Exposure to pathogens induces antigen-presenting cells （APC） such as macrophages and dendritic cells （DC） to produce various endogenous mediators, including arachidonic acid （AA）-derived eicosanoids, cytokines, ...Exposure to pathogens induces antigen-presenting cells （APC） such as macrophages and dendritic cells （DC） to produce various endogenous mediators, including arachidonic acid （AA）-derived eicosanoids, cytokines, and nitric oxide （NO）. Many secreted products of activated APC can act by themselves in an autocrine manner and modulate their function. Moreover, the cross-interaction between endogenous bioactive molecules regulates the function of professional APC with important consequences for their ability to activate and sustain immune and inflammatory responses, and to regulate immune homeostasis. Although neglected for many years when compared to their role in cardiovascular homeostasis, cancer and inflammation, the importance of eicosanoids in immunology is becoming more defined. The role of prostaglandin （PG） E2 （PGE2）, one of the best known and most well studied eicosanoids, is of particular interest. It modulates the activities of professional DC by acting on their differentiation, maturation and their ability to secrete cytokines. Uniquely among haematopoietic cytokines, interleukin-10 （IL-10） is a pleiotropic molecule that displays both immunostimulatory and immunoregulatory activities. IL-10 has attached much attention because of its anti-inflammatory properties. It modulates expression of cytokines, soluble mediators and cell surface molecules by cells of myeloid origin, particularly macrophages and DC. We previously reported that PGE2 is a potent inducer of IL-10 in bone marrow-derived DC （BM-DC）, and PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype. BM-DC may be considered as an important model to study complex interactions between endogenous mediators, and autocrine IL-10 plays a pivotal role in the crossregulation of AA-derived lipid mediators, cytokines, and NO, with critical effects on immune and inflammatory responses.展开更多
To improve the simulation accuracy of SIMULINK, a novel inclusive behavior model of an integrator is proposed that introduces the effects of different circuit nonidealities of a switched-capacitor sigma-delta modulato...To improve the simulation accuracy of SIMULINK, a novel inclusive behavior model of an integrator is proposed that introduces the effects of different circuit nonidealities of a switched-capacitor sigma-delta modulator into SIMULIK simulation. The nonlinear DC gain and nonlinear settling process are introduced into the op-amp module. The signaldependent charge injection and nonlinear resistance are introduced into the switch module. In addition, the noise source including flicker and thermal noise is introduced into system as an independent module. The novel model is verified by SIMULINK behavioral simulations. The results are compared with results from circuit level simulation in Cadence SPICE using TSMC 0.35μm mixed signal technology. It shows that the novel model succeeds in introducing the influences of the nonidealities into behavior simulation to more realistically describe the circuit performances and increase the accuracy of SIMULINK simulation.展开更多
针对直流配电网中母线电压控制问题,在双向AC/DC变换器传统双闭环控制器的基础上,设计一种基于扩张状态观测器（extended state observer,ESO）和终端滑模的非线性鲁棒电流前馈控制器,在不需要增加额外电压/电流传感器的情况下实现对系...针对直流配电网中母线电压控制问题,在双向AC/DC变换器传统双闭环控制器的基础上,设计一种基于扩张状态观测器（extended state observer,ESO）和终端滑模的非线性鲁棒电流前馈控制器,在不需要增加额外电压/电流传感器的情况下实现对系统内扰动的快速跟踪,有利于直流配电网中分布式电源与负荷的扩展和即插即用。传统电流前馈控制需要多个电流传感器采集负载电流信息,利用ESO与终端滑模控制理论将电流前馈控制系统转变为以直流母线电压为输入信号的非线性鲁棒电流前馈控制器,有效避免额外传感器的加入,减少装置费用,并且ESO可对系统各状态以及系统模型的不确定性和外部扰动进行实时跟踪,实现对系统中母线电压波动的快速抑制。软件数值仿真结果表明,该控制器表现出良好的控制效果和鲁棒性,对于直流母线电压波动具有很好的稳定效果。展开更多
动态响应特性是双有源桥(Dual Active Bridge,DAB)DC-DC变换器的一个关键指标。为了提高DAB DC-DC变换器在系统发生扰动时的动态响应速度,在单移相控制的基础上,结合直接功率前馈控制(Direct Power Feed-Forward Control,DPFFC)策略,提...动态响应特性是双有源桥(Dual Active Bridge,DAB)DC-DC变换器的一个关键指标。为了提高DAB DC-DC变换器在系统发生扰动时的动态响应速度,在单移相控制的基础上,结合直接功率前馈控制(Direct Power Feed-Forward Control,DPFFC)策略,提出了一种虚拟直接功率控制(Virtual Direct Power Control,VDPC)策略,并建立了VDPC策略下系统发生扰动时的小信号模型,该控制方法无电感、无变压器变比等电路参数参与控制,提高了控制方法的兼容性。最后,在Matlab/Simulink仿真平台上,对虚拟直接功率控制和直接功率前馈控制进行了对比仿真,仿真结果表明:在DAB DC-DC变换器输入电压和负载发生扰动时,虚拟直接功率控制方法具有更快的动态响应性能,且能保证输出电压基本不变。展开更多
文摘Exposure to pathogens induces antigen-presenting cells （APC） such as macrophages and dendritic cells （DC） to produce various endogenous mediators, including arachidonic acid （AA）-derived eicosanoids, cytokines, and nitric oxide （NO）. Many secreted products of activated APC can act by themselves in an autocrine manner and modulate their function. Moreover, the cross-interaction between endogenous bioactive molecules regulates the function of professional APC with important consequences for their ability to activate and sustain immune and inflammatory responses, and to regulate immune homeostasis. Although neglected for many years when compared to their role in cardiovascular homeostasis, cancer and inflammation, the importance of eicosanoids in immunology is becoming more defined. The role of prostaglandin （PG） E2 （PGE2）, one of the best known and most well studied eicosanoids, is of particular interest. It modulates the activities of professional DC by acting on their differentiation, maturation and their ability to secrete cytokines. Uniquely among haematopoietic cytokines, interleukin-10 （IL-10） is a pleiotropic molecule that displays both immunostimulatory and immunoregulatory activities. IL-10 has attached much attention because of its anti-inflammatory properties. It modulates expression of cytokines, soluble mediators and cell surface molecules by cells of myeloid origin, particularly macrophages and DC. We previously reported that PGE2 is a potent inducer of IL-10 in bone marrow-derived DC （BM-DC）, and PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype. BM-DC may be considered as an important model to study complex interactions between endogenous mediators, and autocrine IL-10 plays a pivotal role in the crossregulation of AA-derived lipid mediators, cytokines, and NO, with critical effects on immune and inflammatory responses.
基金the National Natural Science Foundation of China(No.90707002)~~
文摘To improve the simulation accuracy of SIMULINK, a novel inclusive behavior model of an integrator is proposed that introduces the effects of different circuit nonidealities of a switched-capacitor sigma-delta modulator into SIMULIK simulation. The nonlinear DC gain and nonlinear settling process are introduced into the op-amp module. The signaldependent charge injection and nonlinear resistance are introduced into the switch module. In addition, the noise source including flicker and thermal noise is introduced into system as an independent module. The novel model is verified by SIMULINK behavioral simulations. The results are compared with results from circuit level simulation in Cadence SPICE using TSMC 0.35μm mixed signal technology. It shows that the novel model succeeds in introducing the influences of the nonidealities into behavior simulation to more realistically describe the circuit performances and increase the accuracy of SIMULINK simulation.
文摘针对直流配电网中母线电压控制问题,在双向AC/DC变换器传统双闭环控制器的基础上,设计一种基于扩张状态观测器（extended state observer,ESO）和终端滑模的非线性鲁棒电流前馈控制器,在不需要增加额外电压/电流传感器的情况下实现对系统内扰动的快速跟踪,有利于直流配电网中分布式电源与负荷的扩展和即插即用。传统电流前馈控制需要多个电流传感器采集负载电流信息,利用ESO与终端滑模控制理论将电流前馈控制系统转变为以直流母线电压为输入信号的非线性鲁棒电流前馈控制器,有效避免额外传感器的加入,减少装置费用,并且ESO可对系统各状态以及系统模型的不确定性和外部扰动进行实时跟踪,实现对系统中母线电压波动的快速抑制。软件数值仿真结果表明,该控制器表现出良好的控制效果和鲁棒性,对于直流母线电压波动具有很好的稳定效果。
文摘动态响应特性是双有源桥(Dual Active Bridge,DAB)DC-DC变换器的一个关键指标。为了提高DAB DC-DC变换器在系统发生扰动时的动态响应速度,在单移相控制的基础上,结合直接功率前馈控制(Direct Power Feed-Forward Control,DPFFC)策略,提出了一种虚拟直接功率控制(Virtual Direct Power Control,VDPC)策略,并建立了VDPC策略下系统发生扰动时的小信号模型,该控制方法无电感、无变压器变比等电路参数参与控制,提高了控制方法的兼容性。最后,在Matlab/Simulink仿真平台上,对虚拟直接功率控制和直接功率前馈控制进行了对比仿真,仿真结果表明:在DAB DC-DC变换器输入电压和负载发生扰动时,虚拟直接功率控制方法具有更快的动态响应性能,且能保证输出电压基本不变。
