） are associated with chronic mountain sickness, a condition reflecting the lack of adaptation to HA. According to current data, native men from regions of HA are not adequately adapted to live at such altitudes if they have elevated serum testosterone levels. This seems to be due to an increased conversion of dehydroepiandrosterone sulphate （DH EAS） to testosterone. Men with erythrocytosis at HAs show higher serum androstenedione levels and a lower testosterone/androstenedione ratio than men with EE, suggesting reduced 17beta-hydroxysteroid dehydrogenase （17beta-HSD） activity. Lower 17beta-HSD activity via A4-steroid production in men with erythrocytosis at HA may protect against elevated serum testosterone levels, thus preventing EE. The higher conversion of DHEAS to testosterone in subjects with EE indicates increased 17beta-HSD activity via the A5-pathway. Currently, there are various situations in which people live （human biodiversity） with low or high haemoglobin levels at HA. Antiquity could be an important adaptation component for life at HA, and testosterone seems to participate in this process.展开更多
文摘目的探讨雷公藤多苷联合异维A酸胶囊治疗囊肿型痤疮患者疗效及对血清炎症因子、胰岛素样生长因子1（insulin like growth factor 1,IGF-1）和脱氢表雄酮（dehydroepiandrosterone,DHEA）的影响。方法选取囊肿型痤疮患者118例按照随机数字表法分为观察组与对照组。对照组患者采用异维A酸胶囊治疗,观察组在对照组基础上结合雷公藤多苷片治疗。2组疗程均为8周。结果观察组患者治疗总有效率（89.83%）高于对照组（71.19%）（P〈0.05）;观察组患者治疗后囊肿数目少于对照组（P〈0.05）;观察组患者治疗后血清IL-2和IL-4水平下降且低于对照组（P〈0.05）;观察组患者治疗后血清IGF-1和DHEA水平下降且低于对照组（P〈0.05）;观察组复发率（11.86%）低于对照组（30.51%）（P〈0.05）;2组不良反应发生率比较无统计学意义。结论雷公藤多苷片联合异维A酸胶囊治疗囊肿型痤疮患者疗效明显,且可降低血清炎症因子IL-2和IL-4水平及降低IGF-1和DHEA水平,复发率低,不良反应少。
文摘Populations living at high altitudes （HAs）, particularly in the Peruvian Andes, are characterized by a mixture of subjects with erythrocytosis （16 g dl-1〈haemoglobin （Hb）≤21 gdl-1） and others with excessive erythrocytosis （EE） （Hb〉21 g dl-1）. Elevated haemoglobin values （EE） are associated with chronic mountain sickness, a condition reflecting the lack of adaptation to HA. According to current data, native men from regions of HA are not adequately adapted to live at such altitudes if they have elevated serum testosterone levels. This seems to be due to an increased conversion of dehydroepiandrosterone sulphate （DH EAS） to testosterone. Men with erythrocytosis at HAs show higher serum androstenedione levels and a lower testosterone/androstenedione ratio than men with EE, suggesting reduced 17beta-hydroxysteroid dehydrogenase （17beta-HSD） activity. Lower 17beta-HSD activity via A4-steroid production in men with erythrocytosis at HA may protect against elevated serum testosterone levels, thus preventing EE. The higher conversion of DHEAS to testosterone in subjects with EE indicates increased 17beta-HSD activity via the A5-pathway. Currently, there are various situations in which people live （human biodiversity） with low or high haemoglobin levels at HA. Antiquity could be an important adaptation component for life at HA, and testosterone seems to participate in this process.
