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新型菊酯类化合物的组合合成及杀菌活性 被引量:1

Screening Synthesis of Pyrethroid for Fungicide from Combinatorial Library
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摘要 以菊酯为骨架 ,采用组合平行法 ,设计合成了新型含氮杂环的菊酯类化合物库。经高分辨质谱和GC鉴定 ,合成成功率为 10 0 %。对化合物库进行了体外和体内的杀菌活性筛选。结果表明 ,在体外 9种活性的ED50 的测试中 ,AD7在棉花立枯病菌测试中ED50 <1 0× 10 -7%。同时还有多个化合物在不同的测试中显示ED50 <1 0× 10 -6%。而在 6种体内活性测试中 ,大多数化合物对蕃茄晚疫霉菌和蕃茄底腐霉菌表现出了较好的抑制活性。 A new nitrogen-containing heterocyclic pyrethroid library was designed and constructed using combinatorial parallel synthesis. To evaluate the library synthesis, some sampled compounds in the library were identified by HRMS and their purities were estimated by GC analysis. All compounds in the library were screened by fungicidal activity tests in vitro and in vivo. The results showed that, AD7 has ED 50<1.0×10 -7% against RHIZSO in 9 kinds of ED 50 tests in vitro, meanwhile, some compounds have ED 50<1.0×10 -6% against the test targets. While the library was tested in vivo, majority of the fungicidal activities of the compounds were focused on PHYTIN and ALTESO.
出处 《应用化学》 CAS CSCD 北大核心 2004年第3期243-246,共4页 Chinese Journal of Applied Chemistry
基金 国家重点基础研究发展规划项目 (2 0 0 3CB114 40 0 )资助
关键词 菊酯化合物库 组合合成 杀菌活性 pyrethroid library,combinatorial synthesis,fungicide
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