Based on the binding mode for hydrouracil in photosystem II (PS II) Dl protein, a general method for the solid phase combinatorial synthesis of hydrouracil library was developed. The acryloyl chloride or acid were cou...Based on the binding mode for hydrouracil in photosystem II (PS II) Dl protein, a general method for the solid phase combinatorial synthesis of hydrouracil library was developed. The acryloyl chloride or acid were coupled to Wang resin1 to afford the acryloyl ester2. Resin bound ester2 reacted with various primary amines to give secondary amines3, which were converted to the resin bound ureas4 by treatment with isocyanates. Preparation of the hydrouracils5 was achieved by the acidic cyclization-cleavage from the resin. For characterization purposes,8 hydrouracil analogues were synthesized in parallel, following which a small library of9 hydrouracil derivatives was prepared after cleavage from Wang resin. All the9 bydrouracil derivatives desired were identified by GCMS.展开更多
Polyamine-based scavenger resins containing 2, 3 and 4 nitrogen atoms have been prepared and their comparative efficacy to scavenge appropriate electrophilic chemicals (acids, acid chlorides, isocyanates and aldehydes...Polyamine-based scavenger resins containing 2, 3 and 4 nitrogen atoms have been prepared and their comparative efficacy to scavenge appropriate electrophilic chemicals (acids, acid chlorides, isocyanates and aldehydes) from solutions has been studied. As expected, the scavenging efficiency is directly proportional to the number of nucleophic nitrogens present on the resin. The results have been compared with the performance of the popular scavenger resin, namely, tris(2-aminoethyl)amine resin, to conclude that the low-cost polyamine resins now prepared can be conveniently used as effectively as the expensive commercial product.展开更多
文摘Based on the binding mode for hydrouracil in photosystem II (PS II) Dl protein, a general method for the solid phase combinatorial synthesis of hydrouracil library was developed. The acryloyl chloride or acid were coupled to Wang resin1 to afford the acryloyl ester2. Resin bound ester2 reacted with various primary amines to give secondary amines3, which were converted to the resin bound ureas4 by treatment with isocyanates. Preparation of the hydrouracils5 was achieved by the acidic cyclization-cleavage from the resin. For characterization purposes,8 hydrouracil analogues were synthesized in parallel, following which a small library of9 hydrouracil derivatives was prepared after cleavage from Wang resin. All the9 bydrouracil derivatives desired were identified by GCMS.
文摘Polyamine-based scavenger resins containing 2, 3 and 4 nitrogen atoms have been prepared and their comparative efficacy to scavenge appropriate electrophilic chemicals (acids, acid chlorides, isocyanates and aldehydes) from solutions has been studied. As expected, the scavenging efficiency is directly proportional to the number of nucleophic nitrogens present on the resin. The results have been compared with the performance of the popular scavenger resin, namely, tris(2-aminoethyl)amine resin, to conclude that the low-cost polyamine resins now prepared can be conveniently used as effectively as the expensive commercial product.
