【目的】评价不同延迟断脐时间对预防足月儿贫血的效果及安全性，为预防足月儿贫血提供相关理论依据。【方法】检索PubMed、EMBASE、维普资讯和中国知网等关于延迟断脐研究的随机对照试验文献。依据文献纳入和排除标准对文献进行筛选和...【目的】评价不同延迟断脐时间对预防足月儿贫血的效果及安全性，为预防足月儿贫血提供相关理论依据。【方法】检索PubMed、EMBASE、维普资讯和中国知网等关于延迟断脐研究的随机对照试验文献。依据文献纳入和排除标准对文献进行筛选和质量评价，以RevMan5．0．18软件进行定量合并分析。【结果】共纳入7篇文献，文献质量为A级2篇，B级5篇。Meta分析显示：出生后〉30s且〈2min断脐（DCC1）与早期断脐（ECC，出生后≤30s）相比，两组间贫血发病风险（OR=0．43，95％ CI 0．15～1．23）、出生后第一天红细胞增多症发病风险（OR=1．71，95％ CI 0．52～5．65）和出生后病理性黄疽发病风险（OR=1．15，95％ CI 0．66～2．01）均无统计学差异；而出生后≥2min、脐血管停止搏动或胎盘排出后断脐（DCC2），贫血发病率较ECC组低（OR=0．22，95％ CI 0．11～0．43），尽管可能增加出生后第1d红细胞增多症的发病风险（OR=2．08，95％ CI 1．01～4．28），但两组间病理性黄疸发病风险无明显统计学差异（OR=0．69，95％CI 0．30～1．55）。【结论】延迟2min以上结扎脐带是预防足月儿贫血的有效手段，但有可能增加出生后红细胞增多症发病风险；应开展多中心大样本临床随机对照试验进一步证实。展开更多
<strong>OBJECTIVE</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-...<strong>OBJECTIVE</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><strong>:</strong></span></span></span></span><span><span><span><b><span style="font-family:""> </span></b></span></span></span><span><span><span><span style="font-family:""><span style="font-family:Verdana;">To compare maternal preoperative and postoperative hemoglobin variation after cord clamping. </span><b><span style="font-family:Verdana;">METHODS: </span></b><span style="font-family:Verdana;">Randomized clinical trial performed in Porto Alegre, RS from January to December 2012. It was included 356 women with habitual risk gestations. In the immediate cord clamping group</span></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span></span><span><span><span><span style="font-family:""><span style="font-family:Verdana;"> the umbilical cord section was realized between 0 and 60 s (group 1) while in the delayed cord clamping group it was realized >60 s (group 2). </span><b><span style="font-family:Verdana;">RESULTS:</span></b><span style="font-family:Verdana;"> The mean (±standard deviation [SD]) preoperative hemoglobin was 12.13 ± 1.06 in the group 1 and 12.13 ± 1.11 in the group 2. The mean (±SD) postoperative day 2 hemoglobin level was 10.19 ± 1.46 in the group 1 and 10.24 ± 1.42 in the group 2. </span><b><span style="font-family:Verdana;">CONCLUSIONS: </span></b><span style="font-family:Verdana;">Delayed umbilical cord clamping resulted in a similar maternal hemoglobin level reduction at postoperative day 2.</span></span></span></span></span>展开更多
Autism spectrum disorder(ASD)is a high genetic heterogeneity neurodevelopmental disorder characterized by social,communicative,and behavioral deficits.However,there are very few studies thus far addressing risk factor...Autism spectrum disorder(ASD)is a high genetic heterogeneity neurodevelopmental disorder characterized by social,communicative,and behavioral deficits.However,there are very few studies thus far addressing risk factors for ASD in China children.This case-control study aims to investigate whether various risk factors especially cesarean section,epidural analgesia during labor,immediate cord clamping at birth were associated with the risk of having an offspring with ASD.There were 50 children with ASD(age 34.76±7.78 months)and 150 normal children(age 33.76±6.73 months)enrolled in this study.The risk of developing ASD in these children included cesarean section(RR=3.512,95%confidence interval(CI)=1.162–10.620),anesthesia for pain relief(RR=3.387,95%CI=1.160–9.891),early cord clamping(RR=19.062,95%CI=3.894–93.0304),gender of boy(RR=3.530,95%CI=1.223–10.188).Further research is needed to determine whether such factors have a causal link to ASD.展开更多
文摘【目的】评价不同延迟断脐时间对预防足月儿贫血的效果及安全性，为预防足月儿贫血提供相关理论依据。【方法】检索PubMed、EMBASE、维普资讯和中国知网等关于延迟断脐研究的随机对照试验文献。依据文献纳入和排除标准对文献进行筛选和质量评价，以RevMan5．0．18软件进行定量合并分析。【结果】共纳入7篇文献，文献质量为A级2篇，B级5篇。Meta分析显示：出生后〉30s且〈2min断脐（DCC1）与早期断脐（ECC，出生后≤30s）相比，两组间贫血发病风险（OR=0．43，95％ CI 0．15～1．23）、出生后第一天红细胞增多症发病风险（OR=1．71，95％ CI 0．52～5．65）和出生后病理性黄疽发病风险（OR=1．15，95％ CI 0．66～2．01）均无统计学差异；而出生后≥2min、脐血管停止搏动或胎盘排出后断脐（DCC2），贫血发病率较ECC组低（OR=0．22，95％ CI 0．11～0．43），尽管可能增加出生后第1d红细胞增多症的发病风险（OR=2．08，95％ CI 1．01～4．28），但两组间病理性黄疸发病风险无明显统计学差异（OR=0．69，95％CI 0．30～1．55）。【结论】延迟2min以上结扎脐带是预防足月儿贫血的有效手段，但有可能增加出生后红细胞增多症发病风险；应开展多中心大样本临床随机对照试验进一步证实。
文摘<strong>OBJECTIVE</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><strong>:</strong></span></span></span></span><span><span><span><b><span style="font-family:""> </span></b></span></span></span><span><span><span><span style="font-family:""><span style="font-family:Verdana;">To compare maternal preoperative and postoperative hemoglobin variation after cord clamping. </span><b><span style="font-family:Verdana;">METHODS: </span></b><span style="font-family:Verdana;">Randomized clinical trial performed in Porto Alegre, RS from January to December 2012. It was included 356 women with habitual risk gestations. In the immediate cord clamping group</span></span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span></span><span><span><span><span style="font-family:""><span style="font-family:Verdana;"> the umbilical cord section was realized between 0 and 60 s (group 1) while in the delayed cord clamping group it was realized >60 s (group 2). </span><b><span style="font-family:Verdana;">RESULTS:</span></b><span style="font-family:Verdana;"> The mean (±standard deviation [SD]) preoperative hemoglobin was 12.13 ± 1.06 in the group 1 and 12.13 ± 1.11 in the group 2. The mean (±SD) postoperative day 2 hemoglobin level was 10.19 ± 1.46 in the group 1 and 10.24 ± 1.42 in the group 2. </span><b><span style="font-family:Verdana;">CONCLUSIONS: </span></b><span style="font-family:Verdana;">Delayed umbilical cord clamping resulted in a similar maternal hemoglobin level reduction at postoperative day 2.</span></span></span></span></span>
文摘Autism spectrum disorder(ASD)is a high genetic heterogeneity neurodevelopmental disorder characterized by social,communicative,and behavioral deficits.However,there are very few studies thus far addressing risk factors for ASD in China children.This case-control study aims to investigate whether various risk factors especially cesarean section,epidural analgesia during labor,immediate cord clamping at birth were associated with the risk of having an offspring with ASD.There were 50 children with ASD(age 34.76±7.78 months)and 150 normal children(age 33.76±6.73 months)enrolled in this study.The risk of developing ASD in these children included cesarean section(RR=3.512,95%confidence interval(CI)=1.162–10.620),anesthesia for pain relief(RR=3.387,95%CI=1.160–9.891),early cord clamping(RR=19.062,95%CI=3.894–93.0304),gender of boy(RR=3.530,95%CI=1.223–10.188).Further research is needed to determine whether such factors have a causal link to ASD.
