OBJECTIVE：This meta-analysis was performed to systematically assess the efficacy and safety of the Chinese herbal medicine Huangqi Guizhi Wuwu Decoction（HGWWD） for treating diabetic peripheral neuropathy.DATA SOUR...OBJECTIVE：This meta-analysis was performed to systematically assess the efficacy and safety of the Chinese herbal medicine Huangqi Guizhi Wuwu Decoction（HGWWD） for treating diabetic peripheral neuropathy.DATA SOURCES：Six electronic databases,including the Cochrane Library,MEDLINE database,Chinese Biomedical Database,Chinese National Knowledge Infrastructure Database,Chinese Science and Technique Journals Database,and the Wanfang Database,were search ed on the internet for randomized controlled trials published up until 1 December 2015.The search terms included ＂Chinese herbal medicine＂,＂diabetic peripheral neuropathy＂ and ＂randomized controlled trials＂ in Chinese and in English.DATA SELECTION：We included randomized controlled trials using HGWWD/modified HGWWD for the treatment group,without restriction for the control group.We assessed literature quality in accordance with the Cochrane Review Handbook.A random or a fixed effects model was used to analyze outcomes using Rev Man 5.2 software.OUTCOME MEASURES：The primary outcomes were changes in symptoms and nerve conduction velocities.The secondary outcomeswere fasting blood glucose and hemorheological indexes.RESULTS：Sixteen randomized controlled trials,with a total of 1,173 patients,were included.Meta-analysis revealed that the efficacy of HGWWD for diabetic peripheral neuropathy was significantly superior compared with the control treatment（i.e.,control group）（risk ratio = 0.36,95% confidence interval（CI）：0.29–0.46,Z =8.33,P 〈 0.00001） Compared with the control group,there was an increase in median motor nerve conduction velocity（mean difference（MD） = 3.46,95%CI：1.88–5.04,Z = 4.30,P 〈 0.01） and median sensory nerve conduction velocity（MD = 3.30,95%CI：2.04–4.56,Z = 5.14,P 〈 0.01）.There was also an increase in peroneal motor nerve conduction velocity（MD = 3.22,95%CI：2.45–3.98,Z = 8.21,P 〈 0.01） and peroneal sensory nerve conduction velocity（MD = 3.05,95%CI：2.01–4.09,Z = 5.75,P 〈 展开更多
目的:探讨中药熏洗配合口服中药治疗产后痔疮的临床疗效。方法:选择2013年1月—2014年12月在医院诊断治疗的产后痔疮患者88例,随机分为对照组和观察组各44例,观察组患者使用中药熏洗法,同时配合口服中药,每日2次,7天为1疗程。对照组患者...目的:探讨中药熏洗配合口服中药治疗产后痔疮的临床疗效。方法:选择2013年1月—2014年12月在医院诊断治疗的产后痔疮患者88例,随机分为对照组和观察组各44例,观察组患者使用中药熏洗法,同时配合口服中药,每日2次,7天为1疗程。对照组患者用1∶5000高锰酸钾溶液1000 m L以上述同样的方法熏洗坐浴治疗,每日2次,7天为1个疗程。两组患者均给予相应对症治疗,如通便、局部理疗等,如有感染局部涂抹抗感染药膏。观察两组患者临床疗效,治疗前后疼痛评分的变化,治疗后症状消失时间。结果:观察组总有效率95.45%,对照组总有效率为79.54%,观察组显著优于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者疼痛评分均显著改善,且观察组改善情况显著优于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者疼痛消失时间、水肿异常消失时间、脱出物消失时间均显著短于对照组,差异具有统计学意义(P<0.05)。两组不良反应均较轻,发生率差异不具有统计学意义(P>0.05)。结论:中药熏洗配合口服中药对产后痔疮患者进行治疗,临床疗效显著,可以有效改善患者项临床症状及体征,且无明显不良反应发生,值得临床推广应用。展开更多
基金supported by a grant from the National Basic Research Program of China(973 Program),No.2010CB530600Institutes Project from Guang’anmen Hospital of China Academy of Chinese Medical Sciences,No.2011261
文摘OBJECTIVE：This meta-analysis was performed to systematically assess the efficacy and safety of the Chinese herbal medicine Huangqi Guizhi Wuwu Decoction（HGWWD） for treating diabetic peripheral neuropathy.DATA SOURCES：Six electronic databases,including the Cochrane Library,MEDLINE database,Chinese Biomedical Database,Chinese National Knowledge Infrastructure Database,Chinese Science and Technique Journals Database,and the Wanfang Database,were search ed on the internet for randomized controlled trials published up until 1 December 2015.The search terms included ＂Chinese herbal medicine＂,＂diabetic peripheral neuropathy＂ and ＂randomized controlled trials＂ in Chinese and in English.DATA SELECTION：We included randomized controlled trials using HGWWD/modified HGWWD for the treatment group,without restriction for the control group.We assessed literature quality in accordance with the Cochrane Review Handbook.A random or a fixed effects model was used to analyze outcomes using Rev Man 5.2 software.OUTCOME MEASURES：The primary outcomes were changes in symptoms and nerve conduction velocities.The secondary outcomeswere fasting blood glucose and hemorheological indexes.RESULTS：Sixteen randomized controlled trials,with a total of 1,173 patients,were included.Meta-analysis revealed that the efficacy of HGWWD for diabetic peripheral neuropathy was significantly superior compared with the control treatment（i.e.,control group）（risk ratio = 0.36,95% confidence interval（CI）：0.29–0.46,Z =8.33,P 〈 0.00001） Compared with the control group,there was an increase in median motor nerve conduction velocity（mean difference（MD） = 3.46,95%CI：1.88–5.04,Z = 4.30,P 〈 0.01） and median sensory nerve conduction velocity（MD = 3.30,95%CI：2.04–4.56,Z = 5.14,P 〈 0.01）.There was also an increase in peroneal motor nerve conduction velocity（MD = 3.22,95%CI：2.45–3.98,Z = 8.21,P 〈 0.01） and peroneal sensory nerve conduction velocity（MD = 3.05,95%CI：2.01–4.09,Z = 5.75,P 〈
文摘目的:探讨中药熏洗配合口服中药治疗产后痔疮的临床疗效。方法:选择2013年1月—2014年12月在医院诊断治疗的产后痔疮患者88例,随机分为对照组和观察组各44例,观察组患者使用中药熏洗法,同时配合口服中药,每日2次,7天为1疗程。对照组患者用1∶5000高锰酸钾溶液1000 m L以上述同样的方法熏洗坐浴治疗,每日2次,7天为1个疗程。两组患者均给予相应对症治疗,如通便、局部理疗等,如有感染局部涂抹抗感染药膏。观察两组患者临床疗效,治疗前后疼痛评分的变化,治疗后症状消失时间。结果:观察组总有效率95.45%,对照组总有效率为79.54%,观察组显著优于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者疼痛评分均显著改善,且观察组改善情况显著优于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者疼痛消失时间、水肿异常消失时间、脱出物消失时间均显著短于对照组,差异具有统计学意义(P<0.05)。两组不良反应均较轻,发生率差异不具有统计学意义(P>0.05)。结论:中药熏洗配合口服中药对产后痔疮患者进行治疗,临床疗效显著,可以有效改善患者项临床症状及体征,且无明显不良反应发生,值得临床推广应用。
