摘要
目的通过研究慢性自发性荨麻疹(CSU)患者与健康对照组血清脱氢表雄酮硫酸酯(DHEA-S)及总IgE,IL-2,IL-4,IFN-γ水平的差异,探讨CSU患者外周血DHEA-S是否与总IgE、Th1/Th2细胞失衡相关。方法 162例CSU患者为实验组,68例健康人为对照组。应用放射免疫分析法测定血清中DHEA-S水平;采用ELISA法检测外周血总IgE,IL-2,IL-4,IFN-γ水平。采用t检验和直线相关性分析分析各组检测值。结果 CSU组外周血DHEA-S,IL-2,IFN-γ水平明显低于健康对照组,血清总IgE,IL-4水平明显高于健康对照组,差异有统计学意义(P<0.05)。CSU病情分级与DHEA-S水平呈负相关,与总IgE水平呈正相关(r=-0.664,-0.419,P均<0.01),与IL-2,IL-4,IFN-γ水平无明显相关性。CSU组DHEA-S与IL-2,IFN-γ呈显著正相关,与IgE,IL-4呈显著负相关(r=0.409,0.397,-0.319,-0.367,P均<0.001)。结论 CSU患者体内可能存在内分泌免疫系统失衡,外周血DHEA-S水平下降可能与总IgE水平升高及Th1/Th2细胞失衡相关。
Objective To investigate chronic spontaneous urticaria＇s （CSU） dehydroepiandrosterone sulfate relation to total serum IgE, IL-2, IL-4, and IFN-γ in peripheral blood, and further to investigate chronic urticaria＇s dehydroepiandrosterone sulfate relation to total serum IgE and Th1/Th2 out of balance. Methods The serum ehydroepiandrosterone sulfate had been measured by RIA. The expression of total serum IgE, IL-2, IL-4, IFN-γ had been measured by ELISA in 162 patients with CSU, 68 normal controls. All groups of date were analysised by t test and linear correlation. Results The expression of DHEA-S, IL-2, IFN-γ were lower in patients with CSU than in the normal controls （ P 〈 0. 05 ）. The expression of total serum IgE, IL-4 were higher in patients with CSU than in the normal controls （ P 〈 0. 05 ）. The disease classifiction was negative correlation with serum DHEA-S, and it was also positively correlated with the serum total IgE （ r = - 0. 664, -0. 419, all P 〈 0. 01 ） , but the expression of IL-2, IL-4, IFN-γ had no significant correlation with the disease classification. The expression of DHEA-S in CSU patient＇s was positive correlation to the level of IL-2 and IFN-γ,but it was negative correlation to the level of total serum IgE and IL-4 （ r = 0. 409,0. 397, - 0. 319, -0. 367, all P 〈0. 001 ）. Conclusion The neuroendocrine-immune system dysfunction might be related to the CSU. The expression of serum DHEA-S might be relation to total IgE and Th1/Th2 out of balance.
作者
胡月
赵海春
安国芝
陈雷刚
HU Yue ZHAO Hai-chun AN Guo-zhi CHEN Lei-gang(Hebei North University, Zhangjiakou, 075000. China Laboratory First Affiliated Hospital of Hebei North University, Zhangjiakou ,075000, China Dermatology First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2016年第10期1007-1009,1013,共4页
The Chinese Journal of Dermatovenereology
基金
张家口市科技局指令性课题(编号:1311055D-4)
